Botryorhodines A–D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa

Antiproliferative Effects of Ester‐ and Amide‐Functionalized Rhizoxin Derivatives

“…[28,29] For comparison, the activities of the known methyl ester 3 were also determined in this study, as no activities against HUVEC cells were published. Surprisingly, the nature of the alcohol component in the ester derivatives 3-12 had no significant impact on their GI 50 (antiproliferative) and CC 50 (cytotoxic) concentrations (Table 1).…”

Bioproduction of Depsidones for Pharmaceutical Purposes

“…Alternatively, some non-lichenized fungi are also able to produce depsidones with cytotoxic activity. An endophytic fungus (Botryosphaeria rhodina), isolated from the stems of the medicinal plant Bidens pilosa, produces four depsidones, botryorhodines A-D, which exhibit potent cytotoxic and antiproliferative effects against several cancer cell lines, such as HeLa cells (Abdou et al, 2010). Ten depsidones, mollicellins, produced by the fungus Chaetomium brasiliense, showed also cytotoxic activity against KB, BC1, NCI-H187 lines, and five cholangiocarcinoma cell lines (Khumkomkhet et al, 2009 Some depsidones have been found in higher plants.…”

New Polyketides Isolated from Botryosphaeria australis Strain ZJ12‐1A

“…Various compounds were isolated from the genus Botryosphaeria. Some of them showed interesting biological activities; i.e., antifungal and cytotoxic depsidones [6], antimicrobe diterpenoids [7] and antiseptic mellein [8], antimicrobial lasiodiplodin [9], dihydronaphthalenones [10], and dihydrobenzofuran, and antibacterial primin [11]. The current study on the chemical constituents of strain ZJ12-1A resulted in the isolation of four new naphthalenones, named botryosphaerones A -D (1 -4, resp.…”