Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

Grazio, Simeon; Kusić, Zvonko; Cvijetić, Selma; Grubišić, Frane; Balenović, Antonija; Nemčić, Tomislav; Matijević-Mikelić, Valentina; Punda, Marija; Sieper, Joachim

doi:10.1007/s00296-011-2066-9

Cited by 31 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bone marrow edema in AS patients is related to inflammation, which leads to increased water in extracellular spaces and may indicate that the increase of disease activity states causes an increase in the diffusion of local water molecules, resulting in higher ADC mean values . Previous studies have reported that low bone marrow density is correlated with high disease activity in AS patients with increased ADC values, which is in agreement with our results …”

Section: Discussionsupporting

confidence: 92%

Whole‐lesion ADC histogram analysis and the spondyloarthritis research consortium of canada (SPARCC) MRI index in evaluating the disease activity of ankylosing spondylitis

Wang

Chu

Zhu

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Conventional MRI is limited in quantitative evaluation of ankylosing spondylitis (AS) activity states. A comparison of the effectiveness of the whole‐lesion apparent diffusion coefficient (ADC) histogram analysis with the Spondyloarthritis Research Consortium of Canada (SPARCC) MRI index in evaluating the disease activity of AS might aid in this assessment. Purpose To compare the effectiveness of the whole‐lesion ADC histogram analysis with the SPARCC MRI index in evaluating the disease activity states of AS. Study Type Prospective. Population A total of 57 AS patients and 27 healthy matched volunteers were included. Field Strength/Sequence 3.0T MR including a diffusion‐weighted imaging (DWI) sequence (b = 0, 1000 s/mm2). Statistical Tests One‐way analysis of variance (ANOVA) and Scheffe's post‐hoc was used to compare the parameters among different groups. A receiver operating characteristic (ROC) analysis and the Spearman rank correlation were performed to test the diagnostic performance of all parameters in distinguishing different disease activity states and determining the correlations between them. Assessment AS disease activity states was evaluated according to the Ankylosing Spondylitis Disease Activity Score (ASDAS). Initial DWI images and corresponding ADC maps were imported into our in‐house software. Regions of interest (ROIs) were drawn in all slices and the relevant parameters were derived simultaneously. The SPARCC MRI index scores were counted artificially based on T2‐PDW‐SPAIR images. Results The ADCmean, ADC percentiles, and SPARCC MRI index of the active group were significantly higher than the inactive and control groups (all P < 0.001). The 90th percentile could differentiate the inactive from the control group and the low disease activity group from the inactive group (P = 0.011 and 0.006, respectively). The 50th percentile of the high disease activity group was significantly higher than the low group (P = 0.004), while the SPARCC MRI index of the very high disease activity group was higher than the high group (P < 0.001). Data Conclusion The whole‐volume ADC histogram analysis was superior to the SPARCC MRI index in assessing AS activity states. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:114–126.

show abstract

Section: Discussionsupporting

confidence: 92%

Whole‐lesion ADC histogram analysis and the spondyloarthritis research consortium of canada (SPARCC) MRI index in evaluating the disease activity of ankylosing spondylitis

Wang

Chu

Zhu

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Perhaps, BMD measurement at the FN is not affected by the syndesmophytes and ectopic calcifications that frequently occur in the LS [36,37]. Previous studies obtained similar findings and showed that anteroposterior lumbar DXA results could be misleading when evaluating the extent of OP and treating late-stage-AS patients [38,39]. Table 1 for definitions a Significant difference from the control group b Significant difference from the normal BMD group c Significant difference from the osteopenia group Table 3 Correlations between BMD T-scores, Table 1 for definitions Results are presented as the coefficient of correlation.…”

