Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review

Haimov, Haim; Yosupov, Natali; Pinchasov, Ginnady; Juodžbalys, Gintaras

doi:10.5037/jomr.2017.8201

Cited by 33 publications

(21 citation statements)

References 40 publications

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“…In recent years, different types of coating have been introduced for clinical use: natural, peptide, ceramic, and synthetic coatings (Civantos et al, 2017). Most have been designed with osteointegration (Civantos et al, 2017;Haimov et al, 2017) and antibacterial purposes (Zhao et al, 2009;Swartjes et al, 2015;Kulkarni Aranya et al, 2017). To date, antibacterial, biodegradable perioperative coatings are designed to be loaded with gentamicin or vancomycin (Romanò et al, 2015) and are already on the market.…”

Section: Discussionmentioning

confidence: 99%

A New Antibiotic-Loaded Sol-Gel Can Prevent Bacterial Prosthetic Joint Infection: From in vitro Studies to an in vivo Model

et al. 2020

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The aim of this study was to evaluate the effect of a moxifloxacin-loaded organicinorganic sol-gel with different antibiotic concentration in the in vitro biofilm development and treatment against Staphylococcus aureus, S. epidermidis, and Escherichia coli, cytotoxicity and cell proliferation of MC3T3-E1 osteoblasts; and its efficacy in preventing the prosthetic joint infection (PJI) caused by clinical strains of S. aureus and E. coli using an in vivo murine model. Three bacterial strains, S. epidermidis ATCC 35984, S. aureus 15981, and, E. coli ATCC 25922, were used for microbiological studies. Biofilm formation was induced using tryptic-soy supplemented with glucose for 24 h, and then, adhered and planktonic bacteria were estimated using drop plate method and absorbance, respectively. A 24-h-mature biofilm of each species growth in a 96well plate was treated for 24 h using a MBECTM biofilm Incubator lid with pegs coated with the different types of sol-gel, after incubation, biofilm viability was estimated using alamrBlue. MC3T3-E1 cellular cytotoxicity and proliferation were evaluated using CytoTox 96 Non-Radioactive Cytotoxicity Assay and alamarBlue, respectively. The microbiological studies showed that sol-gel coatings inhibited the biofilm development and treated to a mature biofilm of three evaluated bacterial species. The cell studies showed that the sol-gel both with and without moxifloxacin were non-cytotoxic and that cell proliferation was inversely proportional to the antibiotic concentration containing by sol-gel. In the in vivo study, mice weight increased over time, except in the E. coliinfected group without coating. The most frequent symptoms associated with infection were limping and piloerection; these symptoms were more frequent in infected groups

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Section: Discussionmentioning

confidence: 99%

A New Antibiotic-Loaded Sol-Gel Can Prevent Bacterial Prosthetic Joint Infection: From in vitro Studies to an in vivo Model

et al. 2020

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“…Protein adsorption is known to be affected by various surface properties, such as roughness, organic impurities, chemical composition, van der Waals interactions, and hydrogen bonding [ 29 , 30 ]. Although many reports have described protein coating treatments of implant surfaces in the last decade, most titanium surface treatments require a period of several hours to several days [ 31 , 32 , 33 ]. However, in the present study, we performed UV pre-treatment and BMP-2 treatment for 1 min or UV pre-treatment and FN treatment for 1 h on the titanium surface for a short period of time using a simple method.…”

Section: Discussionmentioning

confidence: 99%

UV-Pre-Treated and Protein-Adsorbed Titanium Implants Exhibit Enhanced Osteoconductivity

