A Critical Evaluation of Red Cell and Plasma Volume Techniques in Patients With Civilian Injuries

Davies, J.W.L.; Topley, Elizabeth

doi:10.1136/jcp.12.4.289

Cited by 23 publications

(12 citation statements)

References 24 publications

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“…Mott (1965) foundthat bloodvolumes calculated from haemoglobin measurements averaged 5 % less than those made in the same rabbits using red cells labelled with 51Cr. Davies & Topley (1959) found that simultaneous determinations of red cell volume using 32p and 51Cr labelled cells agreed within + 5 %. However, they observed significantly more instances of leakage of label sufficient to raise the supernatant activity above 1 % of the total' when 32p was used.…”

Section: Discussionmentioning

confidence: 96%

The relation of blood volume to body weight and arterial haemoglobin levels in rabbits

Mott¹

1967

The Journal of Physiology

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SUMMARY1. Relative blood volume (ml./kg) of rabbits calculated from total circulating haemoglobin and blood haemoglobin concentration decreases rapidly during the first few weeks of life and more slowly thereafter.2. In anaemic rabbits over 1 kg body weight, relative blood volume is significantly increased.3. Rabbits under 1 kg body weight have larger blood volumes than would be expected from their anaemia alone, were the relationship deduced in rabbits over 1 kg in body weight applicable. Blood volume was not related to haemoglobin concentration in these immature rabbits.

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Section: Discussionmentioning

confidence: 96%

The relation of blood volume to body weight and arterial haemoglobin levels in rabbits

Mott¹

1967

The Journal of Physiology

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“…The technique based on that of Chaplin (1954) has already been described in detail (Davies and Topley, 1959).…”

Section: Phosphorus [32p]mentioning

confidence: 99%

“…The following slight modifications of the technique described by Davies and Topley (1959) are based on the method of Mollison and Veall (1955). The dosage of radioactivity injected into the children did not exceed 0.5 ,uC/kg.…”

Section: Red Cells Labelled With Radioactivementioning

confidence: 99%

“…The published method (Davies and Topley, 1959) was used on five occasions in conjunction with the "Cr red cell volume method.…”

Section: Plasma Proteins Labelled With T-1824mentioning

confidence: 99%

“…An investigation was therefore carried out to show whether red cell volume estimations were likely to be accurate enough to improve the clinical management of patients with severe burns. The methods were similar to those previously described for patients with injuries other than burns (Davies and Topley, 1959).…”

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A Critical Evaluation of Red Cell and Plasma Volume Techniques in Patients With Burns

Davies

1960

J Clin Pathol

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From the results in 110 patients, in whom 207 red cell volume estimations were made at various times after burning using either rIC r-, 32p., or Group NN-labelled cells, and 17 plasma volume estimations on the same patients using either T-1 824-or 13 I-labelled albumin, it is concluded that:(a) The 5"Cr red cell volume method is the most reliable method; it gives results which are probably not in error by more than ± 10% when the labelled cells are washed three times and so has a place in the assessment of the changes in red cell volume that follow a severe bum. In conjunction with a well type scintillation counter the radiation dosage received by the patient with 53Cr is about one-fifth of that with any other method.(b) The 32p method is slightly less reliable, as shown by on average higher supernatant radioactivity levels and a greater scatter in the rate of disappearance of the isotope from the circulation.(c) The Ashby (Group NN) method and the plasma volume and haematocrit method are inaccurate in patients with burns.

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Clinical aspects of traumatic shock

Bull¹

1962

Shock Pathogenesis and Therapy

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A Critical Evaluation of Red Cell and Plasma Volume Techniques in Patients With Civilian Injuries

Cited by 23 publications

References 24 publications

The relation of blood volume to body weight and arterial haemoglobin levels in rabbits

The relation of blood volume to body weight and arterial haemoglobin levels in rabbits

A Critical Evaluation of Red Cell and Plasma Volume Techniques in Patients With Burns

Clinical aspects of traumatic shock

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