2017
DOI: 10.1016/j.jocd.2017.06.020
|View full text |Cite
|
Sign up to set email alerts
|

Bone Turnover Markers: Use in Fracture Prediction

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
30
1

Year Published

2018
2018
2022
2022

Publication Types

Select...
6
2
1

Relationship

1
8

Authors

Journals

citations
Cited by 49 publications
(32 citation statements)
references
References 39 publications
1
30
1
Order By: Relevance
“…Patients with osteoporotic fractures were found to have higher average serum levels of PINP and β-CTX level as compared to that in patients with OP. The results were supported by published literature which suggested that subjects with fractures had higher bone turnover rate [ 32 34 ]. However, the difference described in the present study was not statistically significant.…”
Section: Discussionsupporting
confidence: 86%
“…Patients with osteoporotic fractures were found to have higher average serum levels of PINP and β-CTX level as compared to that in patients with OP. The results were supported by published literature which suggested that subjects with fractures had higher bone turnover rate [ 32 34 ]. However, the difference described in the present study was not statistically significant.…”
Section: Discussionsupporting
confidence: 86%
“…It would also be of interest to estimate the risk of fracture in the individual postmenopausal woman when deciding about the need for anti-resorptive treatment, and high bone turnover is associated with increased risk of several types of fracture in both men and women (7,13). In a recent meta-analysis of 6 studies that had measurements of bone resorption (CTX) and bone formation (PINP), the hazard ratio per SD increase was similar for CTX (1.18, 95% CI 1.05-1.34) and PINP (1.23, 95% CI 1.09-1.39) (14).…”
Section: Prediction Of Fracturementioning
confidence: 99%
“…BTMs have been shown to provide relevant information on the extent of bone resorption and bone formation. 27 In a position paper published by the IOF, the biomarker taskforce has recommended the use of CTx and PINP as reference markers for all clinical studies, adding one of these markers is sufficient for daily clinical practice measurements. 28 It is noteworthy that irrespective of BTMs being associated with an individual's fracture risk, such markers are currently not included in any available fracture risk assessment tool.…”
Section: Proteomic Parametersmentioning
confidence: 99%
“…Possible reasons are the considerable diurnal variability of such markers and the fact that their significance in men is less well investigated compared with women. 27 As a result, bone resorption markers including CTx and TRAP, as well as bone formation markers including OC, PINP and bALP will be measured in this study. A modelling algorithm (to be discussed later) will be applied to reduce the preanalytical variability.…”
Section: Proteomic Parametersmentioning
confidence: 99%