Bone-like apatite coating on functionalized poly(etheretherketone) surface via tailored silanization layers technique

Zheng, Yanyan; Xiong, Chengdong; Zhang, Shenglan; Li, Xiaoyu; Zhang, Lifang

doi:10.1016/j.msec.2015.05.070

Cited by 62 publications

(46 citation statements)

References 40 publications

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“…It was reported by Chen et al that -COOH groups introduced onto polylactide scaffolds by alkaline erosion, significantly enhanced mineralization of the scaffold surface [57]. Reports from other authors also proved that functionalized with -COOH groups poly(etheretherketone) surface [54], polylactide electrospun fibers [56] as well as chitin and gellan gum hydrogels [58] promote the deposition of apatite on its surface in When a scaffold is implanted, some processes as dissolution, ion exchange and precipitation occur on its surface. The ion release to the surroundings is important to the new bone tissue formation, where a calcium deposition on the extracellular matrix around the implanted scaffold takes place [59].…”

Section: In Vitro Degradation and Bioactivity Of Prepared Materialsmentioning

confidence: 93%

“…The negatively charged groups, such as -COOH, -OH, have a greater induction capability for the heterogeneous nucleation and growth of apatite, while positive charged groups e.g. -NH 2 , exhibit a weaker nucleating ability [53][54][55][56]. The induction period required for the apatite nucleation depends on the kind, number and arrangement of the functional groups [55].…”

Section: In Vitro Degradation and Bioactivity Of Prepared Materialsmentioning

confidence: 99%

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Novel crosslinkable polyester resin–based composites as injectable bioactive scaffolds

Śmiga-Matuszowicz

Łukaszczyk

Pilawka

et al. 2016

International Journal of Polymeric Materials and Polymeric Biom

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In this study new composite materials obtained by crosslinking two polyester resins were investigated. The solid composite material and the scaffolds with varied porosity were obtained in the presence of a foaming system consisted of calcium carbonate/citric acid mixture. It was found that the presence of citric acid solution influenced rheological behaviour of liquid formulations as well as morphology and mechanical properties of cured materials. SEM observations and analysis by energy X-ray dispersive spectroscopy confirmed the presence of hydroxyapatite formed at the scaffolds surfaces in phosphate buffer solution. The MTS cytotoxicity assay was carried out for extracts from selected composite materials using the human osteosarcoma cells (SaOS-2).

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Section: In Vitro Degradation and Bioactivity Of Prepared Materialsmentioning

confidence: 93%

Section: In Vitro Degradation and Bioactivity Of Prepared Materialsmentioning

confidence: 99%

Novel crosslinkable polyester resin–based composites as injectable bioactive scaffolds

Śmiga-Matuszowicz

Łukaszczyk

Pilawka

et al. 2016

International Journal of Polymeric Materials and Polymeric Biom

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“…However, the deposition of apatite minerals to polymeric materials at the micro and nanoscale remains a challenge. They represent organic phase materials and inorganic phase materials, respectively, which results in poor physical bonding . Moreover, loosely attached nano‐HAP (nHAP) particles may migrate from the implant site into surrounding tissues, which may provoke activation of macrophages and cause damage to healthy tissues .…”

Section: Introductionmentioning

confidence: 99%

Biomineralization improves mechanical and osteogenic properties of multilayer‐modified PLGA porous scaffolds

Kong

Wei

Groth

et al. 2018

J Biomedical Materials Res

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Poly-(lactide-co-glycolide acid) (PLGA) has been widely investigated as scaffold material for bone tissue engineering owing to its biosafety, biodegradability, and biocompatibility. However, the bioinert surface of PLGA may fail in regulating cellular behavior and directing osteointegration between the scaffold and the host tissue. In this article, oxidized chondroitin sulfate (oCS) and type I collagen (Col I) were assembled onto PLGA surface via layer by layer technique (LbL) as an adhesive coating for the attachment of inorganic minerals. The multilayer-modified PLGA scaffold was mineralized in vitro to ensure the deposition of nanohydroxyapatite (nHAP). It was found that nHAP crystals were more uniformly and firmly attached on the multilayer-modified PLGA as compared with the pure PLGA scaffold, which remarkably improved PLGA surface and mechanical properties. Additionally, in vitro biocompatibility of PLGA scaffold, in terms of bone mesenchymal stem cells (BMSCs) attachment, spreading and proliferation was greatly enhanced by nHAP coating and multilayer deposition. Furthermore, the fabricated composite scaffold also shows the ability to promote the osteogenic differentiation of BMSCs through the up-regulation of osteogenic marker genes. Thus, this novel biomimetic composite scaffold might achieve a desirable therapeutic result for bone tissue regeneration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2714-2725, 2018.

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“…[18][19][20] However, PEEK is bioinert and shows limited ability to bind to natural bone tissue. 21,22 Hydroxyapatite (HAP) has good biocompatibility and biodegradability and can form a strong bone bonding with bone tissue. [23][24][25] It is predicted that the addition of HAP to PEEK can improve the biological properties of scaffolds for bone tissue engineering application.…”

mentioning

confidence: 99%

“…21,22 Hydroxyapatite (HAP) has good biocompatibility and biodegradability and can form a strong bone bonding with bone tissue. [23][24][25] It is predicted that the addition of HAP to PEEK can improve the biological properties of scaffolds for bone tissue engineering application. However, the introduction of HAP into PEEK matrix will decrease the mechanical strength of scaffolds, especially in highly porous structure.…”

mentioning

confidence: 99%

A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds

Feng¹,

Peng

et al. 2016

IJN

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A nano-sandwich construct was built by combining two-dimensional graphene nanosheets (GNSs) and one-dimensional carbon nanotubes (CNTs) to improve the mechanical properties of hydroxyapatite–polyetheretherketone (HAP–PEEK) scaffolds for bone tissue engineering. In this nano-sandwich construct, the long tubular CNTs penetrated the interlayers of graphene and prevented their aggregation, increasing the effective contact area between the construct and matrix. The combination of GNSs and CNTs in a weight ratio of 2:8 facilitated the dispersion of each other and provided a synergetic effect in enhancing the mechanical properties. The compressive strength and modulus of the scaffolds were increased by 63.58% and 56.54% at this time compared with those of HAP–PEEK scaffolds, respectively. The carbon-based fillers, pulling out and bridging, were also clearly observed in the matrix. Moreover, the dangling of CNTs and their entangling with GNSs further reinforced the mechanical properties. Furthermore, apatite layer formed on the scaffold surface after immersing in simulated body fluid, and the cells attached and spread well on the surface of the scaffolds and displayed good viability, proliferation, and differentiation. These evidence indicate that the HAP–PEEK scaffolds enhanced by GNSs and CNTs are a promising alternative for bone tissue engineering.

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Bone-like apatite coating on functionalized poly(etheretherketone) surface via tailored silanization layers technique

Cited by 62 publications

References 40 publications

Novel crosslinkable polyester resin–based composites as injectable bioactive scaffolds

Novel crosslinkable polyester resin–based composites as injectable bioactive scaffolds

Biomineralization improves mechanical and osteogenic properties of multilayer‐modified PLGA porous scaffolds

A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds

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Bone-like apatite coating on functionalized poly(etheretherketone) surface via tailored silanization layers technique

Cited by 62 publications

References 40 publications

Novel crosslinkable polyester resin–based composites as injectable bioactive scaffolds

Novel crosslinkable polyester resin–based composites as injectable bioactive scaffolds

Biomineralization improves mechanical and osteogenic properties of multilayer‐modified PLGA porous scaffolds

A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite&ndash;polyetheretherketone scaffolds

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A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds