Boron nitride nanotubes enhance properties of chitosan-based scaffolds

Emanet, Melis; Kazanc, Emine; Çobandede, Zehra; Çulha, Mustafa

doi:10.1016/j.carbpol.2016.05.074

Cited by 27 publications

(19 citation statements)

References 37 publications

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“…The e − pairs are more confined to N atoms owing to their high electronegativity in BN-based nanomaterials that strongly affect mechanical, optical, and electronic properties (Arenal and Lopez-Bezanilla, 2015;Jiang et al, 2015). Therefore, BN-based nanomaterials can improve thermal conductivity (Chang et al, 2005) and the mechanical (Sen and Çulha, 2015;Emanet et al, 2016) and antioxidant (Chen et al, 2004;Li et al, 2018) properties of several composites. High thermal conductivity and improved mechanical properties, including high tensile strength and elasticity, which BN-based nanomaterials can provide, are in high demand, for example for the construction of tissue-mimicking biomaterials used in transplantation (Jo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Functionalization, and Bioapplications of Two-Dimensional Boron Nitride Nanomaterials

Emanet

Şen

Taşkin

et al. 2019

Front. Bioeng. Biotechnol.

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Two-dimensional boron nitride nanostructures (2D-BNNs) have been increasingly investigated for their applications in several scientific and technological areas. This considerable interest is due to their unique physicochemical properties, which include high hydrophobicity, heat and electrical insulation, resistance to oxidation, antioxidation capacity, thermal conductivity, high chemical stability, mechanical strength, and hydrogen storage capacity. They are also used as fillers, antibacterial agents, protective coating agents, lubricants, boron neutron capture therapy agents, nanocarriers for drug delivery, and for the receptor phase in chemosensors. The investigations for their use in medicine and biomedicine are very promising, including cancer therapy and wound healing. In this review, 2D-BNNs synthesis and their surface modification strategies, biocompatibility, and bioapplication studies are discussed. Finally, a perspective for the future use of these novel nanomaterials in the biomedical field is provided.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Functionalization, and Bioapplications of Two-Dimensional Boron Nitride Nanomaterials

Emanet

Şen

Taşkin

et al. 2019

Front. Bioeng. Biotechnol.

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“…Hydroxylated BNNTs (BNNT-OH) were included into a chitosan scaffold and tested for their mechanical strength. The results of this study indicated that the inclusion of BNNT-OH increased mechanical strength and induced cell proliferation and adhesion decreased the scaffold degradation rate when compared to chitosan-only scaffold and did not cause toxicity to human dermal fibroblast cells [42]. Despite of some different experimental approaches and nanomaterial complexity, most of the studies show very good response of cells and organisms toward boron nitride nanocompounds.…”

Section: Boron Nitride Functionalization and Its Implications In Nanomentioning

confidence: 85%

“…The optical density of bacterial growth curves and the transmission electron microscopy morphology images revealed that PEI-BNNTs exhibit strong microbial activity against Escherichia coli and Staphylococcus aureus [41]. Because of its low toxicity, high mechanical strength, and chemical stability, BNNTs also are considered to be a promising bioactive material for bone tissue engineering, improving polymers, composites, and scaffold properties [42]. In a study, akermanite (AKM), a bioactive material, was reinforced with boron nitride nanosheets (BNNSs) to ameliorate its mechanical features [43].…”

Section: Boron Nitride Functionalization and Its Implications In Nanomentioning

confidence: 99%

Functionalized Boron Nitride Applications in Biotechnology

Ribeiro¹,

Randow²,

Vilela³

et al. 2020

Recent Advances in Boron-Containing Materials

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Due to its interesting chemical, physical, and biological properties, boron nitride has received considerable attention by the scientific and technological communities. However, there is a strong dependency of its structural quality and compatibility in different host systems, regarding its potential applications. The use of these different nanostructures involves several challenges due to their low dispersibility in water and organic solvents; thus, its chemical modification is an important step that gives them specificity. Therefore, the ability to control their surface (physically or chemically) is essential for exploring and building blocks in the nanoengineering of supramolecular structures. In this chapter, we report different boron nitride functionalization processes, as well as their important uses as adjuvants in vaccines, brachytherapy, or drug delivery. Besides some important theoretical studies that have demonstrated the different functionalization possibilities for use in nanomedicine, are also reported.

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“…In order to improve the mechanical properties of biomaterials and increase their biocompatibility, h-BN has been used in many studies as a biocomposite component [8,9,36,[48][49][50]59,60]. For example, in one study, it was demonstrated that some particular mechanical properties of HA were improved with the addition of boron nitride nanotubes, and it was reported that there was no negative effect on the viability and proliferation of osteoblast cells [9].…”

Section: Discussionmentioning

confidence: 99%

In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitride- chitosan-collagen biocomposite coating in rats

Deveci¹,

Gönenci²,

Canpolat³

et al. 2020

Turk J Vet Anim Sci

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The biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300-500 g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.

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Boron nitride nanotubes enhance properties of chitosan-based scaffolds

Cited by 27 publications

References 37 publications

Synthesis, Functionalization, and Bioapplications of Two-Dimensional Boron Nitride Nanomaterials

Synthesis, Functionalization, and Bioapplications of Two-Dimensional Boron Nitride Nanomaterials

Functionalized Boron Nitride Applications in Biotechnology

In vivo biocompatibility and fracture healing of hydroxyapatite-hexagonal boron nitride- chitosan-collagen biocomposite coating in rats

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