Blue light (λ=453 nm) nitric oxide dependently induces β-endorphin production of human skin keratinocytes in-vitro and increases systemic β-endorphin levels in humans in-vivo

Albers, Isabel; Zernickel, Erika; Stern, M. E.; Broja, Melanie; Busch, Lucas; Heiß, Christian; Grotheer, Vera; Windolf, Joachim; Suschek, Christoph V.

doi:10.1016/j.freeradbiomed.2019.09.022

Cited by 17 publications

(10 citation statements)

References 49 publications

(76 reference statements)

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“…While glutamate acts as a neuromediator, artemin has a neuroprotective role, as well as a role in sensation perception [ 139 ]. β-endorphin has a local effect for pain management [ 140 ]. α-MSH serves locally to stimulate melanocytes for pigment production and regulate inflammation and extracellular matrix homeostasis through the receptor MC1R [ 141 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

El‐Serafi

El-Serafi

Steinvall

et al. 2022

IJMS

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Cell regenerative therapy is a modern solution for difficult-to-heal wounds. Keratinocytes, the most common cell type in the skin, are difficult to obtain without the creation of another wound. Stem cell differentiation towards keratinocytes is a challenging process, and it is difficult to reproduce in chemically defined media. Nevertheless, a co-culture of keratinocytes with stem cells usually achieves efficient differentiation. This systematic review aims to identify the secretions of normal human keratinocytes reported in the literature and correlate them with the differentiation process. An online search revealed 338 references, of which 100 met the selection criteria. A total of 80 different keratinocyte secretions were reported, which can be grouped mainly into cytokines, growth factors, and antimicrobial peptides. The growth-factor group mostly affects stem cell differentiation into keratinocytes, especially epidermal growth factor and members of the transforming growth factor family. Nevertheless, the reported secretions reflected the nature of the involved studies, as most of them focused on keratinocyte interaction with inflammation. This review highlights the secretory function of keratinocytes, as well as the need for intense investigation to characterize these secretions and evaluate their regenerative capacities.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

El‐Serafi

El-Serafi

Steinvall

et al. 2022

IJMS

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“…NO is released as part of thermoregulation, an adaptive process that tightly regulates body heat to prevent heat stress, which can be fatal [76]. Sunlight and arti cial light also increase systemic NO levels [66,[77][78][79][80][81][82][83] while decreasing blood pressure and vascular resistance [66,68,[77][78][79][80][81][82][83]. Because high NO and NO-metabolite levels are found in people with histories of suicide attempts [84][85][86], heat and/or light-induced NO increases could increase risk for suicide.…”

Section: Discussionmentioning

confidence: 99%

Temporal patterns of suicide and circulatory system disease-related mortality are inversely correlated in several countries

Kaufman

Fitzmaurice

2020

Preprint

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Background Nearly 800,000 suicides occur worldwide annually and suicide rates are increasing faster than population growth. Unfortunately, the pathophysiology of suicide remains poorly understood, which has hindered suicide prevention efforts. However, mechanistic clues may be found by studying effects of seasonality on suicide and other mortality causes. Suicides tend to peak in spring-summer periods and nadir in fall-winter periods while circulatory system disease-related mortality tends to exhibit the opposite temporal trends. This study aimed to determine for the first time whether monthly temporal cross-correlations exist between suicide and circulatory system disease-related mortality at the population level. If so and if common biological factors moderate risks for both mortality types, such factors may be discoverable and utilized to improve suicide prevention.Methods We conducted time series analyses of monthly mortality data from northern (England and Wales, South Korea, United States) and southern (Australia, Brazil) hemisphere countries during the period 2009-2018 (N=41.8 million all-cause mortality cases). We used a Poisson regression variant of the standard cosinor model to determine cross-correlations between monthly mortality rates from suicide and from circulatory system diseases.Results Suicide and circulatory disease-related mortality temporal patterns were negatively correlated in Australia (-0.32), Brazil (-0.57), South Korea (-0.32), and in the United States (-0.66), but no temporal correlation was discernable in England and Wales.Conclusions The negative temporal cross-correlations between these mortality types we found in 4 of 5 countries studied suggest that seasonal factors broadly and inversely moderate risks for circulatory disease-related mortality and suicide. Since the seasonal factors of temperature and light exert opposite effects on suicide and circulatory disease-related mortality in several countries, we propose that physiologically-adaptive circulatory system responses to heat and light may increase risk for suicide and should be studied to determine whether they affect suicide risk. For example, heat and light increase production and release of the bioactive gas nitric oxide and reduce circulatory system disease by relaxing blood vessel tone, while elevated nitric oxide levels are associated with suicidal behavior, inverse effects that parallel the inverse temporal mortality patterns we detected.

