Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Mahmud, Md. Rayhan; Akter, Sharmin; Tamanna, Sanjida Khanam; Mazumder, Lincon; Esti, Israt Zahan; Banerjee, Sanchita; Akter, Sumona; Hasan, Md. Rakibul; Acharjee, Mrityunjoy; Hossain, Md. Sajjad; Pirttilä, Anna Maria

doi:10.1080/19490976.2022.2096995

Cited by 97 publications

(105 citation statements)

References 253 publications

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“…Considering the wide-ranging appreciation for the potential of diet to influence the microbiome [ 46 , 47 ], the broad and profound impact of the microbiome on human health and well-being [ 48 , 49 ], and, in particular, an increasing appreciation of the gut–skin axis [ 50 ], we compared the relative composition and abundance of the microbiota in these two populations. From the outset of the study (Day 15), differences in taxonomic, enzymic and pathway analyses were striking.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema

et al. 2022

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Over three million Americans are affected by skin cancer each year, largely as a result of exposure to sunlight. The purpose of this study was to determine the potential of grape consumption to modulate UV-induced skin erythema. With 29 human volunteers, we report that nine demonstrated greater resistance to UV irradiation of the skin after consuming the equivalent of three servings of grapes per day for two weeks. We further explored any potential relationship to the gut–skin axis. Alpha- and beta-diversity of the gut microbiome were not altered, but grape consumption modulated microbiota abundance, enzyme levels, and KEGG pathways. Striking differences in the microbiome and metabolome were discerned when comparing the nine individuals showing greater UV resistance with the 20 non-responders. Notably, three urinary metabolites, 2′-deoxyribonic acid, 3-hydroxyphenyl acetic and scyllo-inositol, were depressed in the UV-resistant group. A ROC curve revealed a 71.8% probability that measurement of urinary 2′-deoxyribonic acid identifies a UV skin non-responder. 2′-Deoxyribonic acid is cleaved from the DNA backbone by reactive oxygen species. Three of the nine subjects acquiring UV resistance following grape consumption showed a durable response, and these three demonstrated unique microbiomic and metabolomic profiles. Variable UV skin sensitivity was likely due to glutathione S-transferase polymorphisms. We conclude that a segment of the population is capable of demonstrating greater resistance to a dermal response elicited by UV irradiation as a result of grape consumption. It is uncertain if modulation of the gut-skin axis leads to enhanced UV resistance, but there is correlation. More broadly, it is reasonable to expect that these mechanisms relate to other health outcomes anticipated to result from grape consumption.

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Section: Discussionmentioning

confidence: 99%

Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema

et al. 2022

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“…Helicobacter pylori can produce cytotoxins and cause gastric mucosal inflammation by proliferating and producing nitric oxide. It can alter physiological processes such as vasodilation, inflammation, and immune regulation (Mahmud et al, 2022). Rosacea is also associated with H. pylori seropositivity (Holmes, 2013).…”

Section: Study On the Gastrointestinal Microbiota Of Patients With Ro...mentioning

confidence: 99%

Role of the skin microbiota and intestinal microbiome in rosacea

2023

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Rosacea is a chronic inflammatory cutaneous disorder of uncertain etiology that mainly affects the centrofacial region, including cheeks, nose, chin, forehead, and eyes. The pathogenesis of rosacea remains unclear because it involves several complex factors. Additionally, the potential treatment methods need to be explored. We reviewed the common bacterial species in the skin microbiota and gut microbiota of rosacea patients such as Demodex folliculorum, Staphylococcus epidermidis, Bacillus oleronius, Cutibacterium acnes, and Helicobacter pylori and identified their role in the pathogenesis. Besides, we summarized the influence factors such as temperature and age on rosacea patients. We also systematically reviewed the commonly used clinical treatment methods, including antibiotics, probiotics. as well as their treatment mechanism and application precautions.

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“…That is, when the relationship between gut microbes and the immune system is compromised, subsequent effects on the skin can be triggered and even develop into skin diseases. Therefore, skin diseases may be diagnosed through the detection of gut microbes ( Mahmud et al, 2022 ).…”

Section: Ai and Skin Diseases As Related To The Gut-skin Axismentioning

confidence: 99%

Artificial Intelligence in microbiomes analysis: A review of applications in dermatology

Sun

Niu

et al. 2023

Front. Microbiol.

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Microorganisms are closely related to skin diseases, and microbiological imbalances or invasions of exogenous pathogens can be a source of various skin diseases. The development and prognosis of such skin diseases are also closely related to the type and composition ratio of microorganisms present. Therefore, through detection of the characteristics and changes in microorganisms, the possibility for diagnosis and prediction of skin diseases can be markedly improved. The abundance of microorganisms and an understanding of the vast amount of biological information associated with these microorganisms has been a formidable task. However, with advances in large-scale sequencing, artificial intelligence (AI)-related machine learning can serve as a means to analyze large-scales of data related to microorganisms along with determinations regarding the type and status of diseases. In this review, we describe some uses of this exciting, new emerging field. In specific, we described the recognition of fungi with convolutional neural networks (CNN), the combined application of microbial genome sequencing and machine learning and applications of AI in the diagnosis of skin diseases as related to the gut-skin axis.

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Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Cited by 97 publications

References 253 publications

Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema

Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema

Role of the skin microbiota and intestinal microbiome in rosacea

Artificial Intelligence in microbiomes analysis: A review of applications in dermatology

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