Increased serum fetuin-B concentration is associated with HOMA-β and indices of liver steatosis in women with polycystic ovary syndrome: a pilot study

Adamska, Agnieszka; Polak, Aleksandra; Krentowska, Anna; Łebkowska, Agnieszka; Hryniewicka, Justyna; Leśniewska, Monika; Kowalska, Irina

doi:10.1530/ec-19-0243

Cited by 14 publications

(11 citation statements)

References 37 publications

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“…In the present study, we further confirm that serum fetuin-B levels were significantly increased in women with IR and IGT, and significantly correlated with BMI, HOMA-IR, and glucose and lipid metabolism. This was consistent with the results of Adamska et al in the PCOS population ( Adamska et al, 2019 ). Based on the following reasons, we believe that our results are accurate and reliable: (1) we selected young subjects as the research objects and thus avoided age-related IR; (2) we chose women as the research subjects and avoided the influence of sex hormones on insulin sensitivity in vivo; (3) our subjects did not use drug treatments or lifestyle interventions, avoiding interventional influence on serum fetuin-B levels.…”

Section: Discussionsupporting

confidence: 94%

Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

Xue

Yang

et al. 2021

PeerJ

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Background and Aims Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fetuin-B and the occurrence and development of IR. Methods A total of 304 women were enrolled in this study and subjected to both OGTT and EHC. A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA. Results In IGT and IR-NG groups, serum fetuin-B levels were higher than those in the NGT group. The serum fetuin-B levels in the IGT group were higher than those in the IR-NG group. serum fetuin-B was positively correlated with BMI, WHR, 2h-BG, FIns, HbA1c, and HOMA2-IR, but negatively correlated with the M-value in all study populations. Multiple stepwise regression analysis showed that the M-value was independently and inversely associated with serum fetuin-B. Logistic regression analysis showed that serum fetuin-B was independently associated with IGT and significantly increased the risk of IGT. During the OGTT, serum fetuin-B increased significantly in the NGT group, but there were no significant changes in other groups. During the EHC, serum fetuin-B increased in the IGT group, but there was no change in other groups. After Lira intervention, serum fetuin-B decreased significantly in IGT women. Conclusions serum fetuin-B levels are elevated in young women with IR or IGT and may be associated with IR.

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Section: Discussionsupporting

confidence: 94%

Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

Xue

Yang

et al. 2021

PeerJ

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“…These results were similar to those noted in previous publications regarding other metabolic diseases, such as T2DM, NAFLD, and GDM [ 11 , 12 , 15 , 21 ]. In addition, when our manuscript was being submitted, Adamska et al published a pilot study that found that the serum Fetuin-B concentration in PCOS women was significantly higher than that in healthy controls, which was consistent with our results [ 22 ]. However, unlike the current study, the previous study was a small sample observational study.…”

Section: Discussionsupporting

confidence: 90%

Elevated Circulating Fetuin-B Levels Are Associated with Insulin Resistance and Reduced by GLP-1RA in Newly Diagnosed PCOS Women

Mokou

Yang

Zhan

et al. 2020

Mediators of Inflammation

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Background. Previous studies have suggested that Fetuin-B seems to be a secreted adipokine related to metabolic diseases. However, the results have been inconsistent. Here, our objective is to investigate the changes in circulating Fetuin-B levels in women with polycystic ovary syndrome (PCOS) and analyze the association of Fetuin-B and insulin resistance (IR). Methods. The current study is comprised of a cross-sectional study and a series of interventional studies. Oral glucose tolerance test (OGTT) and euglycemic-hyperinsulinemic clamp (EHC) were engaged to assess glucose tolerance and insulin sensitivity. Serum Fetuin-B levels were determined by ELISA. Results. Serum Fetuin-B and TNF-α levels were markedly increased in women with PCOS compared to healthy women. Circulating Fetuin-B was positively associated with body mass index, waist-to-hip ratio, the percentage of body fat (FAT%), systolic blood pressure, triglyceride, low-density lipoprotein cholesterol, fasting blood glucose, 2 h blood glucose after glucose overload, fasting insulin, 2 h insulin after glucose overload, HOMA-insulin resistance index (HOMA-IR), the area under the curve for insulin (AUCi), AUCg, and TNF-α, while negatively associated with M value and follicular stimulating hormone (FSH). During the EHC, Fetuin-B levels were found to be significantly increased in PCOS women. After a glucose challenge, serum Fetuin-B levels in healthy women were significantly increased. Lipid infusion reduced serum Fetuin-B levels in 30 healthy subjects. After six months of glucagon-like peptide-1 receptor agonist (GLP-1RA) intervention, serum Fetuin-B concentrations in PCOS women markedly decreased following ameliorated IR. Conclusion. Our results indicate that Fetuin-B may be a biomarker of IR in individuals with PCOS. This trial is registered with ChiCTR-IIR-16007901.