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“…Although plasma levels of β‐END in humans do not increase after UVR exposure, 260‐262 skin biopsies of healthy volunteers showed increased epidermal β‐END 24 hours after exposure to NB‐UVB 263 . Interestingly, blue light irradiation ( γ = 453 nm) significantly enhanced both keratinocyte culture β‐END production and systemic β‐END concentrations, along with bioactive NO‐derivatives, in healthy individuals 264 . The topic is further complicated by the observation that administration of an opioid antagonist, naltrexone, to a small group of frequent users of tanning beds induced opioid withdrawal‐like symptoms of jitteriness, nausea and shaking 265 .…”

Section: Proopiomelanocortin (Pomc) Alpha‐melanocyte Stimulating Hormone (α‐Msh) Beta‐endorphin (β‐End) and Adrenocorticotropic Hormone (mentioning

confidence: 96%

“…263 Interestingly, blue light irradiation (γ = 453 nm) significantly enhanced both keratinocyte culture β-END production and systemic β-END concentrations, along with bioactive NO-derivatives, in healthy individuals. 264 The topic is further complicated by the observation that administration of an opioid antagonist, naltrexone, to a small group of frequent users of tanning beds induced opioid withdrawal-like symptoms of jitteriness, nausea and shaking. 265 A mouse study showed systemic β-END elevation after chronic UVR exposure that was accompanied by increased mechanical and thermal nociceptive thresholds, F I G U R E 3 Summary of local and systemic sources of POMC and its derivates, and their respective immune, inflammatory and cell biologic effects.…”

Section: Endorphin (β-End) and Adrenocorticotropic Hormone (Acth)mentioning

confidence: 99%

Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

Moattari

Granstein

2021

Acta Physiologica

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Humans are exposed to varying amounts of ultraviolet radiation (UVR) through sunlight. UVR penetrates into human skin leading to release of neuropeptides, neurotransmitters and neuroendocrine hormones. These messengers released from local sensory nerves, keratinocytes, Langerhans cells (LCs), mast cells, melanocytes and endothelial cells (ECs) modulate local and systemic immune responses, mediate inflammation and promote differing cell biologic effects. In this review, we will focus on both animal and human studies that elucidate the roles of calcitonin gene-related peptide (CGRP), substance P (SP), nerve growth factor (NGF), nitric oxide and proopiomelanocortin (POMC) derivatives in mediating immune and inflammatory effects of exposure to UVR as well as other cell biologic effects of UVR exposure.

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Blue light (λ=453 nm) nitric oxide dependently induces β-endorphin production of human skin keratinocytes in-vitro and increases systemic β-endorphin levels in humans in-vivo

Cited by 17 publications

References 49 publications

A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

Temporal patterns of suicide and circulatory system disease-related mortality are inversely correlated in several countries

Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

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Blue light (λ=453 nm) nitric oxide dependently induces β-endorphin production of human skin keratinocytes in-vitro and increases systemic β-endorphin levels in humans in-vivo

Cited by 17 publications

References 49 publications

A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

Temporal patterns of suicide and circulatory system disease-related mortality are inversely correlated in several countries

Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

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Product

Resources

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Blue light (λ=453 nm) nitric oxide dependently induces β-endorphin production of human skin keratinocytes in-vitro and increases systemic β-endorphin levels in humans in-vivo