Bone mineral density in patients with Beh�et?s disease

Biçer, Ali; Türsen, Ümit; Kaya, Tamer İrfan; Özer, Caner; Ankaralı, Handan; İkizoğlu, Güliz; Erdoğan, Canan

doi:10.1007/s00296-003-0381-5

Cited by 13 publications

(22 citation statements)

References 11 publications

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“…Bicer et al found and reported no significant differences between control and BD patients. 2 Kirnap et al reported significant difference in bone mineral density, T score and scores of L2-L4, but not in other region. 3 We found significant difference in all regions of BMD measurements except L2-L4 vertebra BMD.…”

Section: Discussionmentioning

confidence: 99%

“…1 In several studies, it was shown that bone involvement, particularly osteoporosis and osteopenia, is commonly developed in BD due to natural course of disease and agents used for its treatment. 2,3 Osteoporosis is considered to be an imbalance of the remodeling process, in which bone resorption exceeds bone formation. A growing understanding of this process has shown that factors involved in inflammation are linked to critical factors associated with bone physiology.…”

Section: Introductionmentioning

confidence: 99%

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Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Kutlucan¹,

Tunc²,

Baltaci³

et al. 2012

Dicle Med J

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ÖZETAmaç: Behçet hastalığı (BH)'nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH'nda osteoprotegerin ve tümor nekroz faktör (TNF-α) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem:Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-α, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.26±11.64 ve 41.66±70.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-α (p<0.001), deokspiridinolin (p<0.001) ve osteokalsin (p=0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p>0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grubunda kontrol grubuna göre anlamlı yüksekti (p=0.03). Hasta grubun KMD ölçümü; L2-L4 hariç, kontrol grubuna göre anlamlı oranda düşüktü (sırasıyla p<0.001, p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 ve p=0.111). TNF-α ve osteoprotegerin arasında korelasyon saptanmadı.Sonuç: Bu çalışmada TNF-α ve KMD arasında negatif korelasyon saptandı ve TNF-α'nın, BH'da osteoporotik süreci etkilediği bulundu. Osteoprotogerin düzeyi düşük-lüğü anlamlı değildi ve TNF-α ile korele değildi.Anahtar kelimeler: Behçet hastalığı, osteoprotegerin, TNF-α, osteokalsin ABSTRACT Objectives: Osteoporosis is commonly developed due to natural course of Behçet's disease (BD) and therapeutic agents. It was aimed to investigate levels of osteoprotegerin and TNF-α (tumor necrosis factor), and bone mineral density (BMD) and correlation between them in BD. Materials and methods:The study included two groups as the study and the control group. Serum levels of TNF-α, osteoprotegerin, osteocalcine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and urinary creatinine and deoxypyridinoline along with BMD level were evaluated and compared. Correlation between TNF-α and osteoprotegerin level was investigated. Results:The study enrolled 41 BD patients and 36 agedmatched control subjects. Mean age was 42.26±11.64 and 41.66±70.99, in the study and control groups, respectively. There was no significant difference in body mass index (BMI) of subjects between groups (p>0.05). Level of TNF-α (p<0.001), deoxypyridinoline (p<0.001) and osteocalcine (p=0.041) was significantly higher in the study group compared to the control group. Osteoprotegerin was lower in BD patients, but the difference was not significant (p>0.05). Urinary deoxypyridinoline/ urinary creatinine ratio in patients with BD was significantly higher than those in control group (p=0.030). Patients had significantly lower BMD comparfed to the control group, except L2-L4 vertebral area (p<0.001, p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 and p=0.111, respectively). No correla...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Kutlucan¹,

Tunc²,

Baltaci³

et al. 2012

Dicle Med J

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“…The chronicity and vasculitic background of the disease and the drugs for the treatment of BD suggest that bone metabolism might be affected negatively, which then leads to bone loss, resulting in osteoporosis in patients with BD [8]. Osteoporosis is a common disease characterized by a systemic impairment of bone mass and microarchitecture that causes fragility fractures [39].…”

Section: Bone Metabolismmentioning

confidence: 99%

“…There are limited numbers of clinical trial that reveal the status of bone metabolism and bone mineral density (BMD) in the medical literature, and findings in these investigations are in consistent [8, 19, 46]. First, the status of BMD was investigated in a study, where BMD measurements of lumbar spine and hip in BD showed similar results when compared to those in healthy subjects [8].…”

Section: Bone Metabolismmentioning

confidence: 99%

“…Furthermore, it was also claimed that the disease could be classified into the spondyloarthropathy (SpA) complex, because of the presence of sacroiliitis in BD and the clinical overlap between BD and some disease of the SpA complex [7]. On the other hand, the chronicity and factors involved in inflammatory process of the disease and the drugs used for the treatment of BD might have negative effects on bone remodeling, consequently resulting in osteoporosis in BD [8]. …”

Section: Introductionmentioning

confidence: 99%

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Musculoskeletal Findings in Behcet's Disease

Biçer

2012

Pathology Research International

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Behcet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Rheumatologic manifestations may also occur in Behcet's disease, and arthritis and arthralgia are the most common musculoskeletal findings followed by enthesopathy, avascular necrosis, myalgia, and myositis. Although the main pathology of Behcet's disease has been known to be the underlying vasculitis, the etiology and exact pathogenesis of the disease are still unclear. Musculoskeletal findings of Behcet's disease, the relationship between Behcet's disease and spondyloarthropathy disease complex, and the status of bone metabolism in patients with Behcet's disease were discussed in this paper.

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Bone mineral density in patients with familial Mediterranean fever

et al. 2009

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This study was carried out to determine lumbar and femoral bone mineral density (BMD) in patients with familial Mediterranean fever (FMF), an autosomal-recessive disease characterized by recurrent episodes of peritonitis, pleuritis, and arthritis, which are usually associated with fever. In patients with FMF and control subjects, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured. BMD was determined at the lumbar spine (L1-4) and the femoral regions (neck and total) using dual energy X-ray absorptiometry. Twenty-eight FMF patients and 30 control subjects without a history of inflammatory disease participated in our study. The demographic variables, such as age, sex and body mass index were similar between patients and controls (P > 0.05). We found statistically significant difference in ESR and CRP between FMF patients and controls (P < 0.01, P < 0.05 respectively). There was statistically significant difference in lumbar spine, femoral neck, and total femur BMD between FMF patients and control groups (P < 0.001, P < 0.01, P < 0.01 respectively).Our study indicates that lumbar spine and femoral neck and total femur BMD in patients with FMF may be lower than in healthy subjects.

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Bone mineral density in patients with Beh�et?s disease

Cited by 13 publications

References 11 publications

Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Musculoskeletal Findings in Behcet's Disease

Bone mineral density in patients with familial Mediterranean fever

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