The effects of electrostimulation of caput nuclei caudati (CNC) were investigated in 57 patients. Long-term implanted multicontact electrodes were used in 38 patients. In 23 cases, completely implanted neurostimulators and in the remaining 15 cases externalized electrodes were used. Investigations demonstrated that a low-frequency (4–6 Hz) stimulation of certain points of the ventral part of CNC reliably led to (1) a decrease of interparoxysmal activity in the neo-cortical and mesial temporal epileptic foci; (2) a decrease of focal discharges in the aforementioned areas, and (3) abrupt cessation of spreading and generalized discharge.
Therapeutic brain stimulation was applied in 74 patients with resistant forms of epilepsy. It was shown that low frequency stimulation of certain zones of the head of the caudate nucleus and higher frequency stimulation of the dentate nucleus of the cerebellum lead to a marked suppression of interparoxysmal epileptic activity and to a disruption of both focal and generalized epileptic discharges. It is necessary to determine, by means of stereo-electroencephalography, the variability for localizing the inhibitory zones of the structures to implant the neurostimulators exactly.
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