Bone density in women with prolactinoma treated with dopamine agonists

Naliato, Erika Cesar de Oliveira; Violante, A; Caldas, Dayse; Farias, Maria Lúcia Fleiuss; Bussade, Isabela; Filho, Adilson Lamounier; Loureiro, C. R.; Fontes, Rosita; Schrank, Yolanda; Loures, Thaissa; Colao, Annamaria

doi:10.1007/s11102-007-0064-4

Cited by 36 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, spinal bone mineral content is decreased by 20-30% [6,10,17,[19][20][21] while forearm bone mineral is decreased by 2.5-10% [3-6, 8, 10, 13, 17]. A few studies have used DXA to examine hipbone density which is also reduced but to a lesser extent than in the spine [18,19,[21][22][23]. The difference in bone loss between the sites is likely due to the more rapid turnover of trabecular bone.…”

Section: Prolactin and The Skeletonmentioning

confidence: 99%

The effects of hyperprolactinemia on bone and fat

Shibli-Rahhal

Schlechte

2008

Pituitary

View full text Add to dashboard Cite

Many patients with prolactin secreting pituitary tumors have decreased bone mineral. The bone loss is associated with an increase in bone resorption and is secondary to prolactin-induced hypogonadism. In both sexes trabecular bone in the spine and hip is more affected than cortical bone in the distal radius. Normalization of prolactin and restoration of gonadal function increases bone density but is not associated with normalization of bone mass. It is not known whether the bone loss in hyperprolactinemic subjects represents a failure to achieve peak bone mass or is due to accelerated bone loss. Despite low bone density hyperprolactinemic subjects do not demonstrate increased fractures. The association between prolactin, weight gain and obesity suggests that prolactin may also be a modulator of body composition and body weight. It is not known whether hyperprolactinemia associated weight gain is due to stimulation of lipogenesis or due to disruption of central nervous system dopaminergic tone. Hyperprolactinemia is also associated with insulin resistance and endothelial dysfunction which may improve after normalization of prolactin. The clinical significance of these findings and the precise role of prolactin in regulation of weight and metabolism remain to be elucidated.

show abstract

Section: Prolactin and The Skeletonmentioning

confidence: 99%

The effects of hyperprolactinemia on bone and fat

Shibli-Rahhal

Schlechte

2008

Pituitary

View full text Add to dashboard Cite

show abstract

“…It is well known the hyperprolactinemia associated bone loss in pre and post-menopause. [7,8,9] It seems that a direct effect of high prolactin levels on skeleton is presented independent of hypoestrogenic state. [10] The prolactinoma-osteoporosis association in a patient with history of kidney stone and associating a DXA pattern with the lowest T-score at distal radius increases the suspicion of a multiple endocrine neoplasia syndrome but in our case the repeated tests ruled out this condition.…”

Section: Discussionmentioning

confidence: 99%

Menopause and prolactin secreting tumours

Cârșote

Valea

Dumitrașcu

et al. 2015

ARS Medica Tomitana

View full text Add to dashboard Cite

IntroductionProlactinomas without galactorhhea may be considered menopause or not diagnosed. This is a cases series. Case1. 76-year female with menopause at age of 52 was discovered at 66 yrs with high prolactin and a pituitary micro-nodule. Bromocriptin was continued for 6 years then switched to cabergoline with constant imagery. The patient did not display at all galactorrhea. Osteoporosis was diagnosed at age of 66 with previous 2 fragility fractures. Case2. 45-year female is known with secondary amenorrhea (without galactorrhea) for the last 7 years being considered menopause. She experienced headaches thus a MRI was performed and found a pituitary tumour of 1.5cm. Low FSH with increased prolactin was revealed. Cabergoline was started. Within 2 months the menses resumed and headache mildly improved. After 3 months prolactin normalised under weekly 2 mg of cabergoline. Periodical prolactin control is necessary as well as a pituitary scan at 6 months. Case3. 39-year female had a 3 yrs history of secondary amenorrhea. A prolactin of 117ng/mL and a microprolactinoma of 0.77cm were found. Cabergoline was started and progressively increased up to 1.5mg per

show abstract

“…Por meio da técnica de radioimunoensaio, observou-se que os níveis séricos de PRL nem sempre coincidem com os achados clínicos, pois, devido a alterações pós-traducionais, como diamidação, glicolisação e fosforilação, há heterogeneidade na molécula de PRL circulante (Naliato et al, 2008).…”

Section: Tipos De Prolactinaunclassified

“…É desprovido de atividade enzimática intrínseca, mas pode sofrer fosforilação se associado a enzimas e proteínas (Kossiakoff, 2004 (Naliato et al, 2008).…”

Section: Receptor De Prolactina E Seu Mecanismo De Açãounclassified

Expressão gênica da prolactina e seus receptores na hipófise e no útero de camundongo fêmea tratado com metoclopramida

Amaral¹

View full text Add to dashboard Cite

Bone density in women with prolactinoma treated with dopamine agonists

Cited by 36 publications

References 28 publications

The effects of hyperprolactinemia on bone and fat

The effects of hyperprolactinemia on bone and fat

Menopause and prolactin secreting tumours

Expressão gênica da prolactina e seus receptores na hipófise e no útero de camundongo fêmea tratado com metoclopramida

Contact Info

Product

Resources

About