Bovine leucosis (lymphosarcoma): a clinical study of 60 pathologically confirmed cases

Abstract

The clinical features of 60 pathologically confirmed cases of bovine leucosis (lymphosarcoma) are described. The majority of cases could be classified into one of four distinct clinical forms, ie, juvenile multicentric, thymic, skin and adult multicentric. Diagnosis of leucosis in animals with these forms was possible on clinical grounds alone. Five animals, four of which were adult, could not be thus classified and diagnosis required haematological and, or, pathological examinations. The clinical, epidemiological and serological findings would suggest that the cases were examples of sporadic bovine leucosis.

Signalment and Clinical Complaints Initiating Hospital Admission, Methods of Diagnosis, and Pathological Findings Associated with Bovine Lymphosarcoma (112 Cases)

“…2 A clinical study of 60 pathologically confirmed cases of bovine lymphosarcoma was published in 1979, but these cases were mostly (78%) the calf multicentric and juvenile thymic forms. 3 A large retrospective study over 4 years on carcass condemnation rates for malignant lymphosarcoma in cattle in 2 abattoirs was conducted in California. However, this paper did not go into detail on the signalment, clinical signs, or organs affected.…”

Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma em bovinos: 128 casos (1965-2013)

“…Manifestações clínicas que demonstram alterações no sistema respiratório (dispneia, taquipneia e estertoração pulmonar) foram observadas em aproximadamente um terço dos bovinos acometidos por linfoma neste estudo. Estas alterações estão diretamente relacionadas com aumento de linfonodos que envolvem o trato respiratório principalmente os mediastínicos, submandibulares e traqueobrôn-quicos (Marshak et al 1962, Grimshaw et al 1979, Ivany et al 2000, Barros 2007, Radostits et al 2007, Garry 2008. Além dos linfonodos, houve acometimento pulmonar em alguns casos, contribuindo para o agravamento dos sinais respiratórios.…”

Pathology in Practice

“…3,4 In contrast, sporadic bovine lymphoma develops in young animals (often < 3 years old). 3,5 The calf form affects animals < 6 months old and results in lymph node enlargement with neoplastic infiltration of hematopoietic tissues in the bone marrow, liver, thymus, and spleen. 2 A genetic origin is also possible because familial thymic lymphoma has been reported.…”

“…2 A genetic origin is also possible because familial thymic lymphoma has been reported. 5 The thymic form affects bovids that are 6 months to 2 years old. 3,5 The calf form affects animals < 6 months old and results in lymph node enlargement with neoplastic infiltration of hematopoietic tissues in the bone marrow, liver, thymus, and spleen.…”

“…6 There are 3 forms of sporadic bovine lymphoma, including a calf form, cutaneous form, and thymic form. 3,5,8 There are multiple reports 1,3,5,8 of cases that are transitional between the calf and thymic forms. 3,7 The cutaneous form results in multiple cutaneous to subcutaneous nodules and enlarged peripheral lymph nodes.…”