Blood Viscosity and Optimal Hematocrit in Preterm and Full-Term Neonates in 50– to 500–μm Tubes

Linderkamp, Otwin; Stadler, Achim A; Zilow, E P

doi:10.1203/00006450-199207000-00019

Cited by 43 publications

(38 citation statements)

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“…Among these factors, the concentration of blood cells contributes the most to determining blood viscosity. [3][4][5] A strong correlation has been demonstrated between blood viscosity and the concentration of blood cells. 5 Shear rate is an important factor regulating blood viscosity with non-Newtonian characteristics in the circulatory system.…”

Section: Introductionmentioning

confidence: 99%

Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Furukawa

Abumiya

Sakai

et al. 2016

Journal of Stroke and Cerebrovascular Diseases

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Section: Introductionmentioning

confidence: 99%

Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Furukawa

Abumiya

Sakai

et al. 2016

Journal of Stroke and Cerebrovascular Diseases

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“…Using adult blood, however, should not confuse the results, because the whole fetal blood viscosity is comparable to that of adults, despite the somewhat higher fetal hematocrit. This is so mainly because of the lower plasma viscosity in the fetus (13,14).…”

Section: Discussionmentioning

confidence: 99%

Chronic hypoxia increases fetoplacental vascular resistance in rat placenta perfused with blood

Kafka¹,

Vajnerová²,

Hampl³

2017

BLL

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BACKGROUND: Chronic hypoxia elevates vascular resistance on the fetal side of the placenta. However, when a low-viscosity perfusate is used, the increase in resistance caused by chronic hypoxia is relatively small (12 mmHg). In the present study, we tested the hypothesis that perfusion with more viscous fl uid (blood) will reveal more substantial effect of chronic hypoxia. METHODS: Using an isolated, dually perfused rat placenta perfused at a constant fl ow rate with homologous blood, perfusion pressure on the fetal side was measured. Then, the relationship between perfusion pressure and fl ow (P/Q) was determined. RESULTS: Fetoplacental vascular resistance was increased by chronic hypoxia (10 % O 2 ) during the last third of gestation. This was observed when the placentas were perfused with a low viscosity Krebs solution and more enhanced when perfused with blood. Nevertheless, we found no clear advantage for using blood instead of Krebs solution to study the effects of hypoxia on the fetoplacental vasculature. The elevation of fetoplacental vascular resistance caused by chronic hypoxia was at least partly resistant to acute reoxygenation. CONCLUSION: Using blood for the perfusion of the isolated rat placenta does not confer any clear methodological advantage over using Krebs solution (Tab. 2, Fig. 2, Ref. 21). Text in PDF www.elis.sk.

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“…Blood and plasma viscosities were determined by means of a capillary viscometer [20]. A tube with a diameter of 100 lm and length of 1 cm was perfused with whole blood and plasma at a temperature of 37°and a pressure of 25 cm H 2 0.…”

Section: Hemorheological Methodsmentioning

confidence: 99%

Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children

et al. 2005

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Deleterious microcirculatory effects of Intralipid (IL) infusion may be caused by hemorheological or vascular effects. The aim of this investigation was to study vascular and hemorheological effects of IL in preterm and fullterm neonates and children. Ten preterm newborns, 10 fullterm neonates, and 10 children received an initial infusion of IL (0.6 g/kg) over 4 h. Calf blood flow (venous occlusion plethysmography), blood pressure (Dinamap), whole blood and plasma viscosity (capillary viscometer), red blood cell deformability (rheoscope), and erythrocyte aggregation (aggregometer) were measured before and after administration of IL. Plasma triglyceride levels showed the greatest increase in preterm infants. Whole blood viscosity decreased by about 10% in all three groups because of a similar reduction in hematocrit. Red blood cell aggregation decreased by about 20% after IL infusion. Blood pressure rose by 10%, and peripheral blood flow declined by about 10% in the three groups. Vascular hindrance, a calculation of blood pressure divided by blood flow and viscosity, was raised by about 20%, suggesting marked vasoconstriction of peripheral arteries. Vasoconstriction rather than hemorheological changes during infusion of IL may play a crucial role in the pathogenesis of circulatory alterations in parenterallyfed neonates.

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Blood Viscosity and Optimal Hematocrit in Preterm and Full-Term Neonates in 50– to 500–μm Tubes

Cited by 43 publications

References 4 publications

Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Chronic hypoxia increases fetoplacental vascular resistance in rat placenta perfused with blood

Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children

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