Bone Turnover Markers: Use in Fracture Prediction

Vilaça, Tatiane; Gossiel, Fatma; Eastell, Richard

doi:10.1016/j.jocd.2017.06.020

Cited by 49 publications

(32 citation statements)

References 39 publications

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“…Patients with osteoporotic fractures were found to have higher average serum levels of PINP and β-CTX level as compared to that in patients with OP. The results were supported by published literature which suggested that subjects with fractures had higher bone turnover rate [ 32 – 34 ]. However, the difference described in the present study was not statistically significant.…”

Section: Discussionsupporting

confidence: 86%

Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population

Wang

Sun

et al. 2018

Med Sci Monit

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BackgroundAdrenergic receptor α2A (α2A-AR) is up-regulated in osteoporotic bone osteoblasts. Previous research demonstrated an association between polymorphism of α2A-AR gene and bone mineral density (BMD) as well as bone turnover markers (BTMs) in the Slovenian population. The present study aimed to investigate the association of rs1800544 polymorphism of α2A-AR gene with BMD and BTMs in the Chinese elderly population with osteoporosis (OP) or with osteoporotic fractures.Material/MethodsA total of 346 unrelated elderly individuals were recruited in the study. Rs1800544 polymorphism was determined by Snapshot technology. BTMs were determined by electrochemiluminescence. BMDs at lumbar spine (LS) and proximal femur were measured with dual-energy X-ray absorptiometry (DEXA). Hardy-Weinberg equilibrium and distribution of genotype frequencies were verified using the chi-squared test. Analysis of co-variance (ANCOVA) adjusted for confounding factors was performed to explore the relationship of rs1800544 polymorphism with BMD and BTMs in all participants and in subgroups.ResultsThe genotype distributions in all subjects and in subgroups conformed to Hardy-Weinberg equilibrium (P>0.1). Distribution of genotype frequencies of subgroups showed no significant differences (P>0.05). Patients with GG genotype in the fracture group had significantly higher serum BTMs level compared with those carrying other genotypes (P<0.05). No significant association between rs1800544 and BTMs was detected in the elderly population with OP. Comparison of BMD at each site in all participants did not show any significant difference in subgroups with CC, CG, and GG genotypes (P>0.05).ConclusionsRs1800544 polymorphism is associated with BTMs level in Chinese elderly individuals with osteoporotic fractures, indicating the involvement of genetic variation of α2A-AR gene in bone metabolism.

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Section: Discussionsupporting

confidence: 86%

Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population

Wang

Sun

et al. 2018

Med Sci Monit

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“…It would also be of interest to estimate the risk of fracture in the individual postmenopausal woman when deciding about the need for anti-resorptive treatment, and high bone turnover is associated with increased risk of several types of fracture in both men and women (7,13). In a recent meta-analysis of 6 studies that had measurements of bone resorption (CTX) and bone formation (PINP), the hazard ratio per SD increase was similar for CTX (1.18, 95% CI 1.05-1.34) and PINP (1.23, 95% CI 1.09-1.39) (14).…”

Section: Prediction Of Fracturementioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: Bone turnover markers: are they clinically useful?

Eastell

Pigott

Gossiel

et al. 2018

European Journal of Endocrinology

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111

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Bone turnover markers (BTMs) are useful in clinical practice as they are inexpensive, and they have proven useful for treatment monitoring and identification of poor adherence. BTMs cannot be used in individual patients for identifying accelerated bone loss or an increase in fracture risk or in deciding on the optimal therapy. They are useful for monitoring both anti-resorptive and anabolic treatment. Response can be defined as a result that exceeds an absolute target, or by a change greater than the least significant change; if such a response is not present, then poor compliance or secondary osteoporosis are likely causes. A baseline BTM measurement is not always made; in that case, a value of BTM on anti-resorptive treatment that is low or low normal or above the reference interval for anabolic therapy may be taken to indicate a satisfactory response. We provide an approach to using these bone turnover markers in clinical practice by describing algorithms for anti-resorptive and anabolic therapy and describing the changes we observe in the clinical practice setting.

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“…BTMs have been shown to provide relevant information on the extent of bone resorption and bone formation. 27 In a position paper published by the IOF, the biomarker taskforce has recommended the use of CTx and PINP as reference markers for all clinical studies, adding one of these markers is sufficient for daily clinical practice measurements. 28 It is noteworthy that irrespective of BTMs being associated with an individual's fracture risk, such markers are currently not included in any available fracture risk assessment tool.…”

Section: Proteomic Parametersmentioning

confidence: 99%

“…Possible reasons are the considerable diurnal variability of such markers and the fact that their significance in men is less well investigated compared with women. 27 As a result, bone resorption markers including CTx and TRAP, as well as bone formation markers including OC, PINP and bALP will be measured in this study. A modelling algorithm (to be discussed later) will be applied to reduce the preanalytical variability.…”

Section: Proteomic Parametersmentioning

confidence: 99%

Protocol for a multicentre, prospective cohort study of clinical, proteomic and genomic patterns associated with osteoporosis to develop a multidimensional fracture assessment tool: the PoCOsteo Study

et al. 2020

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IntroductionThe HORIZON 2020 project PoCOsteo aims (1) to develop a multidimensional fracture risk assessment tool which would take into account all factors known to be related to an individual’s fracture risk. The fracture risk model is intended to be developed in two different populations, namely a European and a Middle Eastern one; (2) to develop a medical device, which would measure and/or quantify proteomic as well as genomic factors as present in whole blood samples collected through finger prick; (3) to test the clinical applicability and the validity of prototypes of the to be developed point of care device at both clinical centres.Methods and analysisThis article presents the protocol of this prospective cohort that will be carried out independently at two different centres (Division of Endocrinology and Diabetology at the Medical University of Graz (MUG) as a clinic-based cohort, and Endocrinology and Metabolism Research Institute (EMRI) at the Tehran University of Medical Sciences (TUMS) as a population-based cohort). The final aim is to develop a fracture risk assessment model, which would include clinical risk factors, biochemical markers of bone turnover, as well as specific genomic factors. The derivation cohorts will consist of individuals aged 50 years and above. The period of observation for each patient will be 12 months; an extension phase, which would last for another 2 years, is also planned.Ethics and disseminationThese studies are conducted in accordance with the World Medical Association Declaration of Helsinki. The Iranian part was approved by the Research Ethics Committee of EMRI, TUMS. The Austrian part was approved by the Ethics Committee of the Medical University of Graz. Based on the gathered information, a multidimensional fracture assessment tool will be designed which will later be added to the PoCOsteo device.

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Bone Turnover Markers: Use in Fracture Prediction

Cited by 49 publications

References 39 publications

Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population

Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population

DIAGNOSIS OF ENDOCRINE DISEASE: Bone turnover markers: are they clinically useful?

Protocol for a multicentre, prospective cohort study of clinical, proteomic and genomic patterns associated with osteoporosis to develop a multidimensional fracture assessment tool: the PoCOsteo Study

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