Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

Moattari, Cameron R.; Granstein, Richard D.

doi:10.1111/apha.13644

Cited by 10 publications

(9 citation statements)

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“…In our laboratory, the bystander signal mostly involved UVA photon emissions wherever LDIR interacted with cells. There is extensive literature that UV interacts with the immune system, particularly Langerhans cells (Ullrich and Byrne 2012;Moattari and Granstein 2021). While this is outside the scope of this paper, it is interesting to consider that UVA biophotons generated due to ionizing radiation interaction in deep tissues could be a mechanism leading to an ionizing radiation-induced immune response.…”

Section: Mechanisms Of Immune Modulation Via Radiation Induced Non-targeted Effects (Nte)mentioning

confidence: 98%

Low dose ionizing radiation and the immune response: what is the role of non-targeted effects?

Dawood

Mothersill

Seymour

2021

International Journal of Radiation Biology

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Objectives: This review aims to trace the historical narrative surrounding the low dose effects of radiation on the immune system and how our understanding has changed from the beginning of the 20th century to now. The particular focus is on the non-targeted effects (NTEs) of low dose ionizing radiation (LDIR) which are effects that occur when irradiated cells emit signals that cause effects in the nearby or distant non-irradiated cells known as radiation induced bystander effect (RIBE). Moreover, radiation induced genomic instability (RIGI) and abscopal effect (AE) also regarded as NTE. This was prompted by our recent discovery that ultraviolet A (UVA) photons are emitted by the irradiated cells and that these photons can trigger NTE such as the RIBE in unirradiated recipients of these photons. Given the well-known association between UV radiation and the immune response, where these biophotons may pose as bystander signals potentiating processes in deep tissues as a consequence of LDIR, it is timely to review the field with a fresh lens. Various pathways and immune components that contribute to the beneficial and adverse types of modulation induced by LDR will also be revisited. Conclusion:There is limited evidence for LDIR induced immune effects by way of a non-targeted mechanism in biological tissue. The literature examining low to medium dose effects of ionizing radiation on the immune system and its components is complex and controversial. Early work was compromised by lack of good dosimetry while later work mainly looks at the involvement of immune response in radiotherapy. There is a lack of research in the LDIR/NTE field focusing on immune response although bone marrow stem cells and lineages were critical in the identification and characterization of NTE where effects like RIGI and RIBE were heavily researched. This may be in part, a result of the difficulty of isolating NTE in whole organisms which are essential for good immune response studies. Models involving inter organism transmission of NTE are a promising route to overcome these issues.

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Section: Mechanisms Of Immune Modulation Via Radiation Induced Non-targeted Effects (Nte)mentioning

confidence: 98%

Low dose ionizing radiation and the immune response: what is the role of non-targeted effects?

Dawood

Mothersill

Seymour

2021

International Journal of Radiation Biology

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“…Additionally, the SP-induced Ca2+ influx affects the degranulation mechanism of MCs. Furthermore, SP induces histamine release from MCs ( 71 , 72 ) ( Figure 2A ). McCary reported that SP can downregulate the expression of the high-affinity IgE receptor (FcεRI) mRNA and protein on the surface of human MCs, which in turn limits MC activation ( 73 ).…”

Section: Role Of Neuropeptides In Neuroimmune Communication In Armentioning

confidence: 99%

Neuroimmune communication in allergic rhinitis

Zhou,

Chen,

Kong

et al. 2023

Front. Neurol.

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The prevalence rate of allergic rhinitis (AR) is high worldwide. The inhalation of allergens induces AR, which is an immunoglobulin E-mediated and type 2 inflammation-driven disease. Recently, the role of neuroimmune communication in AR pathogenesis has piqued the interest of the scientific community. Various neuropeptides, such as substance P (SP), vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP), nerve growth factor (NGF), and neuromedin U (NMU), released via “axon reflexes” or “central sensitization” exert regulatory effects on immune cells to elicit “neurogenic inflammation,” which contributes to nasal hyperresponsiveness (NHR) in AR. Additionally, neuropeptides can be produced in immune cells. The frequent colocalization of immune and neuronal cells at certain anatomical regions promotes the establishment of neuroimmune cell units, such as nerve-mast cells, nerve-type 2 innate lymphoid cells (ILC2s), nerve-eosinophils and nerve-basophils units. Receptors expressed both on immune cells and neurons, such as TRPV1, TRPA1, and Mas-related G protein-coupled receptor X2 (MRGPRX2) mediate AR pathogenesis. This review focused on elucidating the mechanisms underlying neuroimmune communication in AR.

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“…consequences. Dopamine detox protocols found online usually encompass a selection of any or all of the following abstinences: foods high in sugar, fat and glutamate, impulse buying, unscheduled media consumption, and other, similar behaviors or other substances, some of them with direct detrimental health effects (nicotine 6 or UV tanning 7 ), but all of them blamed for creating short-lived feelings of pleasure, followed by cravings or even withdrawal symptoms. Systematic, peer-reviewed data are, to the best of our knowledge, lacking, while sporadic evidence is out there, so it may be worth taking a look at what's new in physiological monoamine research.…”

Section: Did You Know? Dopamine Pop Culture and Beyondmentioning

confidence: 99%

Did you know? Dopamine, pop culture and beyond

Persson

2023

Acta Physiologica

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Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

Cited by 10 publications

References 271 publications

Low dose ionizing radiation and the immune response: what is the role of non-targeted effects?

Low dose ionizing radiation and the immune response: what is the role of non-targeted effects?

Neuroimmune communication in allergic rhinitis

Did you know? Dopamine, pop culture and beyond

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