Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer

Lin, Wumei; Li, Zhigang

doi:10.3892/ol.2017.6094

Cited by 21 publications

(9 citation statements)

References 33 publications

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“…Anthocyanin and anthocyanidin extracts from blueberry can inhibit the proliferation and trigger the apoptosis of B16-F10 cells [ 33 ]. Blueberry consumption (400 mg daily) can reduce tumor size significantly in mice, which inhibited the proliferation of ovarian cancer cells by downregulating the levels of cyclooxygenase-1 and cyclooxygenase-2 [ 34 ].…”

Section: Preventive Chronic Disease Of Blueberrymentioning

confidence: 99%

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Sun

Zeng

et al. 2018

IJMS

120

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Functional ingredients in blueberry have the best health benefits. To obtain a better understanding of the health role of blueberry in chronic disease, we conducted systematic preventive strategies for functional ingredients in blueberry, based on comprehensive databases, especially PubMed, ISI Web of Science, and CNKI for the period 2008–2018. Blueberry is rich in flavonoids (mainly anthocyanidins), polyphenols (procyanidin), phenolic acids, pyruvic acid, chlorogenic acid, and others, which have anticancer, anti-obesity, prevent degenerative diseases, anti-inflammation, protective properties for vision and liver, prevent heart diseases, antidiabetes, improve brain function, protective lung properties, strong bones, enhance immunity, prevent cardiovascular diseases, and improve cognitive decline. The anthocyanins and polyphenols in blueberry are major functional ingredients for preventive chronic disease. These results support findings that blueberry may be one of the best functional fruits, and further reveals the mechanisms of anthocyanins and polyphenols in the health role of blueberry for chronic disease. This paper may be used as scientific evidence for developing functional foods, nutraceuticals, and novel drugs of blueberry for preventive chronic diseases.

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Section: Preventive Chronic Disease Of Blueberrymentioning

confidence: 99%

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Sun

Zeng

et al. 2018

IJMS

120

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“…Therefore, the identification of multitarget agents with high effectiveness is required. 37,41 Several reports have shown that either COX-1 or COX-2 is upregulated in EOC. Treatment with COX-1-and COX-2-specific inhibitors may exhibit a therapeutic effect on EOC.…”

Section: Targeting Coxs In the Treatment Of Eocmentioning

confidence: 99%

“…23,36,42,43 Table 1 summarizes the major treatment strategies of EOC and the consequences by targeting COXs. Lin and Li 41 reported that blueberries may affect the progression of EOC by downregulating the levels of COX-1 and COX-2. Eilati et al 44 suggested that targeting PG biosynthesis might also be an effective approach in preventing EOC.…”

Section: Targeting Coxs In the Treatment Of Eocmentioning

confidence: 99%

Cyclooxygenase Inhibitors in Epithelial Ovarian Cancer Treatment

Zeng

Yi²

2018

International Journal of Gynecological Cancer

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Epithelial ovarian cancer (EOC) is the fifth most common cause of cancer mortality among women. At present, EOC is treated with one or in a combination of treatments, commonly debulking surgery, combining a platinum-based and a taxane-based therapy; however, the patients have a risk of injury to the bowel, bladder, ureter, and vessels during surgery and many of them suffer from severe adverse effects caused by chemotherapy. Pharmaceutical inhibition of cyclooxygenase (COX) might be an important therapeutic tool in cancer treatment, as COX contributes to cancer progression by upregulating the levels of downstream metabolites. In this review article, we have discussed the role of COX in cancer progression and the therapeutic use of COX inhibitors in the treatment of EOC with subsequent clinical studies and future management. Usually, gonadotropins can promote prostaglandin E2 production in EOC cells via COX-1 and -2 upregulations through the PI3K/AKT signaling pathway. Several reports have shown that treatment of EOC cells with COX-1- and COX-2-specific inhibitors exhibits a therapeutic effect on EOC both in vitro and in vivo. However, more clinical investigations are needed to develop therapeutic COX inhibitors for the prevention and treatment of EOC without adverse effects.

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“…The reactions they catalyze rely on the use of arachidonic acid (AA) as a substrate, obtained through the activity of cytoplasmic phospholipase A2 (cPLA2) from cell membrane phospholipids [15]. Both cyclooxygenase isoforms catalyze the transformation of AA into prostaglandin H2 (PGH2), from which the remaining prostaglandins and thromboxanes are synthesized [16][17][18]. The COX-1 gene expression in most cells is constitutive [19].…”

Section: Introductionmentioning

confidence: 99%

Lead (Pb) as a Factor Initiating and Potentiating Inflammation in Human THP-1 Macrophages

Metryka

Kupnicka

Kapczuk

et al. 2020

IJMS

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The aim of this study was to assess the influence of lead (Pb) at low concentrations (imitating Pb levels in human blood in chronic environmental exposure to this metal) on interleukin 1β (IL-1β) and interleukin 6 (IL-6) concentrations and the activity and expression of COX-1 and COX-2 in THP-1 macrophages. Macrophages were cultured in vitro in the presence of Pb at concentrations of: 1.25 μg/dL; 2.5 μg/dL; 5 μg/dL; 10 μg/dL. The first two concentrations of Pb were selected on the basis of our earlier study, which showed that Pb concentration in whole blood (PbB) of young women living in the northern regions of Poland and in the cord blood of their newborn children was within this range (a dose imitating environmental exposure). Concentrations of 5 μg/dL and 10 μg/dL correspond to the previously permissible PbB concentrations in children or pregnant women, and adults. Our results indicate that even low concentrations of Pb cause an increase in production of inflammatory interleukins (IL-1β and IL-6), increases expression of COX-1 and COX-2, and increases thromboxane B2 and prostaglandin E2 concentration in macrophages. This clearly suggests that the development of inflammation is associated not only with COX-2 but also with COX-1, which, until recently, had only been attributed constitutive expression. It can be concluded that environmental Pb concentrations are able to activate the monocytes/macrophages similarly to the manner observed during inflammation.

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Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer

Cited by 21 publications

References 33 publications

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Cyclooxygenase Inhibitors in Epithelial Ovarian Cancer Treatment

Lead (Pb) as a Factor Initiating and Potentiating Inflammation in Human THP-1 Macrophages

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