BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement

Tao, Bailong; Deng, Yiman; Song, Liying; Ma, Wenwen; Qian, Ying; Lin, Changjian; Yuan, Zhangfu; Lu, Lu; Chen, Maowen; Yang, Xin; Cai, Kaiyong

doi:10.1016/j.colsurfb.2019.02.014

Cited by 79 publications

(61 citation statements)

References 36 publications

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“…Moreover, bacteria that irreversibly adhered to the surface of solid material or tissue and have a great tendency to pack themselves in self‐produced extracellular polymeric substances comprised of exopolysaccharides, extracellular bacterial DNA, enzymes and protein, and ultimately forming biofilm (Jin et al, 2014). The formed biofilms serve as a stable barrier to protect the inside bacteria from antibiotic infiltration and host innate immune defense (Tao et al, 2019; Xiao et al, 2019). Therefore, the anti‐biofilm ability is one of the significant properties of antibacterial materials to achieve desired antibacterial efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…The extracellular pH plays a critical role in bone formation resorption and regulation of bacterial behavior (Tao et al, 2016). For instance, it was observed that a marginally high pH value (approximately pH 8) exerted positive effects on the proliferation and ALP activity of osteoblasts (Tao, Deng, et al, 2019). Moreover, the osteoblast viability was significantly improved under an appropriate alkaline environment (Tan et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Yang

Tao

Gong

et al. 2020

J Biomedical Materials Res

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After bone tumor resection, the large bony deficits are commonly reconstructed with Ti‐based metallic endoprosthesis, which provide immediate stable fixation and allow early ambulation and weight bearing. However, when used in osteosarcoma resection, Ti implant‐relative infection and tumor recurrence were recognized as the two critical factors for implantation failure. Hence, in this work, a novel zinc oxide nanoparticle decorating with naringin was prepared and immobilized onto Ti substrate. The drugs delivery profiles proved that in the bacterial infection and Warburg effect of osteosarcoma‐induced acidic condition, naringin and Zn2+ can be released easily from the functional Ti substrate. The anti‐osteosarcoma and antibacterial assay showed the delivered naringin and Zn2+ can induce a remarkable increase of oxidative stress in bacteria (Escherichia coli and Staphylococcus aureus) and osteosarcoma (Saos‐2 cells) by producing reactive oxygen species (ROS). Accumulation of ROS results in damage of bacterial biofilm and bacterial membrane, leading to the leakage of bacterial RNA and DNA. Meanwhile, the increase of ROS induces osteosarcoma cell apoptosis by activating ROS/extracellular signal‐regulated kinase signaling pathway. Furthermore, in vitro cellular experiments, including cell viability, alkaline phosphatase activity, collagen secretion, extracellular matrix mineralization level, indicated that the functional Ti substrate exhibited great potential for osteoblasts proliferation and differentiation. Hence, this study provides a simple and promising strategy of developing multifunctional Ti‐based implants for the reconstruction of large bony after osteosarcoma resection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Yang

Tao

Gong

et al. 2020

J Biomedical Materials Res

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“…TiNTs have potential applications in several fields; they are found in biomaterials, gas sensors, adsorbents, heterogeneous catalysis ( photocatalysis, oxidation reactions, organic synthesis, biomass,…), biological activities to remove bacteria from water, solar cells, Li battery production, and many others. In particular, TiNTs have been used as a catalytic support for different active species (metals, oxides and sulfides).…”

Section: Introductionmentioning

confidence: 99%

Study of 1D Titanate‐Based Materials –New Modification of the Synthesis Procedure and Surface Properties‐Recent Applications

Ameur

Bachir

2020

ChemistrySelect

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This paper represents a general study of titanate nanotubes (TiNTs) which are among the most important materials in the field of catalysis. This research work covers more than 100 publications about the formulation, characterisation and most recent applications of TiNTs. TiNTs can be prepared by different methods, namely the anodic deposition, sol-gel template synthesis and alkaline hydrothermal treatment. The present study focuses on the preparation of this tubular structure by alkaline treatment, using the latest and most recent processes that have been introduced in this method (stirring, acid nature, annealing temperature, etc). The surface properties, such as the point of zero charge (P.Z.C), acid-base nature and light absorption, of TiNTs are also evoked. In the end, some recent and important TiNTs applications in the field of renewable energies are reported (H 2 production and methanation). In addition, NO reduction, CO oxidation, photocatalysis and organic synthesis are also mentioned. Therefore, it may be said that this paper is a structured study about TiNTs for the purpose of making the reader aware of their importance, understand their synthesis, and know their scope of applications. To conclude, the most important data, acquired through various characterization techniques, are provided.[a] Dr.

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“…Despite that, Ti‐based implant cannot effectively integrate with surrounding bone tissue owing to its bioinert surface (Hu et al, ). In addition, implant‐associated infection would occur after implant surgery in some cases, remaining as one of the severe postoperative complications (Liao et al, ; Tao et al, ; Xie et al, ). Furthermore, it would in turn result in forming biofilm onto the Ti implant, even causing implant failure (Wang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Zn‐incorporation with graphene oxide on Ti substrates surface to improve osteogenic activity and inhibit bacterial adhesion

Tao

Chen

Lin

et al. 2019

J Biomedical Materials Res

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The poor osseointegration and postoperative bacterial infection are prominently responsible for the failure of titanium (Ti)-based implant in clinic. To address above issues, methacryloyl modified graphene oxide (GOMA) as zinc ions (Zn 2+ ) reservoir and release platform was fabricated on the Ti substrates with cathode electrophoresis deposition (EPD). Afterward, phenylboronic acid (PBA) functionalization methacryloylgelatin (GelMA-PBA) was reacting with GOMA through in situ free-radical polymerization to prepare GO-Zn/GelMA-PBA coating. The obtained coating was confirmed by scanning electron microscopy, X-ray photoelectron spectroscopy, and Zn ions release property, respectively. in vitro cellular experiments including cell activity, alkaline phosphatase, collagen secretion, extracellular matrix (ECM) mineralization, osteogenic genes and proteins, revealed that GO-Zn/GelMA-PBA coating was beneficial for enhancing the adhesion, proliferation, and differentiation of osteoblasts. The positive results were related to the existence of gelatin, formation of boronic ester between PBA groups, and carbohydrates of osteoblasts surface. Meanwhile, antibacterial assay against Staphylococcus aureus and Pseudomonas aeruginosa confirmed that GO-Zn/GelMA-PBA coating on Ti substrates had superior antibacterial capacity, availably inhibited the bacterial adhesion, and prevented formation of biofilm. Hence, the study provides a promising strategy for designing pro-osteogenesis and antibacterial coating on Ti substrates for orthopedic applications.

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BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement

Cited by 79 publications

References 36 publications

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Study of 1D Titanate‐Based Materials –New Modification of the Synthesis Procedure and Surface Properties‐Recent Applications

Zn‐incorporation with graphene oxide on Ti substrates surface to improve osteogenic activity and inhibit bacterial adhesion

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