Abstract:BackgroundLoosening of screws is a common problem in orthopedic and maxillofacial surgery. Modifying the implant surface to improve the mechanical strength of screws has been tried and reported. We developed screws coated with fibroblast growth factor-2 (FGF-2)−apatite composite layers. We then showed, in a percutaneous external fixation model, that this composite layer had the ability to hold and release FGF-2 slowly, thereby reducing the risk of pin tract infection of the percutaneous external fixation. The … Show more
“…Their analysis for 5-year overall survival included eight studies and concluded that patients receiving LSS had significantly better results than those receiving amputation [28] . On the other hand, the meta-analysis from He et al that included ten studies supported that patients managed either with LSS or amputation had similar 5-year survival [11] . Excluding three studies that caused heterogeneity and whose subjects were Asians; however, they found that the 5-year overall survival rate was higher in patients treated with LSS than those treated with amputation [11] .…”
Section: Discussionmentioning
confidence: 97%
“…There are two main surgical techniques: limb salvage surgery (LSS) and amputation [11] . Limb salvage techniques aim to widely excise of the tumor at the margins of healthy tissue.…”
Highlights
Osteosarcoma is the most common primary bone sarcoma.
Neoadjuvant chemotherapy combined with limb salvage surgery (LSS) or amputation are the main strategies in treating limb osteosarcoma.
LSS is associated with a higher 5-year overall survival.
Local recurrence was more frequently encountered in patients treated with LSS, however not affecting overall survival.
“…Their analysis for 5-year overall survival included eight studies and concluded that patients receiving LSS had significantly better results than those receiving amputation [28] . On the other hand, the meta-analysis from He et al that included ten studies supported that patients managed either with LSS or amputation had similar 5-year survival [11] . Excluding three studies that caused heterogeneity and whose subjects were Asians; however, they found that the 5-year overall survival rate was higher in patients treated with LSS than those treated with amputation [11] .…”
Section: Discussionmentioning
confidence: 97%
“…There are two main surgical techniques: limb salvage surgery (LSS) and amputation [11] . Limb salvage techniques aim to widely excise of the tumor at the margins of healthy tissue.…”
Highlights
Osteosarcoma is the most common primary bone sarcoma.
Neoadjuvant chemotherapy combined with limb salvage surgery (LSS) or amputation are the main strategies in treating limb osteosarcoma.
LSS is associated with a higher 5-year overall survival.
Local recurrence was more frequently encountered in patients treated with LSS, however not affecting overall survival.
“…It is hypothesized that the fundamental reason for the use of this smaller amount of injected SVFs in clinical application is likely the inability of investigators to isolate large number of cells from adipose tissue collected from their patients. Most of the stem cell studies also used this general number range of stem cells, likely due to high costs and cumbersome technique necessary to provide large number of stem cells [ 34 ]. One exception was particular autologous human adipose-derived MSCs (ADMSCs) study by Ra et al in spinal cord injury (SCI) patients [ 35 ].…”
Background. Stromal vascular fraction (SVF) therapy has been performed over the past six years to treat 421 patients by our group in five clinical centers. Autologous SVF, which is a substance containing stem cells, was isolated from lipoaspirate, mixed with platelet-rich plasma (PRP), and administered to patients with degenerative diseases, autoimmune diseases, trauma, aging, and other diseases with unknown etiology. This study aimed to determine the safety of SVF and PRP that were given through infusion, spinal, and intra-articular injection. Methods. The lipoaspirate was treated with a tissue-dissociating enzyme, and then, through centrifugation, SVF was isolated. In addition, blood was drawn from each patient, and PRP was isolated. Autologous PRP and SVF were administered to all subjects by intravenous (IV) injection. A minority group within the population received an additional spinal or intra-articular injection. The type of intervention was determined by each disease evaluation. The cell doses and adverse events for each patient were documented and analyzed. Results. Cell dose that was considered to be safe was less than 10 billion SVF cells in 250 cc of normal saline, for IV injection, and less than 1 billion SVF, for intra-articular and spinal injection. Adverse events were not severe and were treated successfully. Any observed adverse events were identified as a result of spinal or intra-articular injections and were not related to SVF or PRP. Conclusions. Our results showed that administration of high dose of SVF until 10 billion cells in a majority of 421 patients through infusion, spinal, and intra-articular injection was feasible without causing major adverse events and should be further investigated in well-designed phase I-II clinical trial to address the safety and efficacy of therapy.
“…To our knowledge, this is the first whole knee joint FE modelling study, where the subject number is this large. In most of the previous knee joint finite element studies, the subject number was restricted to one or two 47 – 49 . On the other hand, since our inclusion criteria were tight, there were only 7 suitable subjects for KL3 group in OAI database.…”
Economic costs of osteoarthritis (OA) are considerable. However, there are no clinical tools to predict the progression of OA or guide patients to a correct treatment for preventing OA. We tested the ability of our cartilage degeneration algorithm to predict the subject-specific development of OA and separate groups with different OA levels. The algorithm was able to predict OA progression similarly with the experimental follow-up data and separate subjects with radiographical OA (Kellgren-Lawrence (KL) grade 2 and 3) from healthy subjects (KL0). Maximum degeneration and degenerated volumes within cartilage were significantly higher (p < 0.05) in OA compared to healthy subjects, KL3 group showing the highest degeneration values. Presented algorithm shows a great potential to predict subject-specific progression of knee OA and has a clinical potential by simulating the effect of interventions on the progression of OA, thus helping decision making in an attempt to delay or prevent further OA symptoms.
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