Both plasma and tumor tissue miR-146a high expression correlates with prolonged overall survival of surgical patients with intrahepatic cholangiocarcinoma

Abstract

The purpose of this study was to investigate the association of tumor tissue and plasma miR-146a/b expressions with the clinicopathological properties and overall survival (OS) in surgical patients with intrahepatic cholangiocarcinomas (ICC).Eighty-seven patients with ICC were enrolled. Tumor tissue and plasma sample were collected and miR-146a/b expressions were assessed by quantitative polymerase chain reaction (qPCR). The median follow-up duration was 31 months, and the last follow-up date was January 2017.miR-146a (P < .001) and miR-146b (P = .006) expressions in tumor tissue were positively associated with that in plasma. Tissue miR-146a was negatively correlated with age (P = .036), poor differentiation (P = .020), N stage (P = .020), and TNM stage (P = .007), as well as ECOG performance (P = .008), whereas plasma miR-146a was inversely associated with N stage (P = .003), TNM stage (P = .003), and ECOG performance (P = .011). Moreover, tissue miR-146b was negatively correlated with gender (P = .043) and T stage (P = .047). Kaplan-Meier curves suggested that high expression of tissue miR-146a (P < .001) and plasma miR-146a (P = .029) were correlated with prolonged OS. Nevertheless, no association of miR-146b expression in tumor tissue (P = .187) and plasma (P = .336) with OS was discovered. Univariate analysis indicated that both tissue miR-146a (P < .001) and plasma miR-146a (P = .035) could predict better OS, whereas multivariate analysis revealed that only tissue miR-146a (P = .001) high expression was an independent factor for prolonged OS.Both plasma and tissue miR-146a expression correlated with favorable OS, whereas only tissue miR-146a was an independent prognostic biomarker in surgical patients with ICC.

MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly

“…More importantly, emerging evidence indicated that FN expression is highly associated with poor overall survival rates in variety of cancer types such as colorectal and gastric cancer [51,52]. On the other hand, high expression of miR-146a were correlated with prolonged overall survival [53]. Based on our finding, the FN assembly is negative correlation with miR-146a regarding to cancer patients overall survival rates.…”

Enhanced plasma miR‑142‑5p promotes the progression of intrahepatic cholangiocarcinoma via targeting PTEN

“…MicroRNAs (miRs) are small non-coding RNAs ~22 nucleotides in length that are associated with multiple biologic processes including cell proliferation, differentiation and apoptosis (7). Abnormal expression of miRNAs has been widely identified in different diseases (8,9).…”

“…For instance, miR-590-3p inhibits epithelial-mesenchymal transition in ICC via suppressing Smad interacting protein 1 expression (9). Additionally, several differentially expressed miRNAs have been reported as potential diagnostic biomarkers for patients with ICC; for instance, high miR-146a expression in the plasma and tumor tissues is reportedly associated with prolonged overall survival in surgical patients with ICC (7).…”