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“…This protein was strongly associated with energy metabolism (9). Several case-control and cross-sectional studies have reported that circulating fetuin-B concentration was obviously elevated in patients with NAFLD, T2DM, GDM, and PCOS (13,14,15). However, most of these studies were preliminary explorations and did not adequately demonstrate the association of fetuin-B with IR in humans nor use state-of-the-art methodology.…”

Section: Discussionmentioning

confidence: 99%

“…In a clinical study, serum fetuin-B was found to be strongly associated with triglyceride (TG) contents in the liver, abdominal obesity, IR, and early insulin secretion stimulated by glucose (11,12). It has also been reported that the fetuin-B concentrations in patients with nonalcoholic fatty liver (NAFLD), T2DM, polycystic ovary syndrome (PCOS), and gestational diabetes mellitus (GDM) are signi cantly increased compared with healthy controls (13,14,15). Furthermore, fetuin-B is also considered to be related to cardiovascular disease (CVD) and chronic kidney disease (CKD) (16,17).…”

Section: Introductionmentioning

confidence: 99%

High serum Fetuin-B levels are associated with the presence of metabolic syndrome in women: a case-controlled study and interventional studies

Xue¹,

Ren²,

Yang³

et al. 2020

Preprint

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Background: Previous studies have investigated circulating fetuin-B and its association with type 2 diabetes mellitus (T2DM). However, the variation and regulatory factors of serum fetuin-B levels in individuals with metabolic syndrome (MetS) have not been explained. This study evaluated circulating fetuin-B concentrations in newly diagnosed individuals with MetS and analyzed the impacts of blood glucose, insulin, and glucagon-like peptide-1 receptor agonists (GLP-1RA) treatment on circulating fetuin-B in vivo.Methods: A total of 377 women (192 MetS and 185 healthy subjects) were recruited for cross-sectional study. The euglycemic-hyperinsulinemic clamp (EHC) and oral glucose tolerance test (OGTT) were implemented in healthy women and those with MetS. Serum fetuin-B were examined by an ELISA kit. For the GLP-1RA intervention experiment, twenty-four women with MetS were treated with Liraglutide for 6 months. Results: Serum fetuin-B levels were markedly higher in women with MetS as compared to healthy women. Circulating fetuin-B reflected a positive correlation with body mass index, waist hip ratio (WHR), the percentage of fat in vivo (FAT%), triglyceride, fasting blood glucose, 2-hour blood glucose after glucose overload, glycosylated hemoglobin, fasting plasma insulin, 2-hour plasma insulin after glucose overload, homeostasis model assessment of insulin resistance (HOMA-IR), visceral adiposity index (VAI), and lipid accumulation product (LAP). Multivariate linear regression analyses demonstrated that triglyceride and WHR were independently related factors of serum fetuin-B. Serum fetuin-B levels were related to MetS by binary logistic regression analysis. In fact, serum fetuin-B was markedly elevated in healthy women after glucose loading and in MetS women during the EHC. After six months of GLP-1RA intervention, serum fetuin-B levels in MetS subjects decreased following improvement of metabolism and insulin sensitivity. Conclusions: Serum fetuin-B levels were associated with MetS and its components and regulated by glucose and insulin. GLP-1RA treatment can reduce serum fetuin-B levels in women with MetS. Clinical Trial Registration Number: ChiCTR-OCS-13003185. Registered 02/01 2016, http://www.chictr.org.cn/showproj.aspx?proj=6374

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Increased serum fetuin-B concentration is associated with HOMA-β and indices of liver steatosis in women with polycystic ovary syndrome: a pilot study

Cited by 14 publications

References 37 publications

Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

Elevated Circulating Fetuin-B Levels Are Associated with Insulin Resistance and Reduced by GLP-1RA in Newly Diagnosed PCOS Women

High serum Fetuin-B levels are associated with the presence of metabolic syndrome in women: a case-controlled study and interventional studies

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