Synthesis and characterization of poly(ethylene oxide)-based glycopolymers and their biocompatibility with osteoblast cells

Abstract

Poly(ethylene oxide)-block-poly(methacryl-D-glucopyranoside) (PEO-GP) and poly(methacryl-D-glucopyranoside) (H-GP

Synthesis of homo/3‐ and 4‐armed hydrophilic glycopolymers: To promote aniline to polyaniline‐glycopolymers for fluorescence, electro active material, and electrostatic discharge applications

“…Preparation of P(MTAGP) was carried using our earlier report. 30 That is, MTAGP monomer (5 g;0.012 mol) and 15.0 mL of dry 1,4-dioxane solvent were placed into a 50 mL schlock flask fitted with rubber septa and cleansed with nitrogen for 20 min. A total of 0.276 g of HMTETA (0.0012 mol) and 0.117 g of EBrIB homopolymer initiator (0.0006 mol) were added to the monomer solution through micro syringe and then the mixture was degassed with nitrogen for 10 min to remove air.…”

“…The product was isolated using the procedure reported earlier. 30 This procedure was adopted for the synthesis of 3-and 4-armed glycopolymer architectures [3-armed P(MTAGP) and 4-armed Figure S4). 13 Figure S5).…”

“…Methacryl-2,3,4,6-tetra-O-acetyl-D-glucopyranoside (MTAGP) was prepared, and the formation of the product was authenticated by 1 H NMR, 13 C NMR, and FT-IR according to a published protocol. 30 3-Armed Initiator: 2-[(2-bromo-2-methylpropanoyloxy) methyl]-2-Ethylpropane-1,3-Diyl Bis(2-bromo-2-methylpropanoate) Initiator. A total of 100 mL THF was taken in a 250 mL round bottomed flask and added trimethylolpropane (TMP) (5.0 g;0.0379 mol) and Et 3 N (23.78 g; 0.235 mol).…”

Sucrose Methacrylate-Based Amphiphilic Block Copolymers

“…For example, atom transfer radical polymerization (ATRP) was used to synthesize water‐soluble copolymers based on the unprotected glycomonomer 2‐{[( d ‐glucosamin‐2‐N‐yl)carbonyl]oxy}ethyl and butyl acrylate that present the capability to self‐assemble in water and to interact with lectin. ATRP was also used for poly(ethylene oxide)‐ block ‐poly(methacryl‐ d ‐glucopyranoside) synthesis . This copolymer is also water soluble, amorphous, and presents osteoblast cell adhesion.…”

“…This copolymer is also water soluble, amorphous, and presents osteoblast cell adhesion. Both ATRP‐synthesized copolymers showed a low molar mass dispersity ( Đ M ) and typical controlled polymerization kinetics . Reversible addition–fragmentation chain transfer polymerization (RAFT) was used to synthesize poly(acryloyl glucosamine) (PAGA), a block copolymer PAGA‐ b ‐P( N ‐isopropylacrylamide) and a three‐arm PAGA star‐like structure .…”