Functionalized Boron Nitride Applications in Biotechnology

Ribeiro, Hélio; Randow, Paula von Cardoso; Vilela, Diego N.; Luciano, Milene Adriane; Andrade, Lídia M.

doi:10.5772/intechopen.80849

Cited by 11 publications

(10 citation statements)

References 85 publications

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“…Even high accumulation of B atoms inside the cells have been shown by these nanoparticles but they have failure in the therapeutic window for BNCT. More improvements are still needed to design a 10 B-enriched BNNPs source [103,104].…”

Section: Boron Nitride Nanotubes/nanoparticles With Bnctmentioning

confidence: 99%

Boron Chemistry for Medical Applications

2020

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Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a new class for medicinal chemists to use in their drug designs. Carboranes are a class of organometallic compounds containing carbon (C), boron (B), and hydrogen (H) and are the most widely studied boron compounds in medicinal chemistry. Additionally, other boron-based compounds are of great interest, such as dodecaborate anions, metallacarboranes and metallaboranes. The boron neutron capture therapy (BNCT) has been utilized for cancer treatment from last decade, where chemotherapy and radiation have their own shortcomings. However, the improvement in the already existing (BPA and/or BSH) localized delivery agents or new tumor-targeted compounds are required before realizing the full clinical potential of BNCT. The work outlined in this short review addresses the advancements in boron containing compounds. Here, we have focused on the possible clinical implications of the new and improved boron-based biologically active compounds for BNCT that are reported to have in vivo and/or in vitro efficacy.

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Section: Boron Nitride Nanotubes/nanoparticles With Bnctmentioning

confidence: 99%

Boron Chemistry for Medical Applications

2020

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“…One of the major drawbacks of using pristine BNNTs in cell culture is the tendency to form agglomeration [81], which can affect both cell proliferation and biocompatibility evaluation [65,81]. Thus, the initial step to employ BNNTs in biological systems is to obtain the homogenous dispersion of BNNTs in aqueous media or in other physiological media [146,147]. To overcome this limitation, the functionalisation of the surface of BNNTs with various approaches such as covalent [148], noncovalent [149], defect reaction, and inner-space filling [150,151] were employed to give nanotubes a good dispersibility in water and biological mediums (Figure 3a).…”

Section: Bnnts Functionalisation Modification and Types Of Compositesmentioning

confidence: 99%

In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review

Kakarla

Kong

2022

Nanomaterials

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Boron nitride nanotubes (BNNTs) are an exciting class of nanomaterials due to their unique chemical and physical characteristics. In recent decades, BNNTs have gained huge attention in research and development for various applications, including as nano-fillers for composites, semiconductor devices, hydrogen storage, and as an emerging material in biomedical and tissue engineering applications. However, the toxicity of BNNTs is not clear, and the biocompatibility is not proven yet. In this review, the role of BNNTs in biocompatibility studies is assessed in terms of their characteristics: cell viability, proliferation, therapeutic outcomes, and genotoxicity, which are vital elements for their prospective use in biomedical applications. A systematic review was conducted utilising the databases Scopus and Web of Science (WOS) (2008–2022). Additional findings were discovered manually by snowballing the reference lists of appropriate reviews. Only English-language articles were included. Finally, the significant analysis and discussion of the chosen articles are presented.

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“…Just like carbon, it occurs in amorphous and crystalline forms. The major crystalline forms are hexagonal boron nitride (h-BN) compared to graphite, sphalerite boron nitride (β-BN) similar to cubic diamond, and rhombohedral (r-BN) and wurtzite boron nitride (γ-BN), which is in hexagonal diamond form [3,[8][9][10]. Boron nitride nanotubes (BNNT) are also known.…”

Section: General Information About Hexagonal Boron Nitride (H-bn)mentioning

confidence: 99%

Few-Layered Hexagonal Boron Nitride: Functionalization, Nanocomposites, and Physicochemical and Biological Properties

Jędrzejczak-Silicka¹,

Trukawka²,

Piotrowska³

et al. 2020

Biochemical Toxicology - Heavy Metals and Nanomaterials

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Hexagonal boron nitride (h-BN) is an analogue of graphite called "white graphene." In the structure of h-BN, B and N atoms substitute C atoms. The boron and nitrogen atoms are linked via strong B-N covalent bonds and form interlocking hexagonal rings. h-BN is used in different areas due to its interesting physical and chemical properties, e.g., in electronics as an insulator and in ceramics, resins, plastics, and paints. Therefore, boron nitride (BN) is also a popular inorganic compound in cosmetic industry (the highest BN concentration up to 25% can be found in eye shadow formulation). It is also widely used in dental cement production (for dental and orthodontic applications). Boron nitride seems to be suitable for biomedical applications; therefore, the cytotoxicity in vitro and in vivo observations of h-BN nanoplates and novel few-layered h-BN-based nanocomposites are still needed. The short-time studies confirm their low cytotoxicity and suggest that BN can be used as a novel drug delivery system; however, medical application needs additional verification in long-term studies.

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Functionalized Boron Nitride Applications in Biotechnology

Cited by 11 publications

References 85 publications

Boron Chemistry for Medical Applications

Boron Chemistry for Medical Applications

In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review

Few-Layered Hexagonal Boron Nitride: Functionalization, Nanocomposites, and Physicochemical and Biological Properties

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