Bovine Papular Stomatitis in a Japanese Black Calf

Molecular phylogenetic analysis of bovine papular stomatitis viruses detected in Saga, Japan

“…The oral papular stomatitis in this study exhibited histopathological findings consistent with a previous report, and was distinct from FMD, BVD-MD and IBR histopathology as it did not exhibit proliferative changes of spinous cells [26]. Furthermore, it was confirmed that this lesion was caused by parapoxvirus by using immunohistochemical staining and electron microscopy.…”

Successful measures to prevent the spread of bovine papular stomatitis in a dairy farm

“…LC487905). Based on a phylogenetic analysis, it was classified into the same cluster as the strains isolated in the Nara Prefecture in 2015 [3] and Iwate Prefecture in 2007 [15] (Fig. 3).…”

Molecular Analysis of Parapoxvirus Detected in Eight Calves in Japan

“…Nucleotide and amino acid sequences obtained were compared with each other with BPSV (V660; GenBank Accession No. AB044793), PCPV (VR634; AB044792) and PVNZ (DPV; AB044794) reference strains [ 7 , 8 ] and with BPSV 9108 (JN162119) [ 2 ] and BPSV Iwate/bovine/2007 (AB538385) [ 15 ]. For detailed phylogenetic analyses, sequences of 12 previously reported virus isolates from Japan [ 8 ] and other countries [ 2 ] were used (AB044795–AB044801, JN171854, JN171860, JN171861, JN191576 and AY386265).…”

“…These substitutions might be the result of exposure to some as yet unidentified immunological pressures. The nucleotide sequence of amplicon B was identical to that of BPSV Iwate/bovine/2007 detected in a calf from Iwate Prefecture in 2007 [ 15 ]. Based on the phylogenetic tree we constructed, seven of the detected amplicons (A–G) could be considered BPSV; however, the sequence of amplicon H was most similar to that of PCPV ( Fig.…”

“…Because the asymptomatic calves had been raised with one symptomatic calf at each farm, the calves might have been subclinically infected with the virus. Parapoxvirus infections with clinical symptoms in cattle have rarely been reported in this prefecture [ 15 ], although a high rate of antibodies positive against parapoxvirus has been found [ 14 ]. The increase in the level of detection is likely a consequence of increased surveillance by veterinarians and farmers following a foot-and-mouth disease outbreak in the spring of 2010 in Japan.…”