First-Episode ‘Coenesthetic’ Schizophrenia Presenting with Alien Hand Syndrome and Partial Agenesis of the Corpus Callosum

Simon, Andor E.; Walterfang, Mark; Petralli, C; Velakoulis, Dennis

doi:10.1159/000170392

Cited by 8 publications

(8 citation statements)

References 77 publications

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“…To our knowledge, two case studies have been published examining WM abilities in AgCC, both adults. However, results are contradictory, with impaired performance on a 2-back task in one case (Simon et al, 2008), and average performance on auditory-verbal and visual WM tasks in the second case (Reddy et al, 2010). In addition, Sauerwein and Lassonde (1994) reported working memory performance below the average range but not significantly different from the control group in 9 individuals with AgCC from 10 to 29 year-old.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of working memory in children and adolescents with agenesis of the corpus callosum: An fMRI study

et al. 2017

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A B S T R A C TThe ability to temporarily maintain relevant information in mind in the presence of interference or distracting information, also called working memory (WM), is critical for higher cognitive functions and cognitive development. In typically developing (TD) children, WM is underpinned by a fronto-parietal network of interacting left and right brain regions. Developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation resulting from disruption of corpus callosum formation. This study aims to investigate functional organisation of WM in children and adolescents with AgCC using functional magnetic resonance imaging (fMRI). Nine children with AgCC and a comparison group of sixteen TD children aged 8-17 years completed an fMRI WM paradigm designed to enable investigation of different WM processes, i.e., encoding, maintenance and retrieval. We found that AgCC children recruited globally similar brain regions as the TD comparison group during the WM task, despite significant disparity in brain development, i.e., bilateral occipitofrontal activations during verbal encoding, and bilateral fronto-parietal executive control network during retrieval. However, compared to their TD peers, children with AgCC seemed less able to engage lateralised brain systems specialised for particular memory material (i.e. less supramarginal activations for verbal material and less fusiform activations for face processing) and particular memory process (i.e. absence of right-predominant activations during retrieval). Group differences in the pattern of activation might also reflect different cognitive strategies to cope with competition in processing resources with different susceptibility to concurrent tasks (verbal vs visual), such as differential recruitment of associative visual areas and executive prefrontal regions in the AgCC compared with the TD group depending on the concurrent task completed during maintenance. This study provides a first step towards a better understanding of functional brain networks underlying higher cognitive functions in children with AgCC.

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Section: Introductionmentioning

confidence: 99%

Neural correlates of working memory in children and adolescents with agenesis of the corpus callosum: An fMRI study

et al. 2017

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“…We found several clinical cases reporting associations between lesions of the corpus callosum and psychotic manifestations that illustrate the pathophysiologic involvement of this structure in secondary psychosis (Figure 3, Supplementary Table 3). In complete or partial agenesis of the corpus callosum (Bhatia 2016;Simon et al 2008), or in X-linked adrenoleukodystrophy (Smith, Williams, and Misra 2018), delusions and hallucinations may be in the foreground, sometimes without association with neurological symptomatology. Corpus callosum's pathogenicity in psychosis is also highlighted by the description of a reversible splenial lesion in a teenager treated for a nephrotic syndrome.…”

Section: In Secondary Psychosismentioning

confidence: 99%

Brain anomalies in early psychosis: From secondary to primary psychosis

Iftimovici

Chaumette

Duchesnay

et al. 2022

Neuroscience & Biobehavioral Reviews

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“…The CC plays the main role in integrating information from both hemispheres; it controls thought as well as emotional and behavioral processes [ 24 ]. The participation of the CC in the pathogenesis of psychosis is indicated by reports of cases of psychotic symptoms when partial or complete agenesis of the CC has occurred [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients

Podwalski

Tyburski

Szczygieł

et al. 2021

JCM

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Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-deficit schizophrenia (NDS) patients. We also investigated the psychopathological dimensions of schizophrenia and their relationship to CC integrity. Fifteen DS patients, 40 NDS patients, and 30 healthy controls (HC) underwent psychiatric evaluation and neuroimaging. We divided the CC into five regions and assessed their fractional anisotropy (FA) and mean diffusivity (MD). Psychopathology was assessed with the Positive and Negative Syndrome Scale. DS patients had lower FA than NDS patients and HC, and higher MD in Region 5 of the CC than did HC. NDS patients had higher MD in Region 4 of the CC. The patient groups differed in terms of negative symptoms. After differentiating clinical groups and HC, no significant correlations were observed between DTI measures and psychopathological symptoms. Our results suggest that DS and NDS are characterized by minor impairments of the posterior CC. We confirmed that DS patients have greater negative psychopathology than NDS patients. Our results are preliminary, and further studies are needed.

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First-Episode ‘Coenesthetic’ Schizophrenia Presenting with Alien Hand Syndrome and Partial Agenesis of the Corpus Callosum

Cited by 8 publications

References 77 publications

Neural correlates of working memory in children and adolescents with agenesis of the corpus callosum: An fMRI study

Neural correlates of working memory in children and adolescents with agenesis of the corpus callosum: An fMRI study

Brain anomalies in early psychosis: From secondary to primary psychosis

White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients

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