Body water metabolism in high altitude natives during and after a stay at sea level

Jain, Shikha; Bardhan, J; Swamy, Y.V.; Grover, Ashok K.; Nayar, Harry S.

doi:10.1007/bf02184438

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…By the use of a radio-labelled erythrocyte methodology, Sawka et al (1996) have recently reported a decrease in plasma volume by appoximately 11% after arrival at 4,300 m. Our data obtained with the CO rebreathing method are in support of such a magnitude of plasma loss during early exposure to hypoxaemia. With more sustained hypoxaemia, the decrease in albumin distribution volume that has been observed (Surks et al 1966;Hannon et al 1969;Frayser et al 1975;Jain et al 1980Jain et al , 1981Richalet et al 1983;Singh et al 1986), could be secondary to acclimatisation processes producing a gradual return to Values are means with 95% con®dence intervals; *P < 0.05 compared with sea level Fig. 2 The ratio between the volume of distribution of albumin (PV Evans' ) and the plasma volume measured by a carbon monoxide (CO) rebreathing method (PV CO ) at sea level and at high altitude.…”

Section: Discussionmentioning

confidence: 93%

“…Determination of plasma volume in hypoxic environments has been the subject of many studies (Surks et al 1966;Hannon et al 1969;Frayser et al 1975;Jain et al 1980Jain et al , 1981Richalet et al 1983;Singh et al 1986;Hansen et al 1994). In all of these, the distribution volume of radio-labelled albumin or Evans' blue has been used as a marker of the plasma volume.…”

Section: Introductionmentioning

confidence: 99%

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Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue

Poulsen

Klausen

Richalet

et al. 1998

European Journal of Applied Physiology

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Exposure to acute hypoxia is associated with changes in body fluid homeostasis and plasma volume (PV). This study compared a dye dilution technique using Evans' blue (PV[Evans']) with a carbon monoxide (CO) rebreathing method (PV[CO]) for measurements of PV in ten normal subjects at sea level and again 24 h after rapid passive ascent to high altitude (4,350 m). Hypobaric hypoxia decreased arterial oxygen saturation to 79 (74-83)% (mean with 95% confidence intervals). The PV(Evans') remained unchanged from 3.49 (3.30-3.68) l at sea level to 3.46 (3.24-3.68) l at high altitude. In contrast PV(CO) decreased from 3.39 (3.17-3.61) l at sea level to 3.04 (2.75-3.33) l at high altitude (P < 0.05). Compared with sea level, this resulted in an increase of the mean bias between the two methods [from 0.11 (-0.05-0.27) l at sea level to 0.43 (0.26-0.60) l at high altitude] so that the ratio between PV(Evans') and PV(CO) increased from 1.04 (0.99-1.09) at sea level to 1.15 (1.06-1.24) at high altitude (P < 0.05). In conclusion, the two methods were not interchangeable as measures of hypoxia-induced changes in PV. The mechanism responsible for the bias remains unknown, but it is suggested that the results may reflect a redistribution of albumin caused by the combined effects in hypoxia of both an increased capillary permeability to albumin and a decrease in PV. As a result, the small perivascular compartment of albumin beyond the endothelium may increase without changes in the overall albumin distribution volume.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue

Poulsen

Klausen

Richalet

et al. 1998

European Journal of Applied Physiology

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“…Oncotic pressure differences have also been estimated during HH, with increases occurring as early as 24 h into a terrestrial altitude sojourn (4200 m) 48 . The acute barometric pressure decrease experienced at HH may provide the early stimulus for commonly observed acclimatization dependent body water changes 18 , 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Total body water, extracellular fluid, intracellular fluid, and plasma volume decreases are commonly reported after terrestrial altitude ascent from sea level after ≥ 2 days due to increased diuresis [18][19][20][21] . Body fluid decreases are most often ascribed to an increased respiratory water loss and/or urinary output 19,20,29 . It is thereby expected that our observed body water losses at HH reflect both respiratory water loss and urine output avenues.…”

Section: Nn Nh Hhmentioning

confidence: 99%

Independent effects of acute normobaric hypoxia and hypobaric hypoxia on human physiology

Rosales

Shute

Hailes

et al. 2022

Sci Rep

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The purpose of this study was to examine the effects of acute normobaric (NH, decreased FiO2) and hypobaric (HH, 4200 m ascent) hypoxia exposures compared to sea level (normobaric normoxia, NN). Tissue oxygenation, cardiovascular, and body fluid variables measured during rest and a 3-min step-test following 90-min exposures (NH, HH, NN). Muscle oxygenated hemoglobin (O2Hb) decreased, and muscle deoxygenated hemoglobin (HHb) increased environmentally independent from rest to exercise (p < 0.001). During exercise, brain O2Hb was lower at HH compared to NN (p = 0.007), trending similarly with NH (p = 0.066), but no difference between NN and NH (p = 0.158). During exercise, HR at NH (141 ± 4 beats·min−1) and HH (141 ± 3 beats·min−1) were higher than NN (127 ± 44 beats·min−1, p = 0.002), but not each other (p = 0.208). During exercise, stroke volume at HH (109.6 ± 4.1 mL·beat−1) was higher than NH (97.8 ± 3.3 mL·beat−1) and NN (99.8 ± 3.9 mL·beat−1, p ≤ 0.010) with no difference between NH and NN (p = 0.481). During exercise, cardiac output at NH (13.8 ± 0.6 L) and HH (15.5 ± 0.7 L) were higher than NN (12.6 ± 0.5 L, p ≤ 0.006) with HH also higher than NH (p = 0.001). During acute hypoxic stimuli, skeletal muscle maintains oxygenation whereas the brain does not. These differences may be mediated by environmentally specific cardiovascular compensation. Thus, caution is advised when equating NH and HH.

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“…From a whole-body perspective, it also appears that calculated intracellular water generally decreases (63,67,68,83,101,117). However, experimental variables can influence the effects of hypoxia on total body water and body fluid distribution.…”

Section: Special Conditions Influencing Body Fluid Homeostasismentioning

confidence: 99%

Body Fluid and Energy Metabolism at High Altitude

Hoyt

Hönig

1996

Comprehensive Physiology

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Body water metabolism in high altitude natives during and after a stay at sea level

Cited by 5 publications

References 14 publications

Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue

Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue

Independent effects of acute normobaric hypoxia and hypobaric hypoxia on human physiology

Body Fluid and Energy Metabolism at High Altitude

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