Brazilian Tabernaemontana genus: Indole alkaloids and phytochemical activities

Marinho, Flávio; Simões, André Olmos; Barcellos, Thiago; Moura, Sidnei

doi:10.1016/j.fitote.2016.09.002

Cited by 35 publications

(28 citation statements)

References 56 publications

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“…Although phenolics are widely identified in species belonging to the Apocynaceae family [ 43 , 44 ], most of its genera is known to have monoterpene indole alkaloids as the major class of secondary metabolites [ 45 , 46 , 47 , 48 ]. Hancornia seems to be an exception; no alkaloids have been described for this species.…”

Section: Discussionmentioning

confidence: 99%

Identification of Phenolic Compounds from Hancornia speciosa (Apocynaceae) Leaves by UHPLC Orbitrap-HRMS

Bastos¹,

Dias²,

Nascimento³

et al. 2017

Molecules

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Apocynaceae is a botanical family distributed mainly in tropical and subtropical regions of the world. In Brazil, they comprise about 90 genera and 850 species, inhabiting various types of vegetation. Within this large botanical family, the genus Hancornia is considered monotypic, with its only species Hancornia speciosa Gomes. Antihypertensive, antidiabetic, and antiviral activities are described for this species. Despite having been the target of some studies, knowledge of its chemical composition is still limited. In this study, the phenolics of H. speciosa leaves were analyzed using ultra-high performance liquid chromatography (UHPLC) coupled to Orbitrap high-resolution mass spectrometry (HRMS). As a result, 14 compounds were identified viz. protocatechuic acid, catechin, and quercetin, and another 14 were putatively identified viz. B- and C-type procyanidins, while just one compound remained unknown. From the identified compounds, 17 are reported for the first time viz. coumaroylquinic acid isomers and eriodyctiol. The results show that Hancornia speciosa can serve as source of valuable phenolics.

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Section: Discussionmentioning

confidence: 99%

Identification of Phenolic Compounds from Hancornia speciosa (Apocynaceae) Leaves by UHPLC Orbitrap-HRMS

Bastos¹,

Dias²,

Nascimento³

et al. 2017

Molecules

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“…We next examined the in vitro toxicity of extracts against chloroquine-resistant P. falciparum eugenifolius, A. subulatum, and C. aeruginosa had good activities for P. falciparum K1 (Rahman, 2012). Members of the genus Leuconotis Jack (1823) and Tabernaemontana L. 1753are known for antiplasmodial activity (Nugroho et al, 2012;Marinho et al, 2016). To the best of our knowledge, good activities from these 6 medicinal plants are being reported for the first time.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Anti-infective activities of 11 plants species used in traditional medicine in Malaysia

Azman

Hossan

Nissapatorn

et al. 2018

Experimental Parasitology

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Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically important plant species in Malaysia. Chloroform extracts were tested for their toxicity against MRC-5 cells and Leishmania donovani by MTT, and chloroquine-resistant Plasmodium falciparum K1 strain by Histidine-Rich Protein II ELISA assays. None of the extract tested was cytotoxic to MRC-5 cells. Extracts of Uvaria grandiflora, Chilocarpus costatus, Tabernaemontana peduncularis, and Leuconotis eugenifolius had good activities against L. donovani with IC 50 < 50 µg/mL. Extracts of U. grandiflora, C. costatus, T. peduncularis, L. eugenifolius, A. subulatum, and C. aeruginosa had good activities against P. falciparum K1 with IC 50 < 10 µg/mL. Pinoresinol isolated from C. costatus was inactive against L. donovani and P. falciparum. C. costatus extract and pinoresinol increased the sensitivity of Staphylococcus epidermidis to cefotaxime. Pinoresinol demonstrated moderate activity against influenza virus (IC 50 = 30.4 ± 11 µg/mL) and was active against Coxsackie virus B3 (IC 50 = 7.1 ± 3.0 µg/mL). β-Amyrin from L. eugenifolius inhibited L. donovani with IC 50 value of 15.4 ± 0.01 µM. Furanodienone from C. aeruginosa inhibited L. donovani and P. falciparum K1 with IC 50 value of 39.5 ± 0.2 and 17.0 ± 0.05 µM, respectively. Furanodienone also inhibited the replication of influenza and Coxsackie virus B3 with IC 50 value of 4.0 ± 0.5 and 7.2 ± 1.4 µg/mL (Ribavirin: IC 50 : 15.6 ± 2.0 µg/mL), respectively. Our study provides evidence that medicinal plants in Malaysia have potentials as a source of chemotypes for the development of antiinfective leads.

