Evaluation of a Porous Hydroxyapatite Granule and Gelatin Hydrogel Microsphere Composite in Bone Regeneration

Yokota, Kensho; Matsuno, Tomonori; Tabata, Yasuhiko; Mataga, Izumi

doi:10.2485/jhtb.26.203

Cited by 3 publications

(2 citation statements)

References 34 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Биокомпозитный материал на основе желатина и β-TCP продемонстрировал улучшенную биоразлагаемость под воздействием коллагеназы при большем количестве желатина и высокую остеоиндуктивность, выраженную в повышении уровня активности щелочной фосфатазы in vitro [108].…”

Section: композитные матриксы из природных полимеровunclassified

New-generation osteoplastic materials based on biological and synthetic matrices

Lykoshin

Зайцев

Костромина

et al. 2021

Fine Chem. Technol.

View full text Add to dashboard Cite

Objectives. The purpose of this analytical review is to evaluate the market for osteoplastic materials and surgical implants, as well as study the features of new-generation materials and the results of clinical applications.Methods. This review summarizes the volumes of research articles presented in the electronic database PubMed and eLIBRARY. A total of 129 scientific articles related to biological systems, calcium phosphate, polymer, and biocomposite matrices as carriers of pharmaceutical substances, primary recombinant protein osteoinductors, antibiotics, and biologically active chemical reagents were analyzed and summarized. The search depth was 10 years.Results. Demineralized bone matrix constitutes 26% of all types of osteoplastic matrices used globally in surgical osteology, which includes neurosurgery, traumatology and orthopedics, dentistry, and maxillofacial and pediatric surgery. Among the matrices, polymer and biocomposite matrices are outstanding. Special attention is paid to the possibility of immobilizing osteogenic factors and target pharmaceutical substances on the scaffold material to achieve controlled and prolonged release at the site of surgical implantation. Polymeric and biocomposite materials can retard the release of pharmaceutical substances at the implantation site, promoting a decrease in the toxicity and an improvement in the therapeutic effect. The use of composite scaffolds of different compositions in vivo results in high osteogenesis, promotes the initialization of biomineralization, and enables the tuning of the degradation rate of the material.Conclusions. Osteoplastic materials of various compositions in combination with drugs showed accelerated regeneration and mineralization of bone tissue in vivo, excluding systemic side reactions. Furthermore, although some materials have already been registered as commercial drugs, a plethora of unresolved problems remain. Due to the limited clinical studies of materials for use on humans, there is still an insufficient understanding of the toxicity of materials, time of their resorption, speed of drug delivery, and the possible long-term adverse effects of using implants of different compositions.

show abstract

Section: композитные матриксы из природных полимеровunclassified

New-generation osteoplastic materials based on biological and synthetic matrices

Lykoshin

Зайцев

Костромина

et al. 2021

Fine Chem. Technol.

View full text Add to dashboard Cite

show abstract

“…However, bFGF has an extremely short half-life in vivo (more than 80% of the bFGF injected subcutaneously was eliminated from the injected site within 24 hours [10]). We therefore focused on gelatin hydrogel as a representative drug delivery system [11]. This carrier allows controlled release of incorporated growth factors over a long period of time [12–14].…”

Section: Introductionmentioning

confidence: 99%

Prevention of tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaws with basic fibroblast growth factor: An experimental study in rats

et al. 2019

Self Cite

View full text Add to dashboard Cite

Osteonecrosis of the jaw induced by administration of bisphosphonates (BPs), BP-related osteonecrosis (BRONJ), typically develops after tooth extraction and is medically challenging. As BPs inhibit oral mucosal cell growth, we hypothesized that suppression of the wound healing-inhibiting effects could prevent BRONJ onset after tooth extraction. Since basic fibroblast growth factor (bFGF) promotes wound healing, but has a short half-life, we examined whether the initiation of BRONJ could be prevented by applying a bFGF-containing gelatin hydrogel over the extraction sockets of BRONJ model rats. Forty-three rats, received two intravenous injections of zoledronic acid 60 μg/kg, once per week for a period of 2 weeks, underwent extraction of a unilateral lower first molar. The rats here were randomly assigned to the bFGF group (n = 15 rats, gelatin hydrogel sheets with incorporated bFGF applied over the sockets); the phosphate-buffered saline (PBS) group (n = 14 rats, gelatin hydrogel sheets without bFGF applied over the sockets); or the control group (n = 14 rats, nothing applied over the sockets). One rat in the bFGF group was sacrificed immediately after tooth extraction. Twenty-one rats were sacrificed at 3 weeks, and the remaining 21 rats were sacrificed at 8 weeks after tooth extractions. The harvested mandibles were analyzed using micro-computed tomography and sections were evaluated qualitatively for mucosal disruption and osteonecrosis. The incidence of osteonecrosis at 8 weeks after tooth extraction was 0% in the bFGF group, 100% in the PBS group, and 85.7% in the control group. The frequency of complete coverage of the extraction socket by mucosal tissue was significantly greater in the bFGF group than in the other groups. These results suggest that application of bFGF in the extraction socket promoted socket healing, which prevented BRONJ development. The growth-stimulating effects of bFGF may have offset the inhibition of wound healing by BP.

show abstract

The effectiveness of hydroxyapatite in alveolar ridge preservation: A systematic review

Razali,

Younis,

Ariffin

2024

JIOH

View full text Add to dashboard Cite

Aim: This systematic review is aimed to evaluate the clinical, radiographical, and histologic/histomorphometric outcomes of using hydroxyapatite (HA), either alone or in combination with other biomaterials in alveolar ridge preservation (ARP). The effects of particle sizes were also investigated. Materials and Methods: This study followed the requirements outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and was duly registered with the International Prospective Register of Systematic Reviews. Studies published from 2015 to 2021 were included, focusing on patients aged 18 years or older requiring tooth extraction. Various interventions and comparators were assessed, including HA alone and HA combined with organic/inorganic materials. Primary outcomes were the dimensional alveolar bone changes measured clinically and radiographically, whereas secondary outcomes included histological and histomorphometric evaluations. Results: A total of 15 studies were included, comprising case series, cohorts, and randomized controlled trials. HA, both alone and in combination, demonstrated potential in reducing alveolar bone resorption. Clinical and radiographic measurements revealed reduced horizontal and vertical ridge changes when HA was used. Histological analysis demonstrated favorable outcomes with the presence of new bone formation around residual graft particles. Conclusions: Combining HA with organic or inorganic materials showed promise in preserving alveolar ridge dimensions, with less residual graft material observed during implant placement. The use of nanoscale HA also demonstrated positive outcomes in bone regeneration. However, due to the heterogeneity of study designs, further research with larger sample sizes and uniform methodologies is needed to provide more definitive conclusions. In summary, HA, especially in combination with other materials, holds the potential for effective ARP, but standardization of approaches is essential for more reliable results in future studies.

show abstract

Evaluation of a Porous Hydroxyapatite Granule and Gelatin Hydrogel Microsphere Composite in Bone Regeneration

Cited by 3 publications

References 34 publications

New-generation osteoplastic materials based on biological and synthetic matrices

New-generation osteoplastic materials based on biological and synthetic matrices

Prevention of tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaws with basic fibroblast growth factor: An experimental study in rats

The effectiveness of hydroxyapatite in alveolar ridge preservation: A systematic review

Contact Info

Product

Resources

About