Brain dysfunction during motor activation and corpus callosum alterations in Schizophrenia measured by cerebral blood flow and magnetic resonance imaging

Günther, W.; Petsch, R.; Steinberg, R.; Moser, E.; Streck, P.; Heller, H.; Kurtz, G.; Hippius, Hanns

doi:10.1016/0006-3223(91)90090-9

Cited by 101 publications

(38 citation statements)

References 49 publications

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“…11 This view is based on the similarities in the processes that govern the development of callosal and of other cortico-cortical connections. As mentioned earlier in this paper, both sets of 135 Smaller CC in negative symptom patients than in positive symptom patients. Positive correlation between CC size and cerebral blood flow.…”

Section: Developmental-pathogenic Scenariossupporting

confidence: 75%

“…A positive correlation between CC size and cerebral blood flow was also found. 135 Negative correlation between CC size and negative symptoms was found by Tibbo et al 81 The alterations in S patients with negative symptoms might relate to the anterior part of the CC, whose size appears to be reduced 80 and where abnormalities were localized with MTR. 92 In two separate studies 117,137 examining a total of 31 male, unmedicated patients, Merrin and collaborators reported a negative correlation between ICoh in the a band of the EEG and negative symptoms.…”

Section: Callosal Markers and Symptomatologymentioning

confidence: 92%

“…Results collected over the last decade are shown in Table 4. The important study of Gü nther et al 135 showed a decreased CC in 15 patients with negative symptoms, compared with 14 patients with positive symptoms. Although the differences with the carefully selected control subjects were statistically insignificant, not surprisingly due to the small sample, CC size in the control group fell between the two S groups.…”

Section: Callosal Markers and Symptomatologymentioning

confidence: 93%

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Schizophrenia, neurodevelopment and corpus callosum

2003

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The Zeitgeist favors an interpretation of schizophrenia as a condition of abnormal connectivity of cortical neurons, particularly in the prefrontal and temporal cortex. The available evidence points to reduced connectivity, a possible consequence of excessive synaptic pruning in development. A decreased thalamic input to the cerebral cortex appears likely, and developmental studies predict that this decrease should entail a secondary loss of both longand short-range cortico-cortical connections, including connections between the hemispheres. Indeed, morphological, electrophysiological and neuropsychological studies over the last two decades suggest that the callosal connections are altered in schizophrenics. However, the alterations are subtle and sometimes inconsistent across studies, and need to be investigated further with new methodologies.

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Section: Developmental-pathogenic Scenariossupporting

confidence: 75%

Section: Callosal Markers and Symptomatologymentioning

confidence: 92%

Section: Callosal Markers and Symptomatologymentioning

confidence: 93%

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Schizophrenia, neurodevelopment and corpus callosum

2003

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“…Although not regarded as a prime candidate, there is growing evidence from diverse sources including neuroimaging that the CC is a locus of interest in schizophrenia; the first MRI study suggested alterations in size and shape in schizophrenia [28] . Subsequent analyses have found conflicting results, including global increases [28,29] , reductions [30,31] or no differences [32,33] compared to healthy individuals, although a meta-analysis of the first decade of CC studies in schizophrenia suggests this structure is smaller in patients [34] . Data in subjects experiencing their first episode of schizophrenia suggest that the CC may also be smaller than in healthy individuals [32,35,36] .…”

Section: Discussionmentioning

confidence: 99%

First-Episode ‘Coenesthetic’ Schizophrenia Presenting with Alien Hand Syndrome and Partial Agenesis of the Corpus Callosum

et al. 2008

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We describe the case of a 23-year-old Caucasian woman who presented with alien hand syndrome and a first episode of the coenesthetic subtype of schizophrenia. ‘Alienness’ of her non-dominant hand was intimately phenomenologically associated with the onset of first-psychosis. Cerebral MRI revealed a partial agenesis of the corpus callosum with a complete absence of the rostrum, hypoplastic anterior and inferior genu, and a hypoplastic splenium. This case suggests that this syndrome can occur with the development of a functional disconnection syndrome involving the anterior callosum, and in this case the ‘second hit’ proposed to occur in early adulthood in schizophrenia may have interacted with her earlier neurodevelopmental lesion to result in a combination of psychosis and alien hand syndrome.

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“…Structural changes in the corpus callosum occur in a variety of neurological diseases. 23 Also, a substantial number of studies have investigated the corpus callosum in schizophrenia [24][25][26][27][28][29][30][31][32][33] with a meta-analysis of 11 studies suggesting that corpus callosum area ͑but not length or corpus callosum/brain ratio͒ in midsagittal images was decreased in schizophrenia patients compared to healthy controls. 34 In addition, some, 35,36 but not all 31,37 studies in mood disorders have reported changes in the corpus callosum.…”

Section: Introductionmentioning

confidence: 99%

Automated segmentation of the corpus callosum in midsagittal brain magnetic resonance images

et al. 2000

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Abstract. We propose a new algorithm to find the corpus callosum automatically from midsagittal brain MR (magnetic resonance) images using the statistical characteristics and shape information of the corpus callosum. We first extract regions satisfying the statistical characteristics (gray level distributions) of the corpus callosum that have relatively high intensity values. Then we try to find a region matching the shape information of the corpus callosum. In order to match the shape information, we propose a new directed window region growing algorithm instead of using conventional contour matching. An innovative feature of the algorithm is that we adaptively relax the statistical requirement until we find a region matching the shape information. After the initial segmentation, a directed border path pruning algorithm is proposed in order to remove some undesired artifacts, especially on the top of the corpus callosum. The proposed algorithm was applied to over 120 images and provided promising results.

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Brain dysfunction during motor activation and corpus callosum alterations in Schizophrenia measured by cerebral blood flow and magnetic resonance imaging

Cited by 101 publications

References 49 publications

Schizophrenia, neurodevelopment and corpus callosum

Schizophrenia, neurodevelopment and corpus callosum

First-Episode ‘Coenesthetic’ Schizophrenia Presenting with Alien Hand Syndrome and Partial Agenesis of the Corpus Callosum

Automated segmentation of the corpus callosum in midsagittal brain magnetic resonance images

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