Bostrycin inhibits growth of tongue squamous cell carcinoma cells by inducing mitochondrial apoptosis

Jie, Jing; Shi, Le; Yue, Shuohao; Wang, Mo; Zhang, Junlin

doi:10.21037/tcr-19-2076

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Bostrycin was also able to inhibit the growth of Mycobacterium tuberculosis in vitro and inhibit the activity of effector protein tyrosine phosphatase (MptpB) secreted by Mtb. In addition, bostrycin also acted as an antitumor agent against various cancer cell lines [206][207][208][209]. Both toxins showed a phytotoxic effect on water hyacinth at a concentration of 7 and 30 µg•mL −1 , respectively [128].…”

Section: Anthraquinone Derivativesmentioning

confidence: 99%

Recent Advances in Alternaria Phytotoxins: A Review of Their Occurrence, Structure, Bioactivity, and Biosynthesis

Wang

Guo

Luo

et al. 2022

JoF

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Alternaria is a ubiquitous fungal genus in many ecosystems, consisting of species and strains that can be saprophytic, endophytic, or pathogenic to plants or animals, including humans. Alternaria species can produce a variety of secondary metabolites (SMs), especially low molecular weight toxins. Based on the characteristics of host plant susceptibility or resistance to the toxin, Alternaria phytotoxins are classified into host-selective toxins (HSTs) and non-host-selective toxins (NHSTs). These Alternaria toxins exhibit a variety of biological activities such as phytotoxic, cytotoxic, and antimicrobial properties. Generally, HSTs are toxic to host plants and can cause severe economic losses. Some NHSTs such as alternariol, altenariol methyl-ether, and altertoxins also show high cytotoxic and mutagenic activities in the exposed human or other vertebrate species. Thus, Alternaria toxins are meaningful for drug and pesticide development. For example, AAL-toxin, maculosin, tentoxin, and tenuazonic acid have potential to be developed as bioherbicides due to their excellent herbicidal activity. Like altersolanol A, bostrycin, and brefeldin A, they exhibit anticancer activity, and ATX V shows high activity to inhibit the HIV-1 virus. This review focuses on the classification, chemical structure, occurrence, bioactivity, and biosynthesis of the major Alternaria phytotoxins, including 30 HSTs and 50 NHSTs discovered to date.

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Section: Anthraquinone Derivativesmentioning

confidence: 99%

Recent Advances in Alternaria Phytotoxins: A Review of Their Occurrence, Structure, Bioactivity, and Biosynthesis

Wang

Guo

Luo

et al. 2022

JoF

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“…Bostrycin is a classical compound isolated from marine fungi, and its antitumor activity has been demonstrated in prostate, gastric, and lung cancers ( Chen et al, 2011 ; Chen et al, 2012a ; Jie et al, 2020 ). It can significantly inhibit the proliferation of tumor cells, promote apoptosis, and cause cell cycle arrest in the G0/G1 phase ( Chen et al, 2011 ; Chen et al, 2012a ).…”

Section: Ncrnas As Oncogenes or Tumor Suppressors Involved In The Ant...mentioning

confidence: 99%

Non-coding RNA-related antitumor mechanisms of marine-derived agents

et al. 2022

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In the last two decades, natural active substances have attracted great attention in developing new antitumor drugs, especially in the marine environment. A series of marine-derived compounds or derivatives with potential antitumor effects have been discovered and developed, but their mechanisms of action are not well understood. Emerging studies have found that several tumor-related signaling pathways and molecules are involved in the antitumor mechanisms of marine-derived agents, including noncoding RNAs (ncRNAs). In this review, we provide an update on the regulation of marine-derived agents associated with ncRNAs on tumor cell proliferation, apoptosis, cell cycle, invasion, migration, drug sensitivity and resistance. Herein, we also describe recent advances in marine food-derived ncRNAs as antitumor agents that modulate cross-species gene expression. A better understanding of the antitumor mechanisms of marine-derived agents mediated, regulated, or sourced by ncRNAs will provide new biomarkers or targets for potential antitumor drugs from preclinical discovery and development to clinical application.

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