Bone marrow necrosis related to paracoccidioidomycosis: the first eight cases identified at autopsy

Resende, Lucilene Silva Ruiz e; Mendes, Rinaldo Pôncio; Bacchi, Mírian Rumenos Piedade; Marques, Sílvio Alencar; Barraviera, Benedito; Souza, L. R.; Meira, Domingos Alves; Niéro-Melo, Lígia

doi:10.1111/j.1365-2559.2009.03245.x

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…32,33 Acute-sub acute forms may occur in urban patients, with no history of living or staying in the rural zone, which can delay the diagnosis; also these patients must be investigated for a possible co-infection by HIV, because the have an atypical epidemiologic profile. 34,35 Monocyte-macrophage system tropism in the acute-sub acute forms includes the Payer's patches in the intestinal wall, as well as intra and extra-peritoneal lymph nodes; the latter may become abscessed and thus infect the psoas muscle on one or both sides, evolving slowly, gravely and difficult to diagnose.…”

Section: Clinical Presentationmentioning

confidence: 99%

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Marques¹

2013

An. Bras. Dermatol.

114

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Paracoccidioidomycosis is an acute - to chronic systemic mycosis caused by fungi of the genus Paracoccidioides. Due to its frequent tegument clinical expression, paracoccidioidomycosis is an important disease for dermatologists, who must be up-to-date about it. This article focuses on recent epidemiological data and discusses the new insights coming from molecular studies, as well as those related to clinical, diagnostic and therapeutic aspects. In the latter section, we give particular attention to the guideline on paracoccidioidomycosis organized by specialists in this subject.

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Section: Clinical Presentationmentioning

confidence: 99%

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Marques¹

2013

An. Bras. Dermatol.

114

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“…The epidermis in skin lesions shows pseudoepitheliomatous hyperplasia. In the bone marrow there may be coagulative necrosis with osteonecrosis (129).…”

Section: Diseases Caused By Other Fungi and Organisms Resembling Fungmentioning

confidence: 99%

Histopathologic Diagnosis of Fungal Infections in the 21st Century

2011

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SUMMARY Fungal infections are becoming more frequent because of expansion of at-risk populations and the use of treatment modalities that permit longer survival of these patients. Because histopathologic examination of tissues detects fungal invasion of tissues and vessels as well as the host reaction to the fungus, it is and will remain an important tool to define the diagnostic significance of positive culture isolates or results from PCR testing. However, there are very few instances where the morphological characteristics of fungi are specific. Therefore, histopathologic diagnosis should be primarily descriptive of the fungus and should include the presence or absence of tissue invasion and the host reaction to the infection. The pathology report should also include a comment stating the most frequent fungi associated with that morphology as well as other possible fungi and parasites that should be considered in the differential diagnosis. Alternate techniques have been used to determine the specific agent present in the histopathologic specimen, including immunohistochemistry, in situ hybridization, and PCR. In addition, techniques such as laser microdissection will be useful to detect the now more frequently recognized dual fungal infections and the local environment in which this phenomenon occurs.

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“…Cases of subacute PCM were reported by Fonseca et al [36] among children in the city of Belém, Pará State, Brazil, showing that the most frequent symptoms were superficial lymph node enlargement (in 100 % of cases), fever (in 92.3 %), weight loss (in 84.6 %), and increased abdominal volume (in 46 %). Other rare manifestations such as bone marrow necrosis can be seen in acute/subacute PCM, as described by Resende et al [37] in a report of eight patients who were autopsied at Botucatu University Hospital. The most remarkable immunological aspect of acute/subacute PCM is depression of the cell-mediated response, which is important for disease control and leads to the worst prognosis, with high lethality [38].…”

Section: The Acute/subacute Formmentioning

confidence: 72%

Epidemiology, Clinical, and Therapeutic Aspects of Paracoccidioidomycosis

Costa

Silva²

2014

Curr Trop Med Rep

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Paracoccidioidomycosis, or PCM, was described by Adolfo Lutz 105 years ago. Since then the disease has taken a prominent position among the systemic fungal infections because it mainly affects individuals in the most productive years of their lives in various countries of Latin America. In Brazil, the disease is considered endemic in some regions. However, it is still a neglected disease. With the recent discovery that Paracoccidioides brasiliensis is not the only species of this genus, numerous studies have contributed to better understanding and recognition of this pathogen and its pathology in many aspects, such as the epidemiological, clinical, and therapeutic aspects.

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Bone marrow necrosis related to paracoccidioidomycosis: the first eight cases identified at autopsy

Cited by 12 publications

References 15 publications

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Histopathologic Diagnosis of Fungal Infections in the 21st Century

Epidemiology, Clinical, and Therapeutic Aspects of Paracoccidioidomycosis

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