Section: Discussionsupporting

confidence: 67%

The Relationship of Bone Mineral Density to Oxidant/Antioxidant Status and Inflammatory and Bone Turnover Markers in a Multicenter Cross-Sectional Study of Young Men with Ankylosing Spondylitis

et al. 2015

View full text Add to dashboard Cite

Low bone mineral density (BMD) is an important complication of ankylosing spondylitis (AS) that seriously affects men and their quality of life, even in young patients. However, the relationships among redox; levels of bone turnover markers (BTMs), inflammatory markers and disease activity; and low BMD in AS require clarification. We recruited 102 men aged 30-39 year with AS and 102 healthy, sex- and age-matched controls for this cross-sectional study. The subjects were analyzed for lumbar spine and femoral neck BMD by dual-energy X-ray absorptiometry. Significantly lower BMD and corresponding T-scores were observed in the AS patients compared with the controls (P < 0.05). The oxidant biomarker and antioxidant levels were significantly (P < 0.05) higher and lower, respectively, in the AS subjects compared with the controls, and the bone resorption and inflammatory marker levels were higher (P < 0.05). In subgroup analyses, the patients with osteoporosis or active disease had the highest levels of oxidant biomarkers (P < 0.05). Furthermore, the BMD T-scores in AS were found to be negatively correlated with oxidative status (P < 0.05). Multivariate binary logistic analysis showed that low BMD in the AS patients was associated with higher levels of advanced oxidation protein products, malondialdehyde and C-terminal telopeptide of type I collagen; lower levels of glutathione peroxidase; and higher scores of a bath ankylosing spondylitis metrology index. In conclusion, imbalanced redox was independently associated with low BMD in young men with AS and may play an important role in the pathogenesis of AS-related low BMD.

show abstract

“…erosions) and new bone formation, the latter being the main radiological characteristic of ankylosing spondylitis [35,36]. In spite of bony growth in ankylosing spondylitis osteoporosis of the lumbar spine was found in up to 34.3% and osteoporosis of the hip in up to 29% patients [37][38][39][40][41][42]. Moreover, Capaci et al found that even 61.6% of patients with mild AS had spinal osteoporosis and osteopenia, while 46.6% had osteoporosis and osteopenia at the total hip [43].…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

Self Cite

View full text Add to dashboard Cite

Aims: Although considered as a feature of inflammatory rheumatic diseases, there is a lot of controversy around low bone mass in patients with psoriatic arthritis. The aim of this cross-sectional study was to analyze bone mineral density in patients with psoriatic arthritis, as well as to investigate its possible association with some measures of disease activity and functional capacity. Subjects and Methods:Sixty-nine patients with established psoriatic arthritis (mean age 56.20±12.23 years) and who has not been treated with specific antiosteoporotic drugs were recruited from the outpatient clinic database. Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and at the left hip. Disease activity measures included: duration of morning stiffness, tender and swollen joint count, patient's and physician's global assessment, presence of dactylitis and enthesitis, ESR, CRP and Disease Activity Score 28. Health Assessment Questionnaire was used to assess functional status.Results: According to WHO definition, spinal osteoporosis was found in 7.2% of patients, total hip osteoporosis in 1.4% of patients and femoral neck osteoporosis in 2.9% of patients. There was no significant association of any of the measures of disease activity with BMD at any site. Higher HAQ scores were associated with lower total hip BMD.Conclusions: In our sample of patients with psoriatic arthritis we did not find increased prevalence of osteoporosis. There was no association of BMD with indices of disease activity, while negative correlation was found between HAQ and total hip BMD.

show abstract

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

Cited by 31 publications

References 30 publications

Whole‐lesion ADC histogram analysis and the spondyloarthritis research consortium of canada (SPARCC) MRI index in evaluating the disease activity of ankylosing spondylitis

Whole‐lesion ADC histogram analysis and the spondyloarthritis research consortium of canada (SPARCC) MRI index in evaluating the disease activity of ankylosing spondylitis

The Relationship of Bone Mineral Density to Oxidant/Antioxidant Status and Inflammatory and Bone Turnover Markers in a Multicenter Cross-Sectional Study of Young Men with Ankylosing Spondylitis

Osteoporosis in psoriatic arthritis: Is there any?

Contact Info

Product

Resources

About