Body mass index effect on common nerve conduction study measurements

Buschbacher, Ralph M.

doi:10.1002/(sici)1097-4598(199811)21:11<1398::aid-mus6>3.0.co;2-4

Cited by 120 publications

(98 citation statements)

References 13 publications

(4 reference statements)

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“…These results indicate that exercise is effective as a protective and therapeutic method against DPN. The biological variables for NCV determination include temperature, age, height and the effects of volume conduction (22). Similar to the results from a previous study (23), in this study, it was also found that caudal NCV in the control rats significantly increased as the rats grew (23).…”

Section: Caudal Ncv (M/s) -------------------------------------------supporting

confidence: 90%

Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats

Zhang

et al. 2012

Mol Med Report

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Abstract. The aim of the present study was to explore the role of exercise in diabetic peripheral neuropathy (DPN) and the mechanisms involved. For this purpose, 31 male SpragueDawley rats were used. The rats were assigned to 5 groups: diabetic rats subjected to exercise training (swimming) for 8 weeks (D-Ex1 group), diabetic rats subjected to exercise training for 4 weeks after 4 weeks of being sedentary (D-Ex2 group), diabetic rats which remained sedentary for 8 weeks (D-Sed group), control rats subjected to exercise training for 8 weeks (C-Ex1 group) and control rats which remained sedentary for 8 weeks (C-Sed group). Blood glucose levels and caudal nerve conduction velocity (NCV) were evaluated at 0 (baseline), 28 (4 weeks) and 56 days (8 weeks) after the induction of diabetes. The levels of neurotrophin-3 (NT-3) in skeletal muscle were measured by ELISA at the end of the experiment. Blood glucose levels in the D-Ex1 group rats decreased significantly after 8 weeks of exercise. The caudal NCV markedly decreased in all diabetic rats and significantly increased after 4 or 8 weeks of exercise training. Muscle NT-3 levels were significantly lower in the D-Sed compared to the 4 other groups. Muscle NT-3 levels positively correlated with caudal NCV. In conclusion, swimming training has a beneficial effect on DPN and muscle NT-3 levels, which could help improve caudal NCV in streptozotocin-induced diabetic rats. IntroductionDiabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and is responsible for 50-75% of non-traumatic amputations in developed countries (1,2). The streptozotocin (STZ) model is widely used to investigate experimental DPN (3). Abnormal nerve conduction is an early feature of diabetic nerve damage (4). Tesfaye et al showed that conduction velocity significantly increased after exercise in normal subjects (5). Selagzi et al found that exercise training significantly increased the compound muscle action potential amplitude and decreased motor latency in diabetic rats (4). However, little is known about the mechanisms involved in exersise improving nerve dysfunction in STZ-induced diabetic rats.Neurotrophin-3 (NT-3) is a type of neurotrophic factor that comprises a heterogeneous group of molecules produced by neurons, Schwann cells and end organs in the central and peripheral nervous system (PNS). In adults, neurotrophins of the PNS are synthesized in and released from target tissues. Skeletal muscles are such target tissues and produce neurotrophins. NT-3 plays a crucial role in mediating central nervous system plasticity and regeneration in the spinal cord and muscle. Short-term STZ-induced diabetes causes a reduction in muscle NT-3 mRNA and protein expression, which leads to a decreased retrograde axonal transport of NT-3 to the neuronal cell body and consequent sub-optimal neurotrophic support (6). Previous studies have shown that the continuous production of NT-3 by the latency-associated promoter 2 (LAP2)-driven expression of the transgene from a herpes simple...

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Section: Caudal Ncv (M/s) -------------------------------------------supporting

confidence: 90%

Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats

Zhang

et al. 2012

Mol Med Report

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“…The increased BMI and lower sensory/mixed nerve amplitudes should be taken into account in clinical practice [20]. The NCV correlates more strongly with the height than with the age [21].…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological status of sural nerves in type 2 diabetes mellitus patients before symptomatic peripheral neuropathy

Panta

Thakur

Paudel

2017

Clinical Diabetology

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“…[9] Other groups could not find a statistical difference in NCVs of different BMI groups. [7,10] The attributable reason postulated in the studies where NCV was either negatively correlating with or not affected by BMI was the effect of obesity per se causing inflammation leading deterioration of nerve function or subcutaneous fat pad causing hindrance in conduction recordings.…”

Section: Discussionmentioning

confidence: 99%

“…[6] In another study, there was inverse correlation between compound action potential and body mass index (BMI), but no correlation was observed between BMI and NCV. [7] In a study performed on healthy subjects, the conduction velocity of calcaneal sensory nerve action potential (NAP) and distal posterior tibial and lateral plantar motor NAP was found to decrease with height and BMI. [8] In the same line, another study reports decreased sensory NAP amplitude decreases with increasing BMI.…”

Section: Introductionmentioning

confidence: 99%

Ulnar nerve motor conduction velocity correlates with body mass index in Indian young healthy subjects

Kumar¹,

Sarvottam²,

Yadav³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background:The prevalence of obesity is on rise globally, which poses a risk of vascular inflammation and metabolic dysregulations. Nerve conduction is affected by altered lipid metabolism, inflammation, and oxidative stress. Motor nerve conduction velocity (NCV) is a routine electrodiagnostic technique for detecting changes in nerve conduction parameters. There are contrasting results in studies done to investigate the relationship between NCV and body mass index (BMI). Few studies show increased conduction velocity with an increase in BMI, while others found either decreased or no change in conduction velocity with change in BMI. Aims and Objectives: The objective of this study was to investigate the relationship between motor NCV and BMI. Materials and Methods: In this study, we selected 27 individuals with normal weight, overweight, and obese categorized based on BMI and performed ulnar and median NCV. Correlation statistics were applied to see the relationship between BMI and motor NCV. Results: We found significant positive correlation between BMI and ulnar motor NCV (P = 0.027, r = 0.43). Ulnar and median NCV was also found correlating significant (P = 0.021, r = 0.45). Conclusion: The findings of our study suggest that the NCV correlates with BMI in lower BMI groups due to the maintenance of local optimum temperature, while in people with higher BMI inflammatory changes impair nerve conduction, a comparison in larger sample size is required to substantiate this observation is required though.

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Body mass index effect on common nerve conduction study measurements

Cited by 120 publications

References 13 publications

Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats

Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats

Electrophysiological status of sural nerves in type 2 diabetes mellitus patients before symptomatic peripheral neuropathy

Ulnar nerve motor conduction velocity correlates with body mass index in Indian young healthy subjects

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