Trace Element Levels in Patients with Familial Mediterranean Fever

Yıldırım, Kadir; Uzkeser, Hülya; Uyanik, Abdullah; Karatay, Saliha; Kızıltunç, Ahmet

doi:10.5152/eajm.2011.18

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Exposure to TCDD also induced a significant suppression in the activities of antioxidant enzymes, such as SOD, CAT, and GSH-Px in the liver. SOD is the primary step of the defense mechanism in the antioxidant system against oxidative stress (Yildirim et al, 2011). It catalyses the dismutation of two superoxide radicals (O 2 À ) into molecular oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ; Kakarla et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver

et al. 2012

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic damage. Propolis exhibits antioxidant properties and several studies suggest that supplementations with antioxidants can influence hepatotoxicity. Therefore, the aim of the current study was to explore the effectiveness of propolis in alleviating the toxicity of TCDD in the liver of rats. Animals were divided into six groups, namely, TCDD (0.75 and 8 µg/kg body weight (bw)), propolis (50 mg/kg bw), TCDD (0.75 and 8 µg) plus propolis (50 mg/kg bw), and control, respectively. Rats were intraperitoneally administered with their respective doses daily for 21 days. In rats that received a high dose of TCDD, the antioxidant enzymes were significantly decreased and the serious pathological findings were established. Also, the rate of hepatocyte micronucleus (HMN) was increased after treating with TCDD. The reactions of enzymes in control and low-dose group were weak. The frequencies of HMN and liver histology were similar to both the groups. The presence of propolis with TCDD alleviated its pathological effects in hepatic tissue. Propolis also prevented the suppression of antioxidant enzymes in the livers of animals exposed to TCDD and displayed a strong protective effect against HMN. It can be concluded that propolis has beneficial influences and was able to antagonize TCDD toxicity in the liver.

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Section: Discussionmentioning

confidence: 99%

Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver

et al. 2012

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“…Oxidative stress is involved in the onset of several disorders after TCDD exposure. Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to humans against infectious and degenerative diseases (Nader et al, 2010;Yildirim et al, 2011). Thus, there is an increasing interest in finding the appropriate agents with antioxidative protection for hepatocytes (Ciftci et al, 2011;Turkez et al, 2011bTurkez et al, , 2011cTurkez et al, , 2012Yin et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Beneficial effect of astaxanthin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury in rats

2012

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Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) represents a potential health risk and hepatotoxicity. Astaxanthin (ASTA) exhibits antioxidant properties and can influence hepatotoxicity. Therefore, the present study was carried out for using ASTA against hepatotoxicity induced by TCDD in the liver of rats. Animals were treated intraperitoneally daily with TCDD (8 µg/kg body weight (b.w.)), ASTA (12.5 mg/kg b.w. and 25 mg/kg b.w.) and TCDD plus ASTA (12.5 and 25 mg/kg b.w.) for 21 days. TCDD significantly decreased the activities of antioxidant enzymes and resulted in serious pathological findings. Moreover, the rate of micronucleus (MN) in hepatocytes increased after treating with TCDD. The activities of enzymes, frequencies of MNs and liver histology in lower dosage group of ASTA remained unchanged compared with the control group. In rats treated with ASTA, at higher dosage alone, the MNs remained unchanged and the activities of antioxidant enzymes significantly increased. The presence of ASTA (except for lower dose) with TCDD alleviated its pathological effects in hepatic tissue. ASTA also prevented the suppression of antioxidant enzymes in the livers of animals exposed to TCDD and displayed a strong protective effect against MNs. Thus, the present findings might provide new insight into the development of therapeutic and preventive approaches of TCDD toxicity.

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“…FMF is an autosomal recessive disorder that characterized by the exacerbations and remissions (16). Duration and frequency are not presumable.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum interleukin-1β levelsand acute phase response proteins in patients with familial Mediterranean fever

et al. 2012

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Introduction: The aim of this study was to investigate whether serum levels of interleukin-1β (IL-1β) has any possible correlation on infl ammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fi brinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period. Materials and methods:The serum levels of IL-1β, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fi brinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers. Results: Serum IL-1β levels were signifi cantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically signifi cant diff erence in the serum levels of ESR, CRP and fi brinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a signifi cant correlation between IL-1β and CRP (r = 0.513, P = 0.002) values of FMF group. Conclusions: In conclusion, our results confi rm the presence of increased IL-1β levels in FMF patients during attack-free period. Serum IL-1β values seems to correlate with CRP levels. The elevation of IL-1β levels may be important in monitoring subclinical infl ammation of attack free period in FMF patients.

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Trace Element Levels in Patients with Familial Mediterranean Fever

Cited by 4 publications

References 31 publications

Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver

Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver

Beneficial effect of astaxanthin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury in rats

Relationship between serum interleukin-1β levelsand acute phase response proteins in patients with familial Mediterranean fever

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