Brain Connectivity and the Spread of Epileptic Seizures

Milton, John; Chkhenkeli, S. A.; Towle, Vernon L.

doi:10.1007/978-3-540-71512-2_17

Cited by 20 publications

(17 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental evidence exists for both and accumulates with every day (Koch 1999). Most likely a synchronized neural dynamics will play a lesser role for extended periods of time during which a large scale synchronization is more likely to indicate pathological network activity such as epilepsy (see Milton et al 2007). However, the understanding of the conditions leading to the emergence of synchronization will likely be important to understanding the neurocognitive processes such as feature binding (Crick and Koch 1990;Singer and Gary 1995) and multisensory integration (Treisman 1986;Von Stein et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Dispersion and time delay effects in synchronized spike–burst networks

Jirsa

2007

Cogn Neurodyn

View full text Add to dashboard Cite

We study spike-burst neural activity and investigate its transitions to synchronized states under electrical coupling. Our reported results include the following: (1) Synchronization of spike-burst activity is a multi-time scale phenomenon and burst synchrony is easier to achieve than spike synchrony. (2) Synchrony of networks with time-delayed connections can be achieved at lower coupling strengths than within the same network with instantaneous couplings. (3) The introduction of parameter dispersion into the network destroys the existence of synchrony in the strict sense, but the network dynamics in major regimes of the parameter space can still be effectively captured by a mean field approach if the couplings are excitatory. Our results on synchronization of spiking networks are general of nature and will aid in the development of minimal models of neuronal populations. The latter are the building blocks of large scale brain networks relevant for cognitive processing.

show abstract

Section: Introductionmentioning

confidence: 99%

Dispersion and time delay effects in synchronized spike–burst networks

Jirsa

2007

Cogn Neurodyn

View full text Add to dashboard Cite

show abstract

“…It was also reported that the global dynamics in the network topology was influenced by frequent epileptic ictal (16). With the voxel-based analysis (VBA) method statistical analysis is globally performed on a voxel-by-voxel basis.…”

mentioning

confidence: 99%

Microstructural brain abnormalities of children of idiopathic generalized epilepsy with generalized tonic‐clonic seizure: A voxel‐based diffusional kurtosis imaging study

Gao

Feng

et al. 2014

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…One point to be remarked in this regard is that propagation of seizures to distant areas is generally much faster than the predicted horizontal intracortical rate of 6 -18 cm/s, suggesting the existence of several routes, instead of a single intracortical spread [26][27][28]. Propagation through white matter and subcortical nuclei-mediated spread may enable the seizure to reach distant cortical areas very fast.…”

Section: Discussionmentioning

confidence: 99%

New network and synchronization approaches in focal epilepsy research and treatment

Pastor¹,

Sola²,

Zelaya³

et al. 2013

Health

View full text Add to dashboard Cite

Traditional approaches to focal epileptic surgery rely in the identification and resection of the epileptic zone. However, a significant minority of epileptic patients continue to experience seizures after surgery, a fact that shows how difficult it is to define this concept. In this work we will review some of the recent advances in the use of complex network theory and synchronization analysis in the study of neurophysiological epileptic records which shed new light on fragmented understanding of the epilepsy dynamic we have today. More important would be the potential treatments which could be implemented from the new information and change of perspective gathered by using this methodology, particularly the substitution of the traditional resective surgery in temporal lobe epilepsy patients.

show abstract

Brain Connectivity and the Spread of Epileptic Seizures

Cited by 20 publications

References 92 publications

Dispersion and time delay effects in synchronized spike–burst networks

Dispersion and time delay effects in synchronized spike–burst networks

Microstructural brain abnormalities of children of idiopathic generalized epilepsy with generalized tonic‐clonic seizure: A voxel‐based diffusional kurtosis imaging study

New network and synchronization approaches in focal epilepsy research and treatment

Contact Info

Product

Resources

About