Breakthrough innovations in the U.S. biotechnology industry: the effects of technological space and geographic origin

Phene, Anupama; Fladmoe-Lindquist, Karin; Marsh, Laurence A.

doi:10.1002/smj.522

Cited by 498 publications

(449 citation statements)

References 71 publications

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“…More generally, our empirical results find strong support for the role that economic incentives, bounded rationality, heterogeneity, and communication play in determining successful alliance outcomes, which will hopefully generate new interest and empirical inquiry concerning factors that relate to strategic alliance success. Indeed, the theoretical logic and empirical results presented here can be applied to a large number of strategic contexts including buyer-supplier arrangements, joint ventures, franchising, internal corporate ventures, networks, R&D consortia, technology transfer agreements, and intraorganizational teams (Lerner and Merges, 1998;Phene, Fladmoe-Lindquest, and Marsh, 2006;Roethaermel and Deeds, 2004;Reuer and Ragozzino, 2006;Santoro and McGill, 2005).…”

Section: Discussionmentioning

confidence: 99%

The role of incentives and communication in strategic alliances: an experimental investigation

Agarwal

Croson

Mahoney

2009

Strategic Management Journal

147

120

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Section: Discussionmentioning

confidence: 99%

The role of incentives and communication in strategic alliances: an experimental investigation

Agarwal

Croson

Mahoney

2009

Strategic Management Journal

147

120

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“…However, if successful, technologies coming through this phase and moving to the growth stage have more opportunities to become radical innovations, hence breaking existing technological paradigms [64], shifting towards new trajectories, and representing the basis on which further innovations are built. Therefore, novel patented innovations may represent rare, valuable, and inimitable sources of competitive advantage for firms [67], allowing business growth and new business development [13]. Such an advantage mainly derives from the benefits associated with learning economies [68], causal ambiguity [69], switching costs [70], consumer learning, and reputation advantages [71].…”

Section: Noveltymentioning

confidence: 99%

“…BioScan is one of the most recognized biotechnology industry reporting services [13]. We searched for patents firms filed under the US patent system during the observation period 1976-2003 by querying the USPTO database.…”

Section: Research Setting and Sample Datamentioning

confidence: 99%

Determinants of patent citations in biotechnology: An analysis of patent influence across the industrial and organizational boundaries

Petruzzelli

Rotolo

Albino

2015

Technological Forecasting and Social Change

148

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The present paper extends the literature investigating key drivers leading certain patents to exert a stronger influence on the subsequent technological developments (inventions) than other ones. We investigated six key determinants, as (i) the use of scientific knowledge, (ii) the breadth of the technological base, (iii) the existence of collaboration in patent development, (iv) the number of claims, (v) the scope, and (vi) the novelty, and how the effect of these determinants varies when patent influence-as measured by the number of forward citations the patent received-is distinguished as within and across the industrial and organizational boundaries. We conducted an empirical analysis on a sample of 5,671 patents granted to 293 US biotechnology firms from 1976 to 2003. Results reveal that the contribution of the determinants to patent influence differs across the domains that are identified by the industrial and organizational boundaries. Findings, for example, show that the use of scientific knowledge negatively affects patent influence outside the biotechnology industry, while it positively contributes to make a patent more relevant for the assignee's subsequent technological developments. In addition, the broader the scope of a patent the higher the number of citations the patent receives from subsequent non-biotechnology patents.This relationship is inverted U-shaped when considering the influence of a patent on inventions granted to other organizations than the patent's assignee. Finally, the novelty of a patent is inverted-U related with the influence the patent exerts on the subsequent inventions granted across the industrial and organizational boundaries.

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“…Empirical results support this argument. Using the example of the biotechnology industry in the U.S., PHENE et al (2006) determined that technological distances are more easily bridged between companies in the U.S. than with partners abroad.…”

Section: Localised Learning and Cluster Dynamicsmentioning

confidence: 99%

Cluster Life Cycles - Dimensions and Rationales of Cluster Development

Menzel

Fornahl

Planck³

2007

SSRN Journal

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Standard-Nutzungsbedingungen:Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden.Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen.Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Terms of use: Documents in AbstractWe present a model that explains how a cluster moves through a life cycle and why this movement differs from the industry life cycle. The model is based on three key processes: the changing heterogeneity in the cluster describes the movement of the cluster through the life cycle; the geographical absorptive capacity enables clustered companies to take advantage of a larger diversity of knowledge and the stronger convergence of clustered companies compared to non-clustered companies results in a reduction of heterogeneity. We apply these processes to four stages of the cluster life cycle: emergence, growth, sustainment and decline.JEL-classification: R11, O30, L25

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Breakthrough innovations in the U.S. biotechnology industry: the effects of technological space and geographic origin

Cited by 498 publications

References 71 publications

The role of incentives and communication in strategic alliances: an experimental investigation

The role of incentives and communication in strategic alliances: an experimental investigation

Determinants of patent citations in biotechnology: An analysis of patent influence across the industrial and organizational boundaries

Cluster Life Cycles - Dimensions and Rationales of Cluster Development

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