Preparation of a Biofunctionalized Surface on Titanium for Biomedical Applications: Surface Properties, Wettability Variations, and Biocompatibility Characteristics

Abstract

This study developed a promising approach (low-temperature plasma polymerization with allylamine) to modify the titanium (Ti) surface, which helps the damaged tissue to heal faster. The Ti surface was first cleaned by argon (Ar) plasma, and then the functional amino-groups were coated on the Ti surface via plasma polymerization. The topography characteristics, wettability, and optimal plasma modification parameters were investigated through atomic force spectroscopy, secondary ion mass spectroscopy, and response surface methodology (RSM). Analytical results showed that the formation of a porous surface was found on the Ar plasma-modified Ti surfaces after Ar plasma modification with different parameters. The Ar plasma modification is an effective approach to remove surface contaminants and generate a porous topography on the Ti surface. As the Ti with Ar plasma modification was at 100 W and 190 m Torr for 12 min, the surface exhibited the maximum hydrophilic performance. In the allylamine plasma modifications, the contact angle values of the allylamine plasma-modified Ti surfaces varied between 70.15° and 88.26° in the designed parameters. The maximum concentration of amino-groups (31.58 nmole/cm2) can be obtained from the plasma-polymerized sample at 80 W and 150 mTorr for 22 min. Moreover, the cell response also demonstrated that the allylamine plasma-modified Ti sample with an optimal modification parameter (80 W, 22 min, and 150 mTorr) possessed great potential to increase cell adhesion ability. Thus, the optimal parameters of the low-temperature plasma polymerization with allylamine can be harvested using the RSM design. These data could provide new scientific information in the surface modification of Ti implant.

Coated Surface on Ti-30Ta Alloy for Biomedical Application: Mechanical and in-vitro Characterization

“…In biomedical applications, lower hydrophilicity or increased hydrophobicity is required for improved cellular interaction. Previous studies have related the surface energy of a biomaterial with cellular functionality such as protein adsorption, platelet adhesion and activation leading to blood coagulation, and bacterial adhesion 17,[26][27][28][29][30] .Thus, in this study, the hydrophilic behavior of Group 1 -Nanotubes of TiO 2 and Group 2 -Nanotubes of TiO 2 covered with PCL were investigated by measuring their respective contact angles (See Figure 4).…”

Surface properties of micro surface patterned Cp-Ti alloy via electrical discharge machining

“…To be biocompatible, the surfaces of materials must be hydrophilic (wettable) and rough (to ensure cell adhesion) [12,13]. Additionally, it is desirable for titanium alloys to have hydrophobic surfaces [14]. Using micro/nano surface patterning techniques, it is possible to modify biocompatibility, protein adsorption, and cell/surface interactions [15,16].…”