Brands Of Ampiclox Against Clinical Strains Of Staphylococcus aureus

Abstract

Proliferation of different brands of antibiotics including ampiclox (a notable penicillinase inactivator) was considered a relevant factor in the antibiotic resistance of Staphylococcus aureus. Consequently the antibiogram and susceptibility of 20 clinical strains and a control strain (NCTC 6571) of Staphylococcus aureus to 10 different brands of ampiclox were determined by disk diffusion and tube broth dilution methods. The control strain was found sensitive to ampicilin, augmentin R and cloxacillin in the antibiogram, and to all the l0 brands of ampiclox, with the MIC's of either 0.125 or 0.25µg/mI among the clinical strains. This result, compared with the MIC's obtained in the range of 0.125µg/ml to > 60µg/mI, varying among the brands of ampiclox against the 20 clinical strains, indicates contrasting inhibitory activity among the different brands but reflective of the worrisome level of resistance to antibiotics by Staph. aureus. However, this resistance to most of the brands of ampic1ox could not be associated with brand variation having found the control strain sensitive to all the brands of ampiclox.

“An antibiotic turned contraceptive”: The tale of ampicillin‐cloxacillin

“…A more worrisome potential consequence of this menace is the rising incidence of microbial resistance to ampicillin‐cloxacillin in the country. Clinical strains of Staphylococcus aureus have shown resistance to various brands of ampicillin‐cloxacillin in Nigeria 13 . A previous study noted 100% resistance of Escherichia coli to ampicillin, 14 and another study noted high resistance of same organism to cloxacillin 14 in Nigeria.…”

Molecular screening of antibiotic-resistant determinants among multidrug-resistant clinical isolates of <i>Proteus mirabilis</i> from SouthWest Nigeria

“…Isolates harbouring ESBL genes were subjected to R-plasmid curing experiment using the modified method described by Adeleke et al (2002). 40 Briefly, the overnight culture of each ESBL-positive P. mirabilis strains was exposed to 200 and 100 μg/ml of ethidium bromide and incubated for 24 hours at 37 0 C. Pure colonies of the ethidium bromide treated and untreated isolates were first selected on MacConkey agar plates and then on Nutrient agar, after which they were then diluted to 0.5 MacFarland standard for susceptibility testing against selected antibiotics (cefotaxime, ceftazidime, aztreonam, ciprofloxacin, gentamicin and trimethoprim-sulphamethoxazole) by disc-diffusion method, and zones of inhibition interpreted by comparing with the CLSI guideline.…”

Isolation and identifi cation of pharmaceutically active lipase producing Bacillus spp. from mangrove sediments against Methicillin Resistant Staphylococcus aureus isolated from wound of patients

“…acquired in hospital) and dangerous human pathogen since publication of its role in sepsis by Ogston in 1880 and 1882 (Lowy, 1998). At present, Staphylococcal resistance to antibiotic has been associated with resistant plasmids (R-plasmid) that have the ability to mediate the production of drug inactivated enzymes such as -lactamase.The spread of resistance to antimicrobial agents in S. aureus is largely due to the acquisition of plasmids and or transposons (Lyon andSkurray, 1987Adeleke andOdelola, 1997;Adeleke et al, 2002 and other functions (King et al, 2006 andDiep et al, 2008).…”