Bone healing with an in situ–formed bioresorbable polyethylene glycol hydrogel membrane in rabbit calvarial defects

Humber, Craig C.; Sándor, George K.B.; Davis, Joel M.; Peel, Sean; Brković, Božidar; Kim, Yong Deok; Holmes, Howard I.; Clokie, Cameron M. L.

doi:10.1016/j.tripleo.2009.10.008

Cited by 40 publications

(33 citation statements)

References 33 publications

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“…Similar to our observations, the barrier membrane did not prevent bone formation which occurred principally by intramembranous ossification from the peripheral edges of the defect. Membranes made from biocompatible materials that produce a limited host inflammation response have been tested successfully as GBR barriers in the rabbit calvarial defect model . In contrast to those materials, the SAPAE used in the present study actively suppressed the host inflammation response while still allowing bone formation.…”

Section: Discussionsupporting

confidence: 58%

Development of a guided bone regeneration device using salicylic acid‐poly(anhydride‐ester) polymers and osteoconductive scaffolds

Mitchell

Kim²,

Cottrell

et al. 2013

J Biomedical Materials Res

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Successful repair of craniofacial and periodontal tissue defects ideally involves a combined therapy that includes inflammation modulation, control of soft tissue infiltration, and bone regeneration. In this study, an anti-inflammatory polymer, salicylic acid-based poly(anhydride-ester) (SAPAE) and a three-dimensional osteoconductive ceramic scaffold were evaluated as a combined guided bone regeneration (GBR) system for concurrent control of inflammation, soft tissue ingrowth, and bone repair in a rabbit cranial defect model. At time periods of 1, 3, and 8 weeks, five groups were compared: (1) scaffolds with a solid ceramic cap (as a GBR structure); (2) scaffolds with no cap; (3) scaffolds with a poly(lactide-glycolide) cap; (4) scaffolds with a slow release SAPAE polymer cap; and (5) scaffolds with a fast release SAPAE polymer cap. Cellular infiltration and bone formation in these scaffolds were evaluated to assess inflammation and bone repair capacity of the test groups. The SAPAE polymers suppressed inflammation and displayed no deleterious effect on bone formation. Additional work is warranted to optimize the anti-inflammatory action of the SAPAE, GBR suppression of soft tissue infiltration, and stimulation of bone formation in the scaffolds and create a composite device for successful repair of craniofacial and periodontal tissue defects.

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Section: Discussionsupporting

confidence: 58%

Development of a guided bone regeneration device using salicylic acid‐poly(anhydride‐ester) polymers and osteoconductive scaffolds

Mitchell

Kim²,

Cottrell

et al. 2013

J Biomedical Materials Res

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“…Several researchers have reported the use of glycopolymers as emerging and promising materials for cell/tissue engineering . Thus, investigating the effects of synthetic glycopolymers on cellular functions of cells will provide a new direction for functionalizing surfaces of implant materials such as poly(ethylene glycol) (PEG)/poly(ethylene oxide) (PEO)‐based materials, metals, etc., with various glycomoieties …”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of poly(ethylene oxide)-based glycopolymers and their biocompatibility with osteoblast cells

et al. 2014

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“…There has been considerable discussion regarding the critical defect size at which natural healing does not occur in the rabbit calvarial defect model [28][29][30][31] . Hokugo et al 32) reported that natural healing did not occur with 5 mm diameter cranial defects.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Porous Hydroxyapatite Granule and Gelatin Hydrogel Microsphere Composite in Bone Regeneration

Yokota

Matsuno

Tabata

et al. 2017

J. Hard Tissue Biology.

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The purpose of this study was to investigate the property of hydroxyapatite (HA)/gelatin hydrogel (GH) composite granules as a scaffold and controlled-release carrier of basic fibroblast growth factor (bFGF) for bone regeneration. HA granules and GH microsphere at various weight ratios to the HA granules were mixed. The composite provided the controlled release of bFGF in vitro. The critical-sized bone defects of 6 mm diameter were created in the skull of New Zealand white rabbits and the composite granules with or without incorporated bFGF, were implanted into the defects. Bone regeneration and were evaluated by computed tomography and H-E staining. The composite granules incorporating bFGF promoted significantly higher bone regeneration at the defect site as compared to the bFGF-free composites. Further, the amount of new bone increased in proportion to the amount of GH microspheres incorporated into the composite. We conclude that the bFGF-impregnated HA/GH composite granules is useful for bone regeneration.

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Bone healing with an in situ–formed bioresorbable polyethylene glycol hydrogel membrane in rabbit calvarial defects

Cited by 40 publications

References 33 publications

Development of a guided bone regeneration device using salicylic acid‐poly(anhydride‐ester) polymers and osteoconductive scaffolds

Development of a guided bone regeneration device using salicylic acid‐poly(anhydride‐ester) polymers and osteoconductive scaffolds

Synthesis and characterization of poly(ethylene oxide)-based glycopolymers and their biocompatibility with osteoblast cells

Evaluation of a Porous Hydroxyapatite Granule and Gelatin Hydrogel Microsphere Composite in Bone Regeneration

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