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“…No Brasil são reconhecidas 30 espécies do gênero, sendo nove endêmicas (KOCH et al, 2015). A espécie Tabernaemontana divaricata, conhecida vulgarmente por jasmim-café, é encontrada principalmente em áreas de Mata Atlântica do Estado de Pernambuco (MARINHO et al, 2016).…”

Section: Introductionunclassified

“…divaricata possui um grande destaque na medicina popular por ser uma fonte rica de vários tipos de alcaloides facilmente extraídos do látex ou das cascas do caule pelo processo de infusão (CHANCHAL et al, 2015;MARINHO et al, 2016). O seu uso já foi relatado como analgésico, anti-inflamatório, antioxidante, antiinfecção, antitumoral, usada no tratamento de dores abdominais, epilepsia, dor de garganta, no tratamento de fertilidade, e dores reumáticas (KUMAR; SELVAKUMAR, 2015).…”

Section: Introductionunclassified

“…O seu uso já foi relatado como analgésico, anti-inflamatório, antioxidante, antiinfecção, antitumoral, usada no tratamento de dores abdominais, epilepsia, dor de garganta, no tratamento de fertilidade, e dores reumáticas (KUMAR; SELVAKUMAR, 2015). Devido a sua importância medicinal, esta espécie tem atraído a atenção da comunidade científica para estudos de novos ingredientes ativos e o efeito farmacológico de cada molécula isolada (BAO et al, 2013;CHANCHAL et al, 2015;MARINHO et al, 2016;ALI KHAN et al, 2018). Apesar do crescente interesse no uso desses compostos poucos são os estudos até o momento da propagação vegetativa, técnica que utiliza caules, raízes ou folhas para a confecção de estacas em que objetivo principal é preservar as características encontradas na planta mãe no novo indivíduo (PIMENTA et al, 2017).…”

Section: Introductionunclassified

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Efeito De Diferentes Concentrações De Aib Na Propagação Por Estaquia De Tabernaemontana Divaricata (L.)

Souza¹,

Neto²,

Júnior³

et al. 2018

Agrarian

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RESUMOA espécie Tabernaemontana divaricata (família Apocynaceae), planta arbustiva conhecida vulgarmente por jasmim-café, possui um grande destaque na medicina popular, atraindo a atenção da comunidade científica para novos estudos. O objetivo deste trabalho foi analisar a formação de calo, raiz, e brotação em estacas de Tabernaemontana divaricata (L). em diferentes concentrações de ácido indolbutírico (AIB) (0, 2000, 4000 e 6000 ppm). As estacas lenhosas apresentaram maiores valores percentuais na formação de calo, raiz e brotação. Quanto ao efeito das concentrações de AIB, o tratamento de 2000 mg. L -1 apresentou os maiores valores, demonstrando ser este o tratamento mais indicado para a espécie avaliada. PALAVRAS-CHAVE: AIB (ácido indolbutírico), propagação por estaquia, Tabernaemontana divaricata (L.). EFFECT OF DIFFERENT CONCENTRATIONS OF IBA ON PROPAGATION BY CUTTINGS OF TABERNAEMONTANA DIVARICATA (L.)ABSTRACT The species Tabernaemontana divaricata (family Apocynaceae), ornamental bush is commonly known as crape jasmine, has a great prominence in folk medicine, attracting the attention of the scientific community to new studies. The aim of this work was to analyze the formation of callus, root, and sprouting in cuttings of Tabernaemontana divaricata (L). in different concentrations of indolebutyric acid (IBA) (0, 2000, 4000 and 6000 ppm). The woody cuttings presented higher percentage values in the formation of callus, root, and sprouting. As for the effect of AIB concentrations, the 2000 mg. L -1 treatment presented the highest values, showing that this treatment is the most appropriate treatment for the evaluated species.

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Brazilian Tabernaemontana genus: Indole alkaloids and phytochemical activities

Cited by 35 publications

References 56 publications

Identification of Phenolic Compounds from Hancornia speciosa (Apocynaceae) Leaves by UHPLC Orbitrap-HRMS

Identification of Phenolic Compounds from Hancornia speciosa (Apocynaceae) Leaves by UHPLC Orbitrap-HRMS

Anti-infective activities of 11 plants species used in traditional medicine in Malaysia

Efeito De Diferentes Concentrações De Aib Na Propagação Por Estaquia De Tabernaemontana Divaricata (L.)

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