Male breast cancer: is the scenario changing

Contractor, Kaiyumars; Kaur, Kanchan; Rodrigues, Gabriel; Kulkarni, Deepak; Singhal, Hemant

doi:10.1186/1477-7819-6-58

Cited by 109 publications

(122 citation statements)

References 129 publications

(121 reference statements)

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…In our study five year survival of men with breast cancer in relation to stage of the disease is much lower and amounts to 100% for T1 stage of the disease, T2 stage 87%, T3 stage 38%, while for T4 stage 0%. In numerous studies the clinical stage of disease is identified as a significant independent prognostic factor for survival of men with breast cancer (Vaizey et al, 1999), and even as a separate risk factor independent from tumor size or lymph node metastasis (Contractor et al, 2008;Schaub et al, 2008;Gomes-Raposo et al, 2010). In our study, a lower initial disease stage, a lower tumor grade, application of adjuvant hormone therapy and no relaps occurrence were independent predictors of a favorable outcome of breast cancer in males.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multivariate Analysis of Prognostic Factors in Male Breast Cancer in Serbia

Šipetić-Grujičić

Murtezani²,

Z³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The aim of this study was to analyze the demographic and clinical characteristics of male breast cancer patients in Serbia, and furthermore to determine overall survival and predictive factors for prognosis. Materials and Methods: In the period of 1996-2006 histopathological diagnosis of breast cancer was made in 84 males at the Institute for Oncology and Radiology of Serbia. For statistical analyses the Kaplan-Meier method, long-rank test and Cox proportional hazards regression model were used. Results: The mean age at diagnosis with breast cancer was 64.3±10.5 years with a range from 35-84 years. Nearly 80% of the tumors showed ductal histology. About 44% had early tumor stages (I and II) whereas 46.4% and 9.5% of the male exhibitied stages III and IV, respectively. Only 7.1% of male patients were grade one. One-fifth of all patients had tumors measuring ≤2 cm, and 14.3% larger than 5 cm. Lymph node metastasis was recorded in 40.4% patients and 47% relapse. Estrogen and progesterone receptor expression was positive in 66.7% and 58.3%, respectively. Among 14.3% of individuals tumor was HER2 positive. About two-thirds of all male patients had radical mastectomy (66.7%). Adjuvant hormonal (tamoxifene), systematic chemotherapy (CMF or FAC) and adjuvant radiotherapy were given to 59.5%, 35.7% and 29.8% patients respectively. Overall survival rates at five and ten years for male breast cancer were 55.0% and 43.9%, respectively. According to the multivariate Cox regression predictive model, a lower initial disease stage, a lower tumor grade, application of adjuvant hormone therapy and no relapse occurrence were significant independent predictors for good overall survival. Conclusions: Results of the treatment would be better if disease is discovered earlier and therefore health education and screening are an imperative in solving this problem.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The etiology of breast cancer in male has been hardly studied, because the disease is very rare (Weiss et al, 2005;Contractor et al, 2008;Schaub et al, 2008). However the incidence of breast cancer in male's population is on the constant increase (Weiss et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Multivariate Analysis of Prognostic Factors in Male Breast Cancer in Serbia

Šipetić-Grujičić

Murtezani²,

Z³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…As summarized in [1], a higher positivity rate of estrogen and progesterone receptors (ER and PgR) in MBC respect to FBC is well established. However, Munoz de Toro et al [5] remarkably found that in MBC proliferation rate was higher in ER+/PgR+ compared to ER-/PgR-tumors, an opposite finding respect to FBC which strongly support the hypothesis that these receptors may play a different role in males compared to women.…”

Section: Introductionmentioning

confidence: 99%

“…However, Munoz de Toro et al [5] remarkably found that in MBC proliferation rate was higher in ER+/PgR+ compared to ER-/PgR-tumors, an opposite finding respect to FBC which strongly support the hypothesis that these receptors may play a different role in males compared to women. Controversial data were reported for AR positivity as well as for ERBB2 amplification rate, with positivity rates ranging from 0 to 95% among different studies [1][2][6][7]. Furthermore, an immunohistochemical analysis of ER, AR and functionally related proteins indicates a reduced functionality of ER but a significant role for AR in MBC [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gene expression analysis reveals a different transcriptomic landscape in female and male breast cancer

Callari

Cappelletti

Cecco

et al. 2010

Breast Cancer Res Treat

View full text Add to dashboard Cite

Results -Almost 1000 genes were found differentially expressed (FDR<1%) between female and male patients and biological interpretation highlighted a gender associated modulation of key biological processes ranging from energy metabolism to regulation of translation and matrix remodeling as well as immune system recruitment. Moreover, an analysis of genes correlated to steroid receptors and ERBB2 suggested a prominent role for the androgen receptor in MBC with a minor relevance for progesterone receptor and ERBB2, although, similarly to FBC, a genomic amplification could be observed.Conclusions -Our findings support the idea that breast cancer is a quite different disease in male and female patients and the underlying gender related biological differences are likely to have clinical implications connected with different susceptibility to treatment.3

show abstract

Oh, to Live in an Age When Men Had Breasts . . .

Wright¹

2009

JAMA

View full text Add to dashboard Cite

Male breast cancer: is the scenario changing

Cited by 109 publications

References 129 publications

Multivariate Analysis of Prognostic Factors in Male Breast Cancer in Serbia

Multivariate Analysis of Prognostic Factors in Male Breast Cancer in Serbia

Gene expression analysis reveals a different transcriptomic landscape in female and male breast cancer

Oh, to Live in an Age When Men Had Breasts . . .

Contact Info

Product

Resources

About