Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats

Li, Hongwei; Zhang, Shen; Lu, Yanjin; Feng, Lin; Wu, Yingliang; Jiang, Zhongli

doi:10.3892/mmr.2012.897

Cited by 10 publications

(5 citation statements)

References 29 publications

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“…20,30 Exercise-induced increases in NT-3 may be responsible for increased neurite outgrowth of injured DRG neurons in vitro, and increased conduction velocity in injured nerves. 40,45 Induction of factors such as NT-3 may protect against CCI-induced damage, to attenuate a secondary neuroimmune response. A second potential mechanism involves induction of endogenous opioids after exercise.…”

Section: Discussionmentioning

confidence: 99%

Prior voluntary wheel running attenuates neuropathic pain

Grace

Fabisiak

Green‐Fulgham

et al. 2016

Pain

112

158

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Exercise is known to exert a systemic anti-inflammatory influence, but whether its effects are sufficient to protect against subsequent neuropathic pain is underinvestigated. We report that 6 weeks of voluntary wheel running terminating before chronic constriction injury (CCI) prevented the full development of allodynia for the ∼3-month duration of the injury. Neuroimmune signaling was assessed at 3 and 14 days after CCI. Prior exercise normalized ipsilateral dorsal spinal cord expression of neuroexcitatory interleukin (IL)-1β production and the attendant glutamate transporter GLT-1 decrease, as well as expression of the disinhibitory P2X4R-BDNF axis. The expression of the macrophage marker Iba1 and the chemokine CCL2 (MCP-1), and a neuronal injury marker (activating transcription factor 3), was attenuated by prior running in the ipsilateral lumbar dorsal root ganglia. Prior exercise suppressed macrophage infiltration and/or injury site proliferation, given decreased presence of macrophage markers Iba1, iNOS (M1), and Arg-1 (M2; expression was time dependent). Chronic constriction injury–driven increases in serum proinflammatory chemokines were suppressed by prior running, whereas IL-10 was increased. Peripheral blood mononuclear cells were also stimulated with lipopolysaccharide ex vivo, wherein CCI-induced increases in IL-1β, nitrite, and IL-10 were suppressed by prior exercise. Last, unrestricted voluntary wheel running, beginning either the day of, or 2 weeks after, CCI, progressively reversed neuropathic pain. This study is the first to investigate the behavioral and neuroimmune consequences of regular exercise terminating before nerve injury. This study suggests that chronic pain should be considered a component of “the diseasome of physical inactivity,” and that an active lifestyle may prevent neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

Prior voluntary wheel running attenuates neuropathic pain

Grace

Fabisiak

Green‐Fulgham

et al. 2016

Pain

112

158

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“…Swimming exercise was performed without a load in a barrel filled with water at 33–35 °C to a depth of 40–50 cm, which allowed free swimming [ 20 ]. The duration of the first swimming exercise was limited to 15 min and increased by 5 min daily up to 30 min.…”

Section: Methodsmentioning

confidence: 99%

Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats

Lu¹,

Li²,

Shen

et al. 2016

Lipids Health Dis

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BackgroundIt has been shown that irisin levels are reduced in skeletal muscle and plasma of obese rats; however, the effect of exercise training on irisin level remains controversial. We aim to evaluate the association of swimming exercise with serum irisin level and other obesity-associated parameters.MethodsForty healthy male Wistar rats were randomly assigned to 4 groups: a normal diet and sedentary group (ND group), normal diet and exercise group (NDE group), high-fat diet and sedentary group (HFD group), and high-fat diet and exercise group (HFDE group. After 8 consecutive weeks of swimming exercise, fat mass and serum irisin level was determined.ResultsHigher serum irisin levels were detected in the HFDE group (1.15 ± 0.28 μg/L) and NDE group (1.76 ± 0.17 μg/L) than in the HFD group (0.84 ± 0.23 μg/L) or the ND group (1.24 ± 0.29 μg/L), respectively (HFDE group vs. HFD group, P < 0.05; NDE group vs. ND group, P < 0.01). Pearson’s correlation analysis showed that serum irisin level negatively correlated with TG level (r = −0.771, P < 0.05), percentage fat mass (r = −0.68, P < 0.05), fat mass (r = −0.576, P < 0.05), visceral fat mass (r = −0.439, P < 0.05) and TC level (r = −0.389, P < 0.05). The fat mass, visceral fat mass and percentage fat mass were lower in the HFDE group than the HFD group (all P values < 0.01).ConclusionSwimming exercise decreases body fat mass in high-fat-fed Wistar rats, which may be attributable to elevated irisin levels induced by swimming exercise.

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“…Each swim consisted of five 24-min bouts separated by 10-min rest times. The water was filled to a depth of 100 cm and maintained at 35°C, which was large enough for each rat to swim freely as previously published (Li et al, 2012; McCullough et al, 2013). …”

Section: Methodsmentioning

confidence: 99%

Glial cell line-derived neurotrophic factor (GDNF) expression and NMJ plasticity in skeletal muscle following endurance exercise

2014

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Glial cell-line derived neurotrophic factor (GDNF) supports and maintains the neuromuscular system during development and through adulthood by promoting neuroplasticity. The aim of this study was to determine if different modes of exercise can promote changes in GDNF expression and neuromuscular junction (NMJ) morphology in slow and fast twitch muscles. Rats were randomly assigned to a run training (run group), swim training (swim group), or sedentary control group. GDNF protein content was determined by enzyme-linked immunosorbant assay. GDNF protein content increased significantly in soleus (SOL) following both training protocols (P < 0.05). Although not significant, an increase of 60% in the extensor digitorum longus (EDL) followed swim-training (NS; P < 0.06). NMJ morphology was analyzed by measuring α-bungarotoxin labeled post-synaptic end plates. GDNF content and total end plate area were positively correlated. End plate area decreased in EDL of run group and increased in SOL of swim group. The results indicate that GDNF expression and NMJ morphological changes are activity dependent and that different changes may be observed by varying the exercise intensity in slow and fast twitch fibers.

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Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats

Cited by 10 publications

References 29 publications

Prior voluntary wheel running attenuates neuropathic pain

Prior voluntary wheel running attenuates neuropathic pain

Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats

Glial cell line-derived neurotrophic factor (GDNF) expression and NMJ plasticity in skeletal muscle following endurance exercise

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