Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population

Wang, Qifei; Sun, Zhe; F, Zheng; Zhang, Guangwu; Liu, Zheng

doi:10.12659/msm.908376

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The chi-squared test was used to evaluate the Hardy-Weinberg equilibrium or allele frequencies of all SNPs [ 23 , 24 ]. Unconditional logistic regression was conducted to calculate the adjusted odds ratio (OR) and 95% confidence intervals (95% CI).…”

Section: Methodsmentioning

confidence: 99%

The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation

Zhu

Qian

et al. 2022

BMC Cardiovasc Disord

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Background This study aimed to analyze associations between genetic variants and plasma concentrations along with clinical outcomes in dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods We conducted a prospective study and enrolled NVAF patients treated with dabigatran in the real world. A total of 86 patients treated with 110 mg DE twice daily were recruited for this study. Blood samples were obtained from each patient and used for genotyping and determination of plasma dabigatran concentration. All bleeding and thromboembolic complications were recorded during the 1.5 years of follow-up. Results Eighty-three patients provided samples at the trough plasma level of dabigatran, and 58 patients provided samples at the peak plasma level of dabigatran. There was a significant association between the CES1 SNP rs8192935 and trough plasma concentrations of dabigatran (P = 0.013). Our results showed that the CES1 SNP rs8192935 significantly influenced dabigatran trough concentrations in the Chinese population, and carriers of the G allele had increased trough plasma concentrations of dabigatran compared to noncarriers. The ABCB1 SNP c.2482-2236G > A (rs4148738) was associated with major bleeding events in the addictive model (P = 0.046, OR = 3.29) and dominant model (P = 0.040, OR = 8.17). Additionally, the ABCB1 SNP c.3435 C > T (rs1045642) was associated with the incidence of major bleeding events in the addictive model (P = 0.043, OR = 3.34) and dominant model (P = 0.046, OR = 7.77). However, no significant associations were found between all the SNPs and the incidence of minor bleeding events. Conclusion Our results indicated that the CES1 polymorphism rs8192935 was associated with trough plasma concentrations of dabigatran. Carriers of the G allele had increased trough plasma concentrations of dabigatran compared to noncarriers. The ABCB1 polymorphisms rs4148738 and rs1045642 were associated with an increased risk for major bleeding events for the first time in a Chinese population.

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Section: Methodsmentioning

confidence: 99%

The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation

Zhu

Qian

et al. 2022

BMC Cardiovasc Disord

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“…ARs consist of two subtypes, αARs and βARs. Both osteoblasts [ 92 ] and osteoclasts [ 93 ] express αAR. βARs may be the main AR that regulates the effects of sympathetic nerves on bone remodeling.…”

Section: Crosstalk Between Bone and Brainmentioning

confidence: 99%

Crosstalk between bone and other organs

Yuan

Song

2022

Medical Review

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Bone has long been considered as a silent organ that provides a reservoir of calcium and phosphorus, traditionally. Recently, further study of bone has revealed additional functions as an endocrine organ connecting systemic organs of the whole body. Communication between bone and other organs participates in most physiological and pathological events and is responsible for the maintenance of homeostasis. Here, we present an overview of the crosstalk between bone and other organs. Furthermore, we describe the factors mediating the crosstalk and review the mechanisms in the development of potential associated diseases. These connections shed new light on the pathogenesis of systemic diseases and provide novel potential targets for the treatment of systemic diseases.

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Unraveling the Unexplored Complexity of Osteoporosis: Deciphering Targeted Therapeutic Strategies Through Integrated Bioinformatics Analysis of Single-Cell Rna Sequencing, Differential Mirna Expression, and Drug Interactions

Du,

Chang,

Xue

et al. 2023

Preprint

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Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population

Cited by 3 publications

References 34 publications

The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation

The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation

Crosstalk between bone and other organs

Unraveling the Unexplored Complexity of Osteoporosis: Deciphering Targeted Therapeutic Strategies Through Integrated Bioinformatics Analysis of Single-Cell Rna Sequencing, Differential Mirna Expression, and Drug Interactions

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