Novel crosslinkable polyester resin–based composites as injectable bioactive scaffolds

Abstract

In this study new composite materials obtained by crosslinking two polyester resins were investigated. The solid composite material and the scaffolds with varied porosity were obtained in the presence of a foaming system consisted of calcium carbonate/citric acid mixture. It was found that the presence of citric acid solution influenced rheological behaviour of liquid formulations as well as morphology and mechanical properties of cured materials. SEM observations and analysis by energy X-ray dispersive spectroscopy confirmed the presence of hydroxyapatite formed at the scaffolds surfaces in phosphate buffer solution. The MTS cytotoxicity assay was carried out for extracts from selected composite materials using the human osteosarcoma cells (SaOS-2).

Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials

“…For extending its range of applications, current approaches focus on mixing PPF with other polymers 8 or various nanofillers 9 which improve the mechanical properties. In addition, PPF is often mixed with inorganic materials including hydroxyapatite 10 , calcium carbonate or calcium sulfate 11 , β-tricalcium phosphate 12 and titania 13 . Several other studies report the incorporation of carbonaceous nanostructures such as carbon nanotubes, functionalized graphene oxide, graphene oxide nanoribbons or nanoplatelets, and fullerenes in PPF-based nanocomposite materials 8,9,14–16 .…”

Lysine-derived, pH-sensitive and biodegradable poly(beta-aminoester urethane) networks and their local drug delivery behaviour

“…[1][2][3][4] Numerous polymeric biomaterials containing hydrolyzable bonds to achieve biodegradability have been developed to date including poly(ε-caprolactone), poly(lactic-co-glycolide), poly(propylene fumarate), poly(ethylene glycol) and poly(beta-aminoester). [5][6][7][8] Among them, a considerable amount of literature has been published on poly(beta-aminoester) (PBAE) polymers that are completely biodegradable due to the hydrolysis of their ester bonds. 9,10 In particular, degradable networks of these PBAE polymers that can be obtained with PBAEs having acrylate end groups, are highly attractive since their properties can be tuned by changing the diacrylate/amine molecules and their ratio to influence crosslinking density, hydrophilicity and degradation time.…”