BMP-2 for intramuscular bone induction:Effect in squirrel monkeys is dependent on implantation site

Aspenberg, Per; Turek, Tom

doi:10.3109/17453679608995598

Cited by 74 publications

(34 citation statements)

References 17 publications

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“…There is no doubt that the implants contained active BMP-2: other implants from the same batch regularly induced marked bone formation intramuscularly in rats (Aspenberg and Turek 1996) as did most of the extraskeletal titanium implants in the rabbits. The inhibitory effect on bone healing in the chambers was obvious.…”

Section: Discussionmentioning

confidence: 99%

“…Recombinant human BMP-2, formulated in a cryoprotectant buffer system had been lyophilized onto the discs, so that they contained 0 (control), 10 and 200 pg per disc. Discs from the same batch regularly induced bone in a dose-dependent manner when intramuscularly implanted in rats (Aspenberg and Turek 1996). We cut the discs into pieces corresponding to a total dose of 0 pg, 0.6 pg, or 12 pg per piece.…”

Section: Animals and Bmp-2 Implantsmentioning

confidence: 99%

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BMP-2 can inhibit bone healing: Bone-chamber study in rabbits

Jeppsson

Aspenberg

1996

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

Section: Animals and Bmp-2 Implantsmentioning

confidence: 99%

BMP-2 can inhibit bone healing: Bone-chamber study in rabbits

Jeppsson

Aspenberg

1996

Acta Orthopaedica Scandinavica

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“…In addition, partially purified BMPs may be contaminated with several osteoinductive factors other than BMPs or with other unknown factors. rhBMPs are free of other growth factors and can be produced in unlimited quantity, and species-specificity of BMP-2 is thought to present less of a problem in clinical use [2,5,9,22,25,28]. Heckman and Boyan [7] reported that canine BMPs combined with bovine DBM carrier were also ineffective, suggesting that purity of the carrier is also an important factor for osteoinduction.…”

Section: Discussionmentioning

confidence: 99%

Repair of Ulnar Segmental Defect by Recombinant Human Bone Morphogenetic Protein-2 in Dogs.

Itoh

Mochizuki

Nishimura

et al. 1998

The Journal of Veterinary Medical Science

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ABSTRACT. The efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with poly D, L lactic-co-glycolic acid (PLGA)/gelatin sponge complex (PGS) as a carrier on the repair of segmental long-bone defects was evaluated using an ulnar model in dogs. The defect was 2 cm in length and was fixed with bone plating. After implantation of PGS with or without rhBMP-2, the repair process of the defect was evaluated by serial radiography until 16 postoperative weeks. All defects treated with 160 µg or 640 µg of rhBMP-2/PGS revealed bone union radiographically by 12 postoperative weeks, whereas all defects treated with PGS alone revealed no radiographic evidence of healing throughout the experimental period. In defects treated with 40 µg of rhBMP-2/PGS, new bone appeared partially at the defects but did not accomplish union. Bone mineral contents at the defect sites after harvest at 16 weeks postoperatively were significantly (p<0.05) higher in those treated with 160 µg or 640 µg of rhBMP-2 than in those treated with 40 µg of rhBMP-2 or PGS alone. Histologically, defects radiographically diagnosed as having achieved union showed the appearance of cortical bone and bone marrow cells. These findings suggest the use of rhBMP-2/PGS as a potential bone graft substitute in reconstructive surgery in dogs. -KEY WORDS: canine, rhBMP-2, ulnar defect.

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“…In squirrel monkeys, the effect of BMP-2 in extraskeletal sites is weak, but clearly dependent on the implantation site (Aspenberg 1996). Another uncertainity is, of course, the glucocorticoid treatment.…”

Section: Discussionmentioning

confidence: 99%