Brain serotonin system in the coordination of food intake and body weight

Lam, Daniel D.; Garfield, Alastair S.; Marston, Oliver; Shaw, Jill; Heisler, Lora K.

doi:10.1016/j.pbb.2010.09.003

Cited by 234 publications

(188 citation statements)

References 119 publications

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“…Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that regulates feeding behaviour and BW (Lam et al, 2010). Two independent 5-HT systems exist: one is present in the brain and one in the periphery.…”

Section: Introductionmentioning

confidence: 99%

Enteric and serological distribution of serotonin and its precursor tryptophan in perinatal low and normal weight piglets

Willemen

Che

Dewilde

et al. 2014

Animal

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Perinatal mortality is high among small-for-gestational age (SGA) piglets and continues to be an economic burden and threat to animal welfare. As the physiological role of serotonin (5-hydroxytryptamine, 5-HT) in perinatal development and gastrointestinal function in the pig remains unknown, the aim of this study was to assess the enteric distribution of 5-HT cells and to determine 5-HT together with its precursor tryptophan in the serum of perinatal normal and SGA piglets. For this purpose, proximal and distal parts of the small intestine (SI) were processed for immunohistochemical analysis to assess the presence of 5-HT endocrine cells. Serum 5-HT was measured with ELISA, whereas its precursor, that is, the free fraction of tryptophan (FFT) together with albumin-bound tryptophan and total tryptophan, were analysed with HPLC in postnatal piglets. In addition, the morphological growth patterns of the different intestinal tissue layers of both normal and SGA piglets were stereologically analysed. The stereological volume density of 5-HT enteroendocrine cells showed a significant interaction effect between age and region. Indeed, the amount of 5-HT cells in both the proximal and distal part of the SI tended to decrease according to age, with the lowest values detected at day 3 postpartum. No differences could be observed related to BW. Interestingly, the serum concentration of 5-HT was higher in normal piglets compared with SGA piglets. Moreover, the ratio of FFT to total tryptophan was significantly affected by age and BW. Normal piglets had, on average, a lower FFT/total tryptophan ratio compared with SGA piglets. An approximate linear decrease was observed with increasing age. Finally, the immaturity of the intestinal system of the SGA piglets was not reflected in altered volume densities of the different intestinal layers. To conclude, although no BW effect could be detected in the distribution of enteric 5-HT cells, serum 5-HT and the ratio of FFT to total tryptophan ratio showed significant differences between normal piglets and their SGA littermates.Keywords: low birth weight, pig, serotonin, serum, small intestine ImplicationsThe use of hyperprolific sows in the pork industry increases the prevalence of prenatal growth-restricted piglets, characterised by reduced survival rates. Serotonin is prominently present in the gastrointestinal system and regulates feeding behaviour and BW. This study investigated the enteric distribution of serotonin cells and the concentration of this hormone along with its precursor tryptophan in the serum of perinatal SGA and normal littermates. These results -combined with the morphological analysis of the small intestine -will give insight into the endocrine programming and morphological adaptations of the small intestine of SGA piglets.

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Section: Introductionmentioning

confidence: 99%

Enteric and serological distribution of serotonin and its precursor tryptophan in perinatal low and normal weight piglets

Willemen

Che

Dewilde

et al. 2014

Animal

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“…Penelitian sebelumnya menyebutkan bahwa terdapat hubungan terbalik antara kadar serotonin dengan asupan makan dan berat badan (Lam et al, 2010). Penelitian menggunakan prekursor serotonin triptofan dan 5-hidroksitriptofan (5-HTP) membuktikan bahwa serotonin dapat menyebabkan penurunan nafsu makan pada tikus (Amer et al, 2004;Ceci et al, 1989).…”

Section: P E N D a H U L U A Nunclassified

PENGARUH PEMBERIAN EKSTRAK KULIT PISANG KEPOK KUNING (<em>Musa balbisiana</em>) TERHADAP ASUPAN MAKAN DAN BERAT BADAN TIKUS WISTAR (<em>Rattus norvegicus</em>) JANTAN

Fatchurohmah¹,

Meliala

2017

Scri. Biol.

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A B S T R A C TA positive energy imbalance results in overweight and obesity. Overweight and obesity are the major risk factors for many diseases, including diabetes, cardiovascular diseases, and mental health. Animal studies suggested that serotonin involves in food intake control. The Banana peel is a potential natural source of serotonin precursor; furthermore, it may influence food intake. This study aimed to determine the effect of banana peel extract on food intake and body weight gain in male Wistar rats. Twenty-four male Wistar rats (8-10 weeks old), were divided into four groups for feeding treatment. All four group were; the control group (C), the banana peel extract dosage of 4 g/kg BW group (T1), the banana peel extract dosage of 8 g/kg BW (T2), and the banana peel extract dosage of 16 g/kg BW (T3). The food intakes were measured daily, while rats body weights were recorded at the beginning and the end of the three days experimental periods. The study found the rats in the T1 group (8.80 ± 2.63) showed no significant difference in food intake compared to C group (10.68 ± 1.89), T2 group (6.65 ± 3.12), and T3 group (5.42 ± 1.59). Rats in the T2 group (p = 0.038) and T3 group (p = 0.005) showed lower food intake significantly compared to control group. After three days of treatment, the T3 group showed a significant decrease in body weight compared to control group (p = 0.008). This study concluded, the administration of banana peel extract dosage of 8 g/kg BW and 16 g/kg BW suppressed food intake, while the dosage of 16 g/kg BW reduced the body weight in male Wistar rats.KEY WORDS: food intake, banana peel, Wistar rat Penulis korespondensi: WIWIEK FATCHUROHMAH |

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“…Among them serotonin or 5-Hydroxytryptamin (5-HT) plays an interesting role and yet incompletely known up to this moment. Serotonin is generally known as connected to several disorders as anxiety, depression, autism, anorexia nervosa, gastro-intestinal maladies, neuroendocrine tumours, and potentially osteoporosis (but many issues are still a matter of debate) [8][9][10][11] . The molecule is named from the fact that is assayed in the serum and influence the vascular tone.…”

mentioning

confidence: 99%

“…The main enzyme is tryptophan hydroxylase: type 1 (Tph) is used in periphery while type 2 is seen exclusively in brain [8][9][10][11] . The monoamine has a specific class of 5-HT receptors (seven types) and plasma membrane transporters (5-HTT or SERT) that are interfered by drugs as SSRI (Selective Serotonine Re-uptake Inhibitors) [8][9][10][11] . Circulating 5-hydroxytryptamin represents the majority (95%) of body serotonin and it is produced by the enterochromaffin cells of the gut mainly with a paracrine function (influencing the peristalsis and the mucus secretion).…”

mentioning

confidence: 99%