Bone mineral density in patients with familial Mediterranean fever

Yıldırım, Kadir; Karatay, Saliha; Çetinkaya, Ramazan; Uzkeser, Hülya; Erdal, Akın; Capoglu, Ilyas; Erdem, Fazile Hatipoğlu

doi:10.1007/s00296-009-0950-3

Cited by 23 publications

(17 citation statements)

References 17 publications

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“…In patients with rheumatoid arthritis, elevated acute-phase reactants have been correlated with lower BMD and higher bone turnover [19]. A statistically significant difference in ESR and CRP between patients with familial Mediterranean fever and controls has also been observed [20]. Osteoclastic bone resorption in those diseases was associated with increased production of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

et al. 2011

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SummaryAim. In ankylosing spondylitis (AS) inflammatory activity probably plays a key role in the pathophysiology of bone loss. The aim of the study was to investigate the relationship of bone mineral density (BMD) at the lumbar spine and hip region with some measures of disease activity and functional ability in patients with ankylosing spondylitis.Methods: In 80 patients with established ankylosing spondylitis disease activity and functional ability were determined by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Spinal pain and patient global health were assessed using horizontal visual analogue scale (VAS). BMD was measured by dual-energy x-ray absorptiometry (DXA).Results. There was a significant negative correlation of bone density T scores with acute phase reactants (i.e. patients with lower T scores had higher level of CRP and ESR). That relationship was reflected more reliably at proximal femur sites than at the lumbar spine.There were also significant differences in ESR, BASDAI, BASFI, spinal pain and global health between three groups of patients according to WHO classification of osteoporosis (normal, osteopenic and osteoporotic). Significantly more patients with osteopenia at the lumbar spine had lower BASDAI index than those with normal BMD (p=0.030). Conclusion:Our results indicate an association of low BMD with high disease activity in patients with AS. Femoral BMD seems to be more associated with disease activity and functional ability than lumbar spine BMD.

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Section: Discussionmentioning

confidence: 99%

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

et al. 2011

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“…FMF is characterized by recurrent episodes of painful inflammation in the abdomen, chest or joints, and these inflammatory attacks have not yet been clearly explained [16][17][18]. One of the factors involved in the inflammatory attacks of FMF is oxidative stress [8].…”

Section: Discussionmentioning

confidence: 99%

Trace Element Levels in Patients with Familial Mediterranean Fever

Yıldırım

Uzkeser

Uyanik

et al. 2011

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Objective: Although the genetic etiology of familial Mediterranean fever (FMF) is known, limited information is available regarding the regulation of inflammation during attack-free periods. The aim of this study was to determine the alterations in serum copper (Cu), zinc (Zn) and selenium (Se) levels that may be associated with inflammation during attack-free periods in FMF patients. Materials and Methods:This study included 33 patients with FMF and 30 healthy volunteers. Erythrocyte sedimentation rate (ESR), the serum C-reactive protein (CRP) level and serum levels of Cu, Zn and Se in FMF patients and healthy volunteers were assessed by the atomic absorption spectrophotometry method.Results: ESR and serum CRP levels and serum Cu and Zn levels were similar between patients with FMF during an attack-free period and healthy controls (p>0.05). Serum Se levels in the patient group were significantly higher than in the control group (p<0.05). Conclusion:Our study shows that levels of trace elements in serum are variable in patients with FMF during attack-free periods. Serum Se concentrations may at least in part contribute to the subclinical inflammation in FMF patients during attack-free periods. However, further studies are necessary to confirm this result. Sonuç: Bizim çalışmamız ataksız dönemdeki FMF hastalarında serumdaki eser element seviyelerinin değişken olabildiğini göster-mektedir. Serum Se konsantrasyonları FMF hastalarında en azından ataksız dönemdeki subklinik inflamasyona katkıda bulunabilir. Bu sonuçları değerlendirmek için yeni çalışmalara ihtiyaç bulunmaktadır.

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“…On the other hand, Suyani et al [8] reported that lumbar BMD and T score, femoral neck BMD and T score and total femur BMD in 35 patients with FMF were not diVerent from that of the controls, but total femur T score was signiWcantly lower than that of the controls. Yildirim et al [6] found lower BMD values both in lumbar and proximal femur in 28 patients with FMF compared to the controls especially Table 4 Comparison of the demographic and laboratory parameters between the groups with positive and negative family history for FMF (median (minimum-maximum)) FMF familial Mediterranean fever, BMI body mass index, ESR erythrocyte sedimentation rate, CRP C-reactive protein and BMD bone mineral density a P < 0.05 is signiWcant b The data expressed as mean ( §standard deviation) c The data expressed as number (%) in the lumbar region. It is seen that there are variations in the regions of bone loss in these studies.…”

Section: Discussionmentioning

confidence: 99%

“…It is seen that there are variations in the regions of bone loss in these studies. Yildirim et al [6] tried to explain the marked decrease in lumbar BMD than the proximal femur by the increased loss of trabecular bone in osteoporosis. On the other hand, it is not possible to explain the regional diVerences of bone loss observed in patients with FMF considering Suyani et al's [8] study as there was only cortical bone loss.…”

Section: Discussionmentioning

confidence: 99%

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Bone mineral density in familial Mediterranean fever

et al. 2011

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The aim of this study was to evaluate the bone mineral density (BMD) in familial Mediterranean fever (FMF) and to search the effects of genetic factors, family history of FMF and types of clinical attacks on BMD. Forty-four attack-free patients with FMF and 36 healthy voluntary subjects were included in the study. BMD measurements of lumbar spine and left proximal femur were performed by dual energy X-ray absorptiometry (DEXA). There was no statistically significant difference between patient and control groups regarding median values of lumbar BMD (P = 0.06), lumbar T (P = 0.08) and Z (P = 0.12) scores, femoral neck BMD (P = 0.13), femoral T (P = 0.22) and Z (P = 0.16) scores and total femur BMD (P = 0.14), T (P = 0.19) and Z (P = 0.27) scores. Patients with negative FMF family history had significantly lower femoral neck BMD (P = 0.018), femoral neck T (P = 0.009) and Z (P = 0.01) scores and total femur BMD (P = 0.033) than patients with positive FMF family history. There was no significant difference among the groups regarding mutation characteristic and types of attacks in lumbar BMD, T and Z scores, femoral neck BMD, T and Z scores and total femur BMD, T and Z scores (P > 0.05). We found that the bone loss of patients with FMF is not different from that of the controls. The increased bone loss in the patients with negative family history for FMF should be further investigated with larger patient groups taking into consideration of the risk factors related to family history for osteoporosis.

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Bone mineral density in patients with familial Mediterranean fever

Cited by 23 publications

References 17 publications

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

Trace Element Levels in Patients with Familial Mediterranean Fever

Bone mineral density in familial Mediterranean fever

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