Blood Volume and its Regulation

Em, Brown; Hopper, J.; Wennesland, Reidar

doi:10.1146/annurev.ph.19.030157.001311

Cited by 41 publications

(10 citation statements)

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“…The positive correlation found between residuals for Vrbc and Vpl (r = + 0.42) means that a man whose Vrbc is larger than average for his height and weight will also tend to have a large Vpl. This is in contrast to the inverse relation between Vrbc and Vpl found in certain pathologic states, e.g., anemia and polycythemia (38), and suggests that the normal biologic determinants of blood volume may be concerned with circulatory volume rather than with total circulating hemoglobin.…”

Section: Dicussionmentioning

confidence: 61%

RED CELL, PLASMA AND BLOOD VOLUME IN HEALTHY MEN MEASURED BY RADIOCHROMIUM (Cr51) CELL TAGGING AND HEMATOCRIT: INFLUENCE OF AGE, SOMATOTYPE AND HABITS OF PHYSICAL ACTIVITY ON THE VARIANCE AFTER REGRESSION OF VOLUMES TO HEIGHT AND WEIGHT COMBINED*

Wennesland¹,

Em²,

Hopper³

et al. 1959

J. Clin. Invest.

193

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Section: Dicussionmentioning

confidence: 61%

RED CELL, PLASMA AND BLOOD VOLUME IN HEALTHY MEN MEASURED BY RADIOCHROMIUM (Cr51) CELL TAGGING AND HEMATOCRIT: INFLUENCE OF AGE, SOMATOTYPE AND HABITS OF PHYSICAL ACTIVITY ON THE VARIANCE AFTER REGRESSION OF VOLUMES TO HEIGHT AND WEIGHT COMBINED*

Wennesland¹,

Em²,

Hopper³

et al. 1959

J. Clin. Invest.

193

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“…The hematocrits would therefore be expected to be lower than those of samples taken from ambulatory subjects under ordinary conditions of collection (4,8). The positive correlation between residuals of Vrbc and Vpl for women and men (1) shows that the he- ficiency or excess of cell mass is often balanced by reciprocal expansion or contraction of plasma (9). In this study, the coefficient of variation (SD as per cent of the mean) was 5.1 per cent for hematocrit and 8.6 per cent for Vwb after regression to weight and height (Table II).…”

Section: Analysis Of Residualsmentioning

confidence: 99%

Red Cell, Plasma, and Blood Volume in Healthy Women Measured by Radiochromium Cell-Labeling and Hematocrit*

Em¹,

Hopper²,

Hodges³

et al. 1962

J. Clin. Invest.

190

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In a previous study of 201 healthy men (1), red cell volume (Vrbc) was measured by a modification of Sterling and Gray's radiochromium method (2), and whole blood and plasma volumes (Vwb and Vpl) were derived from venous hemiatocrits. The influence of factors other than body size on the variance of the data was studied, and standards for predicting normal volumes were derived. The present report describes a similar examination of 101 women. SUBJECTS AND METHODSThe women, all of whom volunteered for study, were actively employed as housewives, laboratory personnel, nurses, or office workers, and most were white (Table I) tResearch Fellow, American Heart Association. prevent venous congestion during sampling. Hematocrit readings were not corrected for plasma trapping, and it was assumed that Vwb = VCr"1 (no allowance was made for a difference between the hematocrit of venous blood and that of the body as a whole) (1). Cell and plasma volumes were calculated by the formulas: Vrhc = VCr`1 X hematocrit; Vpl = VCr5`-Vrbc.The data were treated as outlined in the study of men (1). Regression equations were calculated by the method of least squares to describe the relations between volumes (Vrbc, Vpl, and Vwb) and body measurements (weight, height, weight and height combined, and surface area). The differences between the observed volumes (Vrbc and Vpl) of each woman and the mean volumes found in women of the same height and weight vere calculated by means of Equations 3 and 7, Table II. These differences, or "residuals," wsere used to analyze the influence of factors other than body size On the blood volumes. Table I summarizes the data. In Figure 1, each of the 101 subjects is represented according to her weight and height. In general, the relationship between weight and height was fairly uniform. Notable exceptions were four women weighing over 81 kg, who proved to be 23 to 58 per cent overweight for height and age according to actuarial tables (5). The weight: height ratios of these subjects were more than 2 standard deviations above the mean of the ratios of the other 97 women. For this reason and because the series included so few large women, regression equations describing the relationships of the volumes to body measurements were prepared only for the 97 women weighing less than 74 kg (Table II). RESULTS Volumes in relation to height and weightThe bivariate regression equations described straight lines and the trivariate equations, planes without curvature (see Figures 1 to 4). The location of the regression plane for Vrbc in rela-2182

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“…Methods of estimating circulating red cell and plasma volume have been reviewed in terms of their technical details, their accuracy in normal individuals, and the changes measured in disease (Reeve, 1948;von Porat, 1951 ;Gregersen, 1951;Mollison, 1956;Wiklander, 1956;Brown, Hopper, and Wennesland, 1957). Much less evidence is available on the inaccuracies that may be found when disease is present.…”

mentioning

confidence: 99%

A Critical Evaluation of Red Cell and Plasma Volume Techniques in Patients With Civilian Injuries

Davies¹,

Topley²

1959

J Clin Pathol

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Blood Volume and its Regulation

Cited by 41 publications

References 0 publications

RED CELL, PLASMA AND BLOOD VOLUME IN HEALTHY MEN MEASURED BY RADIOCHROMIUM (Cr51) CELL TAGGING AND HEMATOCRIT: INFLUENCE OF AGE, SOMATOTYPE AND HABITS OF PHYSICAL ACTIVITY ON THE VARIANCE AFTER REGRESSION OF VOLUMES TO HEIGHT AND WEIGHT COMBINED*

RED CELL, PLASMA AND BLOOD VOLUME IN HEALTHY MEN MEASURED BY RADIOCHROMIUM (Cr51) CELL TAGGING AND HEMATOCRIT: INFLUENCE OF AGE, SOMATOTYPE AND HABITS OF PHYSICAL ACTIVITY ON THE VARIANCE AFTER REGRESSION OF VOLUMES TO HEIGHT AND WEIGHT COMBINED*

Red Cell, Plasma, and Blood Volume in Healthy Women Measured by Radiochromium Cell-Labeling and Hematocrit*

A Critical Evaluation of Red Cell and Plasma Volume Techniques in Patients With Civilian Injuries

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