2014
DOI: 10.3390/ijms150610150
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BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants

Abstract: The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local ost… Show more

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Cited by 45 publications
(30 citation statements)
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References 103 publications
(121 reference statements)
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“…In addition, FGF-2 enhanced the bone formation of only those animals with less-strong bone-forming ability in the FGF(+) group. FGF-2 is known to exhibit a bell-shaped dose response, where an excess of FGF-2 has less or no enhancement effect on bone formation [10, 14]. Animals having a sufficient level of endogenous FGF-2 in the FGF(+) group would not have responded to exogenous FGF-2.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, FGF-2 enhanced the bone formation of only those animals with less-strong bone-forming ability in the FGF(+) group. FGF-2 is known to exhibit a bell-shaped dose response, where an excess of FGF-2 has less or no enhancement effect on bone formation [10, 14]. Animals having a sufficient level of endogenous FGF-2 in the FGF(+) group would not have responded to exogenous FGF-2.…”
Section: Discussionmentioning
confidence: 99%
“…However, 5 rhBMP-2 presents outstanding regenerative properties and thus there is an unmet need for a 6 biocompatible, fully resorbable delivery system for the controlled, targeted release of this vivo, these materials demonstrated increased levels of healing of critical-sized rat calvarial 18 defects 8 weeks post-implantation compared to an empty defect and unloaded CHA scaffold, 19 without eliciting bone anomalies or adjacent bone resorption. These results demonstrate that it 20 is possible to achieve bone regeneration using 30 times less rhBMP-2 than INFUSE®, the 21 current clinical gold standard; thus, this work represents the first step of the development of a 14 RhBMP-2 is a primary growth factor (GF) for bone tissue regeneration, and it is involved in and osteoinductive [13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…In order to facilitate delivery of rhBMP-2 from these CHA scaffolds, we aimed to see if it was 13 possible to adopt a carrier-free approach, without the utilization of pre-or post-fabrication 14 scaffold functionalization processes previously adopted [17][18][19]. As such, we evaluated the Initially, this study explored whether it was possible to directly incorporate rhBMP-2 into the 24 scaffold using the proposed lyophilization method and subsequently how the incorporation of the GF into CHA scaffolds affected their architecture, the release profile of the GF from 1 scaffolds as well as the bioactivity of the protein were studied.…”
mentioning
confidence: 99%
“…It has been reported that rhBMP2 can be successfully coated to materials by multilayered inorganic microparticles and as layer‐by‐layer coatings and can be used to improve bone regeneration. However, the preparation process of rhBMP2 is complicated with a long production cycle and a very short half‐life . Accordingly, the diffusion of BMP2 can result in adverse events such as native bone resorption, unwanted ectopic bone formation, soft tissue swelling, and osteolysis .…”
Section: Introductionmentioning
confidence: 99%
“…However, the preparation process of rhBMP2 is complicated with a long production cycle and a very short half-life. 11,12 Accordingly, the diffusion of BMP2 can result in adverse events such as native bone resorption, unwanted ectopic bone formation, soft tissue swelling, and osteolysis. 13 Therefore, researchers are dedicated to extracting functional fragments of BMP2, namely, BMP2 peptides, which have attracted increasing attention in the field of bone regeneration.…”
Section: Introductionmentioning
confidence: 99%