Both the microbiome and the macrobiome can influence immune responsiveness 
in psoriasis

Kierasińska, Magdalena; Donskow‐Łysoniewska, Katarzyna

doi:10.5114/ceji.2021.110314

Cited by 5 publications

(4 citation statements)

References 50 publications

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“… 106 , 124 Several studies have shown that Bacteroides produces polysaccharide A, activates Tregs and promotes the anti-inflammatory response. 158 , 164–166 Thus, a remarkable reduction in Bacteroides count in psoriasis could lead to immune alteration and pro-inflammatory response. 158 As the natural colonizers of the mucin layer in the human gut, Akkermansia muciniphila and Ruminoccocus prevent pathogen colonization by competitive inhibition.…”

Section: Methodsmentioning

confidence: 99%

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

et al. 2022

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The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and the immune system is impaired, subsequent effects can be triggered on the skin, potentially promoting the development of skin diseases. The mechanisms through which the gut microbiome affects skin health are still unclear. Enhancing our understanding on the connection between skin and gut microbiome is needed to find novel ways to treat human skin disorders. In this review, we systematically evaluate current data regarding microbial ecology of healthy skin and gut, diet, pre- and probiotics, and antibiotics, on gut microbiome and their effects on skin health. We discuss potential mechanisms of the gut-skin axis and the link between the gut and skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. This review will increase our understanding of the impacts of gut microbiome on skin conditions to aid in finding new medications for skin-associated diseases.

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Section: Methodsmentioning

confidence: 99%

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

et al. 2022

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“…The gut microbiome’s diversity can have a significant impact on immunological development and disease risk, especially for autoimmune conditions, such as psoriasis [ 35 ]. Intestinal microbiota dysbiosis in psoriasis patients depends on the severity and status of the disease ( Figure 2 ).…”

Section: Gut Microbiome Alterations In Psoriasismentioning

confidence: 99%

Gut Microbiota in Psoriasis

et al. 2022

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Psoriasis is a chronic inflammatory skin disease with autoimmune pathogenic characteristics and is caused by chronic inflammation, which results in uncontrolled keratinocyte growth and defective differentiation. The link between the gut microbiota and immune system regulation opened a novel angle to understand the pathogenesis of many chronic multifactorial diseases, including psoriasis. Current evidence suggests that modulation of the gut microbiota, both through dietary approaches and through supplementation with probiotics and prebiotics, could represent a novel therapeutic approach. The present work aims to highlight the latest scientific evidence regarding the microbiome alterations of psoriatic patients, as well as state of the art insights in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis.

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“…increases in psoriatic skin, while the abundance of Staphylococcus epidermidis, Cutibacterium acnes, and Cutibacterium granulosum decreases [11,12,72]. The Firmicutes to Bacteroidetes ratio (F/B ratio), two main phyla of the human gut microbiota, increases in patients with psoriasis, directly correlated with PASI scores and psoriasis comorbidities [8,[13][14][15][16]. Augmentation of Ruminococcus gnavus increased and underrepresentation of Faecalibacterium prausnitzii and Akkermansia muciniphila were also found in the intestinal microbiota of patients with psoriasis [8-10, 13, 15, 16, 70, 73].…”

Section: Gut Skin and Oral Microbiota In Psoriasismentioning

confidence: 99%

“…The pathophysiology of psoriasis is multifactorial, but the essential part is immune-mediated inflammation with IL-17 and IL-23 as key players that result in uncontrolled proliferation and dysfunctional differentiation [1,7]. Interestingly, recent studies have shown a significant difference between the human microbiota of patients with psoriasis and the normal population, with particular genera and species of skin microbiota clearly identified on the lesional skin and disproportions of the gut microbiota that influence the pathogenesis of psoriasis via the gut-skin axis [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Cannabis Transdermal Patch for Alleviating Psoriasis Symptoms: Protocol for a Randomized Controlled Trial (CanPatch)

Sermsaksasithorn

Asawanonda

Phutrakool

et al. 2023

Preprint

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Background: Existing topical psoriasis treatments are partially effective or have long-term side effects for a proportion of people with psoriasis; therefore, effective and safe treatment options are required. Cannabidiol, a cannabinoid in Cannabis sativa, reverses the etiology of psoriasis through skin receptors according to in vitro research. Cannabidiol transdermal patches may be an effective treatment for psoriasis, although the efficacy and safety data are limited. Methods and analysis: This is a randomized double-blind controlled trial comparing cannabidiol (CBD) with minimal tetrahydrocannabinol (THC) patches with placebo patches (1:1 ratio) daily applied to comparable lesions of each patient with mild to moderate plaque-type psoriasis performed in a university hospital in Thailand (n=60). The primary outcome is the local psoriasis severity index (LPSI). The local severity index of psoriasis, the itch score using the visual analog scale, and adverse events will be evaluated on day 0, 30, 60, and 90 of the study. Furthermore, on days 0 and 90 of this study, biological samples will be taken for the evaluation of the skin, gut, and mouth microbial profile of 50% of randomly selected individuals. Conclusions: This study aims to investigate the efficacy and safety of cannabidiol transdermal patches in alleviating the symptoms of psoriasis. We will also examine personal impacts on the efficacy and safety of patches, such as the microbial profile. The results of this study may highlight a novel topical treatment option that reduces suffering in patients with psoriasis. Ethics and dissemination: This study was registered with the Thai Clinical Trials Registry (TCTR No. 20220518004). The protocol is being considered by the Institutional Review Board of the Faculty of Medicine, Chulalongkorn University. The results of this study will be faithfully presented through conferences or published articles.

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Both the microbiome and the macrobiome can influence immune responsiveness in psoriasis

Cited by 5 publications

References 50 publications

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Gut Microbiota in Psoriasis

Efficacy and Safety of Cannabis Transdermal Patch for Alleviating Psoriasis Symptoms: Protocol for a Randomized Controlled Trial (CanPatch)

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