Sugita

Saruta

Taniyama

et al. 2020

IJMS

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Titanium materials are essential treatment modalities in the medical field and serve as a tissue engineering scaffold and coating material for medical devices. Thus, there is a significant demand to improve the bioactivity of titanium for therapeutic and experimental purposes. We showed that ultraviolet light (UV)-pre-treatment changed the protein-adsorption ability and subsequent osteoconductivity of titanium. Fibronectin (FN) adsorption on UV-treated titanium was 20% and 30% greater after 1-min and 1-h incubation, respectively, than that of control titanium. After 3-h incubation, FN adsorption on UV-treated titanium remained 30% higher than that on the control. Osteoblasts were cultured on titanium disks after 1-h FN adsorption with or without UV-pre-treatment and on titanium disks without FN adsorption. The number of attached osteoblasts during the early stage of culture was 80% greater on UV-treated and FN-adsorbed (UV/FN) titanium than on FN-adsorbed (FN) titanium; osteoblasts attachment on UV/FN titanium was 2.6- and 2.1-fold greater than that on control- and UV-treated titanium, respectively. The alkaline phosphatase activity of osteoblasts on UV/FN titanium was increased 1.8-, 1.8-, and 2.4-fold compared with that on FN-adsorbed, UV-treated, and control titanium, respectively. The UV/FN implants exhibited 25% and 150% greater in vivo biomechanical strength of bone integration than the FN- and control implants, respectively. Bone morphogenetic protein-2 (BMP-2) adsorption on UV-treated titanium was 4.5-fold greater than that on control titanium after 1-min incubation, resulting in a 4-fold increase in osteoblast attachment. Thus, UV-pre-treatment of titanium accelerated its protein adsorptivity and osteoconductivity, providing a novel strategy for enhancing its bioactivity.

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“…Our research team has also demonstrated that the aminogroups can be uniformly deposited on a Ti surface to bind with albumin using the promising lowtemperature plasma polymerization with allylamine approach [34]. It was found that the presence of reactive functional groups on the Ti surface significantly affects the reaction between the cell and bone tissue [35,36]. The formation of this feature can be attributed to the rapid absorption of biomolecules, mainly after the Ti implant surface is exposed to blood.…”

Section: Biocompatibility Evaluationmentioning

confidence: 94%

Preparation of a Biofunctionalized Surface on Titanium for Biomedical Applications: Surface Properties, Wettability Variations, and Biocompatibility Characteristics

Huang

et al. 2020

Applied Sciences

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This study developed a promising approach (low-temperature plasma polymerization with allylamine) to modify the titanium (Ti) surface, which helps the damaged tissue to heal faster. The Ti surface was first cleaned by argon (Ar) plasma, and then the functional amino-groups were coated on the Ti surface via plasma polymerization. The topography characteristics, wettability, and optimal plasma modification parameters were investigated through atomic force spectroscopy, secondary ion mass spectroscopy, and response surface methodology (RSM). Analytical results showed that the formation of a porous surface was found on the Ar plasma-modified Ti surfaces after Ar plasma modification with different parameters. The Ar plasma modification is an effective approach to remove surface contaminants and generate a porous topography on the Ti surface. As the Ti with Ar plasma modification was at 100 W and 190 m Torr for 12 min, the surface exhibited the maximum hydrophilic performance. In the allylamine plasma modifications, the contact angle values of the allylamine plasma-modified Ti surfaces varied between 70.15° and 88.26° in the designed parameters. The maximum concentration of amino-groups (31.58 nmole/cm2) can be obtained from the plasma-polymerized sample at 80 W and 150 mTorr for 22 min. Moreover, the cell response also demonstrated that the allylamine plasma-modified Ti sample with an optimal modification parameter (80 W, 22 min, and 150 mTorr) possessed great potential to increase cell adhesion ability. Thus, the optimal parameters of the low-temperature plasma polymerization with allylamine can be harvested using the RSM design. These data could provide new scientific information in the surface modification of Ti implant.

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Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review

Cited by 33 publications

References 40 publications

A New Antibiotic-Loaded Sol-Gel Can Prevent Bacterial Prosthetic Joint Infection: From in vitro Studies to an in vivo Model

A New Antibiotic-Loaded Sol-Gel Can Prevent Bacterial Prosthetic Joint Infection: From in vitro Studies to an in vivo Model

UV-Pre-Treated and Protein-Adsorbed Titanium Implants Exhibit Enhanced Osteoconductivity

Preparation of a Biofunctionalized Surface on Titanium for Biomedical Applications: Surface Properties, Wettability Variations, and Biocompatibility Characteristics

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