Bioproduction of Depsidones for Pharmaceutical Purposes

Legaz, Marı́a Estrella; Armas, R. de; Vicente, Carlos

doi:10.5772/27051

Cited by 2 publications

(1 citation statement)

References 64 publications

(53 reference statements)

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“…Orsellinates are believed to be involved in allelopathic interactions, exhibiting a rather weak antifungal effect [16,22,23]. Orsellinic acid itself is formed in the acetate-malonate pathway and is an intermediate for many phenolic compounds [24]. Many natural phthalides display a variety of biological activities.…”

Section: Changes In the Metabolomic Profile Of Fungi During Ontogenesismentioning

confidence: 99%

Metabolomic Changes in Wood Inhabiting Filamentous Fungi during Ontogenesis

Sazanova¹,

Psurtseva²,

Шаварда³

2021

Metabolomics - Methodology and Applications in Medical Sciences and Life Sciences

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GC–MS-based metabolomic profiling of different strains of basidiomycetes Lignomyces vetlinianus, Daedaleopsis tricolor and Sparassis crispa were studied. On different stages of growth in the methanol extracts of mycelium the different compounds including amino acids, organic acid of TCA cycle, sugars, fatty acids, sugar alcohols, and sugar acids were detected. Changes in the metabolite network occurring with age of the mycelium of L. vetlinianus and D. tricolor are discussed. The exponential phase of mycelium growth is characterized by pronounced differences during of growth, which manifests itself both in the analysis of specific compounds and in the modeling of the statistical model of the metabolic network. The metabolomic network in the stationary growth phase is less susceptible to changes over time, and is also characterized by a lower dispersion of samples from one aging group. For some compounds, including biotechnologically significant ones, targeted analysis by GC–MS was performed. 4, 6-dimethoxy-phthalide (4, 6-dimetoxy-1 (3H) -isobenzofuranone) was isolated from the mycelium of Lignomyces vetlinianus, accumulating in the mycelium in the form of large aggregates. The accumulation of sparassol and other orsellinic acid derivatives in Sparassis crispa culture under various conditions is described.

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Section: Changes In the Metabolomic Profile Of Fungi During Ontogenesismentioning

confidence: 99%

Metabolomic Changes in Wood Inhabiting Filamentous Fungi during Ontogenesis

Sazanova¹,

Psurtseva²,

Шаварда³

2021

Metabolomics - Methodology and Applications in Medical Sciences and Life Sciences

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Lichen Depsidones with Biological Interest

et al. 2021

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Depsidones are some of the most abundant secondary metabolites produced by lichens. These compounds have aroused great pharmacological interest due to their activities as antioxidants, antimicrobial, and cytotoxic agents. Hence, this paper aims to provide up-to-date knowledge including an overview of the potential biological interest of lichen depsidones. So far, the most studied depsidones are fumarprotocetraric acid, lobaric acid, norstictic acid, physodic acid, salazinic acid, and stictic acid. Their pharmacological activities have been mainly investigated in in vitro studies and, to a lesser extent, in in vivo studies. No clinical trials have been performed yet. Depsidones are promising cytotoxic agents that act against different cell lines of animal and human origin. Moreover, these compounds have shown antimicrobial activity against both Gram-positive and Gram-negative bacteria and fungi, mainly Candida spp. Furthermore, depsidones have antioxidant properties as revealed in oxidative stress in vitro and in vivo models. Future research should be focused on further investigating the mechanism of action of depsidones and in evaluating new potential actions as well as other depsidones that have not been studied yet from a pharmacological perspective. Likewise, more in vivo studies are prerequisite, and clinical trials for the most promising depsidones are encouraged.

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Bioproduction of Depsidones for Pharmaceutical Purposes

Cited by 2 publications

References 64 publications

Metabolomic Changes in Wood Inhabiting Filamentous Fungi during Ontogenesis

Metabolomic Changes in Wood Inhabiting Filamentous Fungi during Ontogenesis

Lichen Depsidones with Biological Interest

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