Body fat indices as effective predictors of insulin resistance in obese/non-obese polycystic ovary syndrome women in the Southwest of China

Huang, Xin; Wang, Qiuyi; Liu, Tingting; Pei, Tianjiao; Liu, Dong; Zhu, Huili; Huang, Wei

doi:10.1007/s12020-019-01912-1

Cited by 28 publications

(23 citation statements)

References 22 publications

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“…The current study is significant as it presents the cutoff values of VAI and LAP by sex, using a large and healthy population. Interestingly, the VAI cutoff value identified in this study is similar to the VAI cutoff value of 1.6-1.8 reported in the previous studies with PCOS patients 27,45,46 . However, in the case of LAP, previous studies have Table 3.…”

Section: Discussionsupporting

confidence: 89%

“…In addition to studies measuring insulin resistance directly, there are numerous studies on the accuracy of VAI and LAP in assessing HOMA-IR defined insulin resistance. However, studies on cutoff values were mainly conducted on a small number of PCOS patients [45][46][47] . Thus, a study with a larger population with healthy adults is necessary.…”

Section: Discussionmentioning

confidence: 99%

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Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

Lee

Kim

et al. 2021

Sci Rep

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This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

Lee

Kim

et al. 2021

Sci Rep

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“…Additionally, FLI was cross-validated in large studies with sensitivity and specificity of 80.3 and 87.3%, respectively, in comparison to ultrasound (33). Moreover, in our study, we used measures of liver fat derived from well-validated algorithms (5, 20, 32, 33, 34). Another possible limitation of the present study could be the measurement of total testosterone by RIA and not with the liquid chromatography-tandem mass spectrometry (LC-MS) method.…”

Section: Discussionmentioning

confidence: 99%

Increased serum fetuin-B concentration is associated with HOMA-β and indices of liver steatosis in women with polycystic ovary syndrome: a pilot study

Adamska

Polak

Krentowska

et al. 2019

Endocrine Connections

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Objective PCOS women are characterized by insulin resistance and have higher tendency to the development of hepatic steatosis. Fetuin-B has been introduced as a hepatokine/adipokine, which is increased in hepatic steatosis and may be connected with glucose metabolism disturbances. The aim of the study was to evaluate the relationships between serum fetuin-B concentration and indices of insulin resistance, insulin secretion and markers of liver steatosis in PCOS women in comparison to the control group. Patients and methods The study group included 108 women – 57 women with PCOS and 51 women matched for age and BMI as a control group. Serum concentration of fetuin-B was estimated. Homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment β cell function (HOMA-β) were calculated. Fatty liver index (FLI), lipid accumulation product (LAP) and visceral adiposity index (VAI) were used as markers of liver steatosis. Results We found higher serum concentration of fetuin-B and FLI in PCOS women in comparison to the control group (all P < 0.05). We observed a positive relationship between serum fetuin-B concentration and HOMA-β (r = 0.43, P = 0.01), HOMA-IR (r = 0.31, P = 0.01), FLI (r = 0.29, P = 0.02), VAI (r = 0.29, P = 0.02) and LAP (r = 0.32, P = 0.01) in PCOS women. We also noticed a relationship between HOMA-IR and FLI (r = 0.42, P = 0.01), VAI (r = 0.38, P = 0.004) and LAP (r = 0.41, P = 0.001) in this group. Multiple regression analysis revealed that HOMA-β (β = 0.39, P = 0.002) and LAP (β = 0.27, P = 0.02) were independently connected with serum fetuin-B levels in women with PCOS. Conclusions Serum fetuin-B levels are higher in women with PCOS and are independently connected with HOMA-β and hepatic steatosis.

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“…WHtR (waist-to-height ratio) is a maker of abdominal obesity and studies have also reported that WHtR is related to IR 14 15 and also the higher risk of NAFLD. [16][17][18][19][20][21][22] Whether there is an existing effect of TyG index on the relationship between WHtR and NAFLD and how it affects NAFLD is still unclear. This retrospective cohort study therefore sought to explore the relationship between baseline level of TyG index and the incidence of NAFLD.…”

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confidence: 99%

Relationship between triglyceride glucose index and the incidence of non-alcoholic fatty liver disease in the elderly: a retrospective cohort study in China

Chen

Amoah

et al. 2020

BMJ Open

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ObjectiveNon-alcoholic fatty liver disease (NAFLD) is one of the major causes of liver-related diseases but relationship between triglyceride glucose (TyG) and NAFLD in the elderly is not reported yet. In this study, we investigated the role of TyG index for predicting the incidence of NAFLD in the elderly.Design and settingThis is a prospective cohort study in Henan, China, from 2011 to 2018.Participants and methodsIn total, 46 693 elderly who participated in a routine physical examination programme from 2011 to 2018 were included in this study. TyG index was calculated as ln (fasting triglyceride (mg/dL)×fasting plasma glucose (mg/dL)/2), while NAFLD was defined as hepatic steatosis after excluding other causes based on the results of abdominal ultrasonography; Cox regression model was performed to explore the relationship between TyG index and NAFLD. Also, mediation effect was used to analyse the role of the TyG index in WHtR (waist-to-height ratio) and NAFLD.ResultsDuring the 149 041 person-years follow-up, a total of 5660 NAFLD events occurred (3.80/100 person-years). After adjusting for potential confounding factors, quartiles 4 of TyG index significantly increased the incidence of NAFLD compared with quartile 1, the HRs and 95% CI were 1.314 (1.234 to 1.457). In addition, TyG index played a partial mediating role in the relationship between WHtR and NAFLD and indirect effect was 1.009 (1.006 to 1.011).ConclusionHigher TyG index was associated with higher risk of NAFLD in the aged, and therefore, TyG index may be a novel predictor for incidence of NAFLD. Further, regular examination and evaluation of the TyG index might be useful for controlling the occurrence of NAFLD.

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Body fat indices as effective predictors of insulin resistance in obese/non-obese polycystic ovary syndrome women in the Southwest of China

Cited by 28 publications

References 22 publications

Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

Increased serum fetuin-B concentration is associated with HOMA-β and indices of liver steatosis in women with polycystic ovary syndrome: a pilot study

Relationship between triglyceride glucose index and the incidence of non-alcoholic fatty liver disease in the elderly: a retrospective cohort study in China

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