Non-coding RNA-related antitumor mechanisms of marine-derived agents

Abstract

In the last two decades, natural active substances have attracted great attention in developing new antitumor drugs, especially in the marine environment. A series of marine-derived compounds or derivatives with potential antitumor effects have been discovered and developed, but their mechanisms of action are not well understood. Emerging studies have found that several tumor-related signaling pathways and molecules are involved in the antitumor mechanisms of marine-derived agents, including noncoding RNAs (ncRNAs). In this review, we provide an update on the regulation of marine-derived agents associated with ncRNAs on tumor cell proliferation, apoptosis, cell cycle, invasion, migration, drug sensitivity and resistance. Herein, we also describe recent advances in marine food-derived ncRNAs as antitumor agents that modulate cross-species gene expression. A better understanding of the antitumor mechanisms of marine-derived agents mediated, regulated, or sourced by ncRNAs will provide new biomarkers or targets for potential antitumor drugs from preclinical discovery and development to clinical application.

Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

“…Regulatory ncRNAs are key players in almost all biological processes (12). Based on their structural features, ncRNAs are further categorized into microRNA (miRNA) (13), long non-coding RNA (lncRNA) (14), circular RNA (circRNA) (15), small interfering RNA (16), and PIWI-interacting RNA (17). They participate in the regulation of various biological processes, including transcription, development, and immunity, by altering specific gene expression (18)(19)(